Zobrazeno 1 - 10
of 144
pro vyhledávání: '"Peter A. Crawford"'
Autor:
Renee M. Mahr, Snehalata Jena, Sereen K. Nashif, Alisa B. Nelson, Adam J. Rauckhorst, Ferrol I. Rome, Ryan D. Sheldon, Curtis C. Hughey, Patrycja Puchalska, Micah D. Gearhart, Eric B. Taylor, Peter A. Crawford, Sarah A. Wernimont
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-17 (2023)
Abstract Cytotrophoblasts fuse to form and renew syncytiotrophoblasts necessary to maintain placental health throughout gestation. During cytotrophoblast to syncytiotrophoblast differentiation, cells undergo regulated metabolic and transcriptional re
Externí odkaz:
https://doaj.org/article/4fec55be4690428399d950a1b56a17ae
Autor:
Madelyn Blake, Patrycja Puchalska, Felipe Kazmirczak, Jeffrey Blake, Ryan Moon, Thenappan Thenappan, Peter A. Crawford, Kurt W. Prins
Publikováno v:
Heliyon, Vol 9, Iss 11, Pp e22227- (2023)
Background: Ketone bodies are pleotropic metabolites that play important roles in multiple biological processes ranging from bioenergetics to inflammation regulation via suppression of the NLRP3 inflammasome, and epigenetic modifications. Ketone bodi
Externí odkaz:
https://doaj.org/article/0ef249094f134365bc62e5bfac32154e
Autor:
Xiaoyu Zhang, Yan Liu, Froylan Sosa, Sumedha Gunewardena, Peter A. Crawford, Amanda C. Zielen, Kyle E. Orwig, Ning Wang
Publikováno v:
Cell Reports, Vol 42, Iss 7, Pp 112749- (2023)
Summary: Nutrient starvation drives yeast meiosis, whereas retinoic acid (RA) is required for mammalian meiosis through its germline target Stra8. Here, by using single-cell transcriptomic analysis of wild-type and Stra8-deficient juvenile mouse germ
Externí odkaz:
https://doaj.org/article/4068a4d2c9b94e0c84c34f72612e532a
Autor:
Sereen K. Nashif, Renee M. Mahr, Snehalata Jena, Seokwon Jo, Alisa B. Nelson, Danielle Sadowski, Peter A. Crawford, Patrycja Puchalska, Emilyn U. Alejandro, Micah D. Gearhart, Sarah A. Wernimont
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Metformin is a widely prescribed medication whose mechanism of action is not completely defined and whose role in gestational diabetes management remains controversial. In addition to increasing the risk of fetal growth abnormalities and preeclampsia
Externí odkaz:
https://doaj.org/article/ec144421216f40e890797827bc132634
Publikováno v:
Journal of Lipid Research, Vol 63, Iss 5, Pp 100201- (2022)
FA esters of hydroxy FAs (FAHFAs) are lipokines with extensive structural and regional isomeric diversity that impact multiple physiological functions, including insulin sensitivity and glucose homeostasis. Because of their low molar abundance, FAHFA
Externí odkaz:
https://doaj.org/article/ea68d57e609a49d9be74eb5769a5bd12
Autor:
Alisa B. Nelson, Lisa S. Chow, David B. Stagg, Jacob R. Gillingham, Michael D. Evans, Meixia Pan, Curtis C. Hughey, Chad L. Myers, Xianlin Han, Peter A. Crawford, Patrycja Puchalska
Publikováno v:
JCI Insight, Vol 7, Iss 7 (2022)
Background Responses of the metabolome to acute aerobic exercise may predict maximum oxygen consumption (VO2max) and longer-term outcomes, including the development of diabetes and its complications.Methods Serum samples were collected from overweigh
Externí odkaz:
https://doaj.org/article/09d2f486133740c39628e0611a0437d6
Autor:
Ilona Tietzová, Kirk Twaroski, Cindy Eide, Julie H. Ostrander, Peter A. Crawford, Jakub Tolar
Publikováno v:
European Medical Journal Dermatology, Vol 8, Iss 1, Pp 75-83 (2020)
Background: Recessive dystrophic epidermolysis bullosa (RDEB) and junctional EB (JEB) are inherited disorders characterised by fragility and blistering of epithelial tissues leading to pain, pruritus, and adherent scarring. The severity and chronic n
Externí odkaz:
https://doaj.org/article/b2fafe98800c4d7980d08a23819aa10d
Autor:
David B. Stagg, Jacob R. Gillingham, Alisa B. Nelson, Justin E. Lengfeld, D. André d’Avignon, Patrycja Puchalska, Peter A. Crawford
Publikováno v:
Molecular Metabolism, Vol 53, Iss , Pp 101269- (2021)
Objective: Throughout the last decade, interest has intensified in intermittent fasting, ketogenic diets, and exogenous ketone therapies as prospective health-promoting, therapeutic, and performance-enhancing agents. However, the regulatory roles of
Externí odkaz:
https://doaj.org/article/fb28ca13065f4109842eeb324b00f0c4
Publikováno v:
Cancer & Metabolism, Vol 6, Iss 1, Pp 1-9 (2018)
Abstract Background Recent in vitro and in vivo work has shown that lactate provides an important source of carbon for metabolic reactions in cancer cell mitochondria. An interesting question is whether lactate is oxidized by lactate dehydrogenase (L
Externí odkaz:
https://doaj.org/article/2c6d6d7c1ef24650873c5592907bd02e
Autor:
Patrycja Puchalska, Xiaojing Huang, Shannon E. Martin, Xianlin Han, Gary J. Patti, Peter A. Crawford
Publikováno v:
iScience, Vol 9, Iss , Pp 298-313 (2018)
Summary: We apply stable isotope tracing, mass-spectrometry-based untargeted metabolomics, to reveal the biochemical space labeled by 13C-substrates in bone-marrow-derived macrophages. At the pathway level, classically (lipopolysaccharide [LPS]-polar
Externí odkaz:
https://doaj.org/article/4ee778853d6c418ba1db5eba63a72d99