Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Peter A. Blomgren"'
Autor:
Eric B. Lansdon, Helen Yu, Kropf Jeffrey E, Peter A. Blomgren, Jennifer R. Lo, Guoju Geng, Kevin S. Currie, Aaron C. Schmitt, Jayaraman Chandrasekhar, Chris Pohlmeyer, Scott A. Mitchell, Seung H. Lee, Wanchi Fung, Sarah Wise, Jin-Ming Xiong, Zhongdong Zhao, Randall Mark Jones, Kimberly Suekawa-Pirrone, Julie Di Paolo, Bernard P. Murray, Carmen Ip, Jianjun Xu
Publikováno v:
ACS Med Chem Lett
[Image: see text] Spleen tyrosine kinase (SYK) is a critical regulator of signaling in a variety of immune cell types such as B-cells, monocytes, and macrophages. Accordingly, there have been numerous efforts to identify compounds that selectively in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83a219ff1dd97e346313a9eebe517807
https://pubmed.ncbi.nlm.nih.gov/32292557
https://pubmed.ncbi.nlm.nih.gov/32292557
Autor:
J. Andrew Whitney, Kevin S. Currie, Deborah Maclin, James Barbosa, Kropf Jeffrey E, Ann Marie Rossi, Eric B. Lansdon, Jennifer Macaluso, Scott A. Mitchell, Hong Rong, Tony Lee, Jianjun Xu, Steve Gallion, Patricia Maciejewski, Julie Di Paolo, Peter A. Blomgren, Zhongdong Zhao
Publikováno v:
Journal of Medicinal Chemistry. 57:3856-3873
Spleen tyrosine kinase (Syk) is an attractive drug target in autoimmune, inflammatory, and oncology disease indications. The most advanced Syk inhibitor, R406, 1 (or its prodrug form fostamatinib, 2), has shown efficacy in multiple therapeutic indica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2b4e26bd97c65595d3ff3afda0fbb23
https://doi.org/10.1021/jm500228a
https://doi.org/10.1021/jm500228a
Publikováno v:
Tetrahedron. 64:645-651
A simple, convenient and high-yielding one-pot method for the synthesis of 2-heterocycle-substituted imidazoles from the corresponding nitriles has been developed. The procedure is easily scaleable and the workup does not involve chromatography. This
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8e5fcccb3f2c7948253307b36f9536d3
https://doi.org/10.1016/j.tet.2007.11.009
https://doi.org/10.1016/j.tet.2007.11.009
Publikováno v:
Tetrahedron. 56:2139-2144
Using the heterogeneous catalyst ‘Ni/C’, biaryl bonds can be made between functionalized aryl chlorides and boronic acids in good isolated yields. A standard set of conditions has been developed which applies to a variety of reaction partners.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e2fd3bcb78bbbddfa63e66c5080912f3
https://doi.org/10.1016/s0040-4020(99)01096-0
https://doi.org/10.1016/s0040-4020(99)01096-0
Publikováno v:
Inorganica Chimica Acta. 296:164-169
Carbon–carbon bond-forming reactions between aryl chlorides and Grignard reagents can be catalyzed under heterogeneous conditions using nickel on charcoal.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::93f00982169fcea78c7af94ea0c565b4
https://doi.org/10.1016/s0020-1693(99)00388-6
https://doi.org/10.1016/s0020-1693(99)00388-6
Publikováno v:
Tetrahedron Letters. 40:197-200
Treatment of substituted aryl chlorides with functionalized organozinc iodides in the presence of catalytic amounts of a soluble Ni(0) source lead to efficient displacement reactions.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::88250a9758eb59c1a70dda4efa7973ca
https://doi.org/10.1016/s0040-4039(98)02271-0
https://doi.org/10.1016/s0040-4039(98)02271-0
Publikováno v:
Tetrahedron. 54:6999-7012
Treatment of selected chloromethylated heteroaromatics, including pyridines, thiophenes, and furans, with vinyl alanes or vinyl zirconocenes in the presence of Ni(0) results in E-allylated products in good yields.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::041d15073bf4b6ccc25a8108352d30e9
https://doi.org/10.1016/s0040-4020(98)00342-1
https://doi.org/10.1016/s0040-4020(98)00342-1
Publikováno v:
ChemInform. 29
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d19982a4f401ab5caaf2afe1d14b0d23
https://doi.org/10.1002/chin.199840058
https://doi.org/10.1002/chin.199840058
Publikováno v:
ChemInform. 30
Treatment of substituted aryl chlorides with functionalized organozinc iodides in the presence of catalytic amounts of a soluble Ni(0) source lead to efficient displacement reactions.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1abc8b8d7dad5b5e9695f7e2b1062183
https://doi.org/10.1002/chin.199911077
https://doi.org/10.1002/chin.199911077
Autor:
Peter A. Blomgren, Bruce H. Lipshutz
Publikováno v:
ChemInform. 30
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ee2e4a1208d603a17590ab8ceb54c125
https://doi.org/10.1002/chin.199941049
https://doi.org/10.1002/chin.199941049