Updating exposure assessment for skin sensitization quantitative risk assessment for fragrance materials

Autor: Ian R. White, Alain Khaiat, Peter Griem, Benjamin P C Smith, Nicola Gilmour, David A. Basketter, Helmut Greim, Peter A. Cadby, Graham Ellis, A.M. Api, Thomas Rustemeyer, John O'Brien, Bob Safford, Petra S. Kern, Cindy A. Ryan, Matthias Vey, James W. Bridges

Publikováno v: Api, A M, Basketter, D, Bridges, J, Cadby, P, Ellis, G, Gilmour, N, Greim, H, Griem, P, Kern, P, Khaiat, A, O'Brien, J, Rustemeyer, T, Ryan, C, Safford, B, Smith, B, Vey, M & White, I R 2020, ' Updating exposure assessment for skin sensitization quantitative risk assessment for fragrance materials ', Regulatory Toxicology and Pharmacology, vol. 118, 104805 . https://doi.org/10.1016/j.yrtph.2020.104805
Regulatory Toxicology and Pharmacology, 118:104805. Academic Press Inc.

In 2008, a proposal for assessing the risk of induction of skin sensitization to fragrance materials Quantitative Risk Assessment 1 (QRA1) was published. This was implemented for setting maximum limits for fragrance materials in consumer products. Ho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ad42452a64d804f0517f1fa3af8578b
https://pubmed.ncbi.nlm.nih.gov/33075411

Identification of the causes of an allergic reaction to a fragranced consumer product

Autor: Carol Surot, Barbara Hall, Peter A. Cadby, Matthias Vey, Graham Ellis

Publikováno v: Flavour and Fragrance Journal. 26:2-6

Identification of substances in consumer products (more particularly fragrance allergens in cosmetics) that are responsible for cases of contact dermatitis is of key importance for the patient and also for industry so that appropriate risk management

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::db4d6c0660688089510d5dea43a6d300
https://doi.org/10.1002/ffj.2021

Dermal sensitization quantitative risk assessment (QRA) for fragrance ingredients

Autor: A.M. Api, Peter A. Cadby, Robert J. Safford, Peter Griem, Cindy A. Ryan, Marie-France Cano, David A. Basketter, Pauline McNamee, Graham Ellis, G. Frank Gerberick

Publikováno v: Regulatory toxicology and pharmacology : RTP. 52(1)

Based on chemical, cellular, and molecular understanding of dermal sensitization, an exposure-based quantitative risk assessment (QRA) can be conducted to determine safe use levels of fragrance ingredients in different consumer product types. The key

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5edfbebefab76177208de108e63f486e
https://pubmed.ncbi.nlm.nih.gov/18406028

Consumer exposure to fragrance ingredients: providing estimates for safety evaluation

Autor: Peter A. Cadby, William Troy, Matthias Vey

Publikováno v: Regulatory toxicology and pharmacology : RTP. 36(3)

To fully apply already published procedures for the safety evaluation of fragrance ingredients, it is necessary to estimate exposure through different routes and leading to different potential endpoints. Worst-case scenario calculations indicate that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6fbd9f5d8aef89056073ec6d2c12126
https://pubmed.ncbi.nlm.nih.gov/12473409

Evaluation of models for the mechanism of action of 4-hydroxyphenylpyruvate dioxygenase

Autor: Charles W. Jefford, Peter A. Cadby

Publikováno v: Experientia. 37:1134-1137

3-Hydroxyphenylpyruvic acid was oxygenated with various complexes of oxygen with Fe2+, superoxide ion, hydroperoxide anion, triplet and singlet oxygen. Oxidation occurred giving varying amounts of the 4-hydroxy derivatives of benzaldehyde, benzoic ac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::497d47b6ae573b6b69cfd4b119f0a773
https://doi.org/10.1007/bf01989880