Zobrazeno 1 - 10
of 408
pro vyhledávání: '"Peter A. Campochiaro"'
Autor:
Raquel Lima e Silva, Adam C. Mirando, Stephany Y. Tzeng, Jordan J. Green, Aleksander S. Popel, Niranjan B. Pandey, Peter A. Campochiaro
Publikováno v:
iScience, Vol 26, Iss 2, Pp 106078- (2023)
Summary: AXT107, a collagen-derived peptide that binds integrins αvβ3 and α5β1 with high affinity, suppresses vascular endothelial growth factor (VEGF) signaling, promotes angiopoietin 2-induced Tie2 activation, and suppresses neovascularization
Externí odkaz:
https://doaj.org/article/78fca1949d7a467b812527971c29c555
Autor:
Valeria E. Lorenc, Raquel Lima e Silva, Sean F. Hackett, Seth D. Fortmann, Yuanyuan Liu, Peter A. Campochiaro
Publikováno v:
FASEB BioAdvances, Vol 2, Iss 4, Pp 219-233 (2020)
Abstract In patients with macular edema due to ischemic retinopathy, aqueous levels of hepatocyte growth factor (HGF) correlate with edema severity. We tested whether HGF expression and activity in mice with oxygen‐induced ischemic retinopathy supp
Externí odkaz:
https://doaj.org/article/55eb1a2a210e42579ab4fb3a085186e8
Autor:
Hiroki Tsujinaka, Jie Fu, Jikui Shen, Yun Yu, Zibran Hafiz, Joshua Kays, David McKenzie, Delia Cardona, David Culp, Ward Peterson, Brian C. Gilger, Christopher S. Crean, Jin-Zhong Zhang, Yogita Kanan, Weiling Yu, Jeffrey L. Cleland, Ming Yang, Justin Hanes, Peter A. Campochiaro
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Neovascular age-related macular degeneration and diabetic retinopathy are currently treated with repeated intravitreous injections of VEGF neutralizing proteins. Here the authors develop a microparticle-loaded tyrosine kinase inhibitor therapy, which
Externí odkaz:
https://doaj.org/article/2ec68ea8afa548e39d54ab7c4b1ff7de
Autor:
Paulina M. Wojnarowicz, Raquel Lima e Silva, Masayuki Ohnaka, Sang Bae Lee, Yvette Chin, Anita Kulukian, Sung-Hee Chang, Bina Desai, Marta Garcia Escolano, Riddhi Shah, Marta Garcia-Cao, Sijia Xu, Rashmi Kadam, Yehuda Goldgur, Meredith A. Miller, Ouathek Ouerfelli, Guangli Yang, Tsutomu Arakawa, Steven K. Albanese, William A. Garland, Glenn Stoller, Jaideep Chaudhary, Larry Norton, Rajesh Kumar Soni, John Philip, Ronald C. Hendrickson, Antonio Iavarone, Andrew J. Dannenberg, John D. Chodera, Nikola Pavletich, Anna Lasorella, Peter A. Campochiaro, Robert Benezra
Publikováno v:
Cell Reports, Vol 29, Iss 1, Pp 62-75.e7 (2019)
Summary: Id helix-loop-helix (HLH) proteins (Id1–4) bind E protein bHLH transcription factors, preventing them from forming active transcription complexes that drive changes in cell states. Id proteins are primarily expressed during development to
Externí odkaz:
https://doaj.org/article/95d35ea0d3dd4fce8521d6c45f7d1b30
Autor:
Adam C. Mirando, Raquel Lima e Silva, Zenny Chu, Peter A. Campochiaro, Niranjan B. Pandey, Aleksander S. Popel
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 14, p 5142 (2020)
Persistent inflammation is a complication associated with many ocular diseases. Changes in ocular vessels can amplify disease responses and contribute to vision loss by influencing the delivery of leukocytes to the eye, vascular leakage, and perfusio
Externí odkaz:
https://doaj.org/article/b1f7088a53f64b59a1a90b18e7aad98b
Autor:
Yogita Kanan, Sean F. Hackett, Henry T. Hsueh, Mahmood Khan, Laura M. Ensign, Peter A. Campochiaro
Publikováno v:
Free Radical Biology and Medicine. 198:118-122
Autor:
Susie trotochaud, Xiangrong Kong, Carl A. Latkin, Fahd Naufal, Cory Dorfman, Peter A. Campochiaro
Publikováno v:
Ophthalmic Genet
BACKGROUND: Clinical trials for retinitis pigmentosa (RP) likely require long follow-ups because of the slow progression of RP. Understanding patients’ attitudes toward participation in a long trial and their acceptability of strategies aimed at pr
Publikováno v:
Trends in Molecular Medicine. 28:347-349
Faricimab, a bispecific antibody that targets the endothelial cell growth factors vascular endothelial growth factor-A (VEGF-A) and angiopoietin-2 (Angpt2), was recently approved for treating neovascular age-related macular degeneration and diabetic
Publikováno v:
Gene therapy
Suprachoroidal injection provides a new route of delivery for AAV vectors to retinal pigmented epithelial cells and photoreceptors that can be done in an outpatient setting and is less invasive and potentially safer than subretinal injection, the mos
Publikováno v:
Lancet
Acute retinal vascular occlusions are common causes of visual impairment. Although both retinal artery occlusions and retinal vein occlusions are associated with increased age and cardiovascular risk factors, their pathophysiology, systemic implicati