Zobrazeno 1 - 10
of 96
pro vyhledávání: '"Peter A. Dormer"'
Autor:
Peter E. Maligres, Feng Peng, Ralph Calabria, Louis-Charles Campeau, Wenyong Chen, Peter G. Dormer, Meredith Green, Cyndi Qixin He, Alan M. Hyde, Artis Klapars, Mona Utne Larsen, John Limanto, Guiquan Liu, Yizhou Liu, Aaron Moment, Timothy Nowak, Rebecca T. Ruck, Michael Shevlin, Zhiguo Jake Song, Lushi Tan, Weidong Tong, Jacob H. Waldman, Honglin Ye, Ralph Zhao, George Zhou, Michael A. Zompa, Susan L. Zultanski
Publikováno v:
Organic Process Research & Development. 26:2728-2738
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4cc17f9a7ea6c08a6dbdfe3c97ba693e
https://doi.org/10.1021/acs.oprd.2c00191
https://doi.org/10.1021/acs.oprd.2c00191
Autor:
Peter G. Dormer, W. Peter Wuelfing, Mikhail Reibarkh, William P. Forrest, Roy Helmy, Paul L. Walsh, Nathan D. Rudd, R. Thomas Williamson
Publikováno v:
Molecular Pharmaceutics.
Novel treatment routes are emerging for an array of diseases and afflictions. Complex dosage forms, based on active pharmaceutical ingredients (APIs) with previously undesirable physicochemical characteristics, are becoming mainstream and actively pu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd781831ec8682b38df97d44b8a675db
https://doi.org/10.1021/acs.molpharmaceut.9b00958
https://doi.org/10.1021/acs.molpharmaceut.9b00958
Autor:
Matthew T. Tudge, Baoqiang Wan, Edward C. Sherer, Robert A. Reamer, Feng Peng, Zhiguo Jake Song, Lushi Tan, Peter G. Dormer, Amude M. Kassim, John Y. L. Chung, Cheng-yi Chen, Yonggang Chen, Mark G. McLaughlin
Publikováno v:
The Journal of Organic Chemistry. 82:9023-9029
A highly efficient asymmetric synthesis of the key tetrahydropyranol intermediate of DPP-4 inhibitor omarigliptin (1) is described. The successful development of a protecting-group- and precious-metal-free synthesis was achieved via the discovery of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eafa49b0870c374b17084bf7666208d7
https://doi.org/10.1021/acs.joc.7b01467
https://doi.org/10.1021/acs.joc.7b01467
Autor:
Rositza I. Petrova, Jeffrey C. Moore, Peter G. Dormer, Benjamin Marcune, Hallena R. Strotman, John Y. L. Chung
Publikováno v:
Organic Process Research & Development. 19:1418-1423
An asymmetric synthesis of orexin receptor antagonist MK-6096 piperidine core, ((3R,6R)-6-methylpiperidin-3-yl)methanol (3), is described. The target is synthesized in four steps and 40% overall yield from methyl vinyl ketone and diethyl malonate. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::28091e0dc8b143601827f66e66335c25
https://doi.org/10.1021/acs.oprd.5b00259
https://doi.org/10.1021/acs.oprd.5b00259
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 58:291-298
Compounds containing tritium are widely used across the drug discovery and development landscape. These materials are widely utilized because they can be efficiently synthesized and produced at high specific activity. Results from internally calibrat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb21ab586f1fb7ea7dcc0329f7e9ef5a
https://doi.org/10.1002/jlcr.3295
https://doi.org/10.1002/jlcr.3295
Publikováno v:
Angewandte Chemie (International ed. in English). 57(7)
Tritium-labeled molecules are critical tools for elucidating the binding and metabolic properties of bioactive compounds, particularly during pharmaceutical discovery. Direct tritiation of inert C-H bonds with T2 gas is an ideal approach for tritium
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::615179a2093ac7cc1d4acc54bfad96bd
https://pubmed.ncbi.nlm.nih.gov/29314462
https://pubmed.ncbi.nlm.nih.gov/29314462
Autor:
Andrew Nolting, Daniel Zewge, Jacob M. Janey, Zhiguo J. Song, David M. Tellers, Paul N. Devine, Steven F. Oliver, David M. Tschaen, Dietrich Steinhuebel, Peter G. Dormer
Publikováno v:
Organic Process Research & Development. 18:423-430
A practical synthesis of a macrocyclic HCV protease inhibitor, MK-1220, is described. The key features are a new synthesis of the trisubstituted isoquinoline, Sonogashira fragment coupling, and a high-yielding, 18-membered macrolactam formation.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cbf334ca5638136824f43950b4968800
https://doi.org/10.1021/op400331j
https://doi.org/10.1021/op400331j
Autor:
Ian W. Davies, Paul N. Devine, Robert A. Reamer, David M. Tschaen, Fei Zhang, Daniel Zewge, Jeffrey T. Kuethe, David R. Lieberman, Zhihui Peng, Kevin M. Belyk, David M. Tellers, Guy R. Humphrey, Peter G. Dormer, Michel Journet, Andrew Nolting, Marjorie S. Waters, Dalian Zhao, Zhiguo J. Song
Publikováno v:
The Journal of Organic Chemistry. 76:7804-7815
Development of a practical synthesis of MK-7009, a 22-membered macrocycle, is described. A variety of ring-closing strategies were evaluated, including ring-closing metathesis, intermolecular palladium-catalyzed cross-couplings, and macrolactamizatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d1dc6683cb1f9b4cbaa077ffc9b2d32f
https://doi.org/10.1021/jo2011494
https://doi.org/10.1021/jo2011494
Autor:
Zhuqing Liu, Edward C. Sherer, Joseph Shpungin, James Cuff, Feng Xu, Claire Lee, Candice A. Sherwood, Shane W. Krska, Richard Desmond, C. Scott Shultz, Peter G. Dormer
Publikováno v:
Tetrahedron Letters. 52:1685-1688
An efficient preparation of highly enantiomerically enriched aryl β-hydroxy α-amino esters via dynamic kinetic resolution (DKR), asymmetric transfer hydrogenation of α-amino β-keto esters is described. The anti β-hydroxyl α-amino esters were ob
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c11043892d2f730ffbbc59303ea25213
https://doi.org/10.1016/j.tetlet.2011.01.146
https://doi.org/10.1016/j.tetlet.2011.01.146
Autor:
Yongkui Sun, Peter G. Dormer, Dale R. Mowrey, Fouzia Machrouhi, Jeffrey V. Mitten, Todd D. Nelson, Shane W. Krska
Publikováno v:
Tetrahedron. 65:8987-8994
Asymmetric hydrogenation of a vinyl fluoride derivative gives efficient access to enantioenriched 1,3,4-trisubstituted piperidine 1 with a stereogenic alkyl fluoride center. Extensive catalyst screening across transition metals and chiral ligands ide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1a74e9002de95b06bdaea84844b525cf
https://doi.org/10.1016/j.tet.2009.06.105
https://doi.org/10.1016/j.tet.2009.06.105