Zobrazeno 1 - 10
of 128
pro vyhledávání: '"Peter A. Beal"'
Autor:
Aashrita Manjunath, Jeff Cheng, Kristen B Campbell, Casey S. Jacobsen, Herra G. Mendoza, Leila Bierbaum, Victorio Jauregui-Matos, Erin E. Doherty, Andrew J. Fisher, Peter A. Beal
Publikováno v:
Biomolecules, Vol 14, Iss 10, p 1229 (2024)
Adenosine Deaminases Acting on RNA (ADARs) are members of a family of RNA editing enzymes that catalyze the conversion of adenosine into inosine in double-stranded RNA (dsRNA). ADARs’ selective activity on dsRNA presents the ability to correct muta
Externí odkaz:
https://doaj.org/article/74f0470ef24d475282890dd62e8033e0
Autor:
SeHee Park, Erin E. Doherty, Yixuan Xie, Anil K. Padyana, Fang Fang, Yue Zhang, Agya Karki, Carlito B. Lebrilla, Justin B. Siegel, Peter A. Beal
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Human ADAR proteins are responsible for RNA editing, conversion of adenosine to inosine in double-stranded RNA. Here the authors report a previously unknown zinc ion-binding site in the catalytic domain of human ADAR1 using high throughput mutagenesi
Externí odkaz:
https://doaj.org/article/2cab59460beb46e3b35941eb8878c251
Publikováno v:
Molecules, Vol 20, Iss 3, Pp 4148-4161 (2015)
Tethering has been extensively used to study small molecule interactions with proteins through reversible disulfide bond forming reactions to cysteine residues. We describe the adaptation of Tethering to the study of small molecule binding to RNA usi
Externí odkaz:
https://doaj.org/article/7fafe09261c04f1795fc26f9cf7667ff
Publikováno v:
Biochemistry. 62:1376-1387
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0ec52e82174c0ac1ba46d3569700d339
https://doi.org/10.1021/acs.biochem.2c00686
https://doi.org/10.1021/acs.biochem.2c00686
Autor:
Erin E Doherty, Agya Karki, Xander E Wilcox, Herra G Mendoza, Aashrita Manjunath, Victorio Jauregui Matos, Andrew J Fisher, Peter A Beal
Publikováno v:
Nucleic Acids Research. 50:10857-10868
ADARs (adenosine deaminases acting on RNA) can be directed to sites in the transcriptome by complementary guide strands allowing for the correction of disease-causing mutations at the RNA level. However, ADARs show bias against editing adenosines wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90a4e78948fe451c3f349cd543423ea1
https://doi.org/10.1093/nar/gkac897
https://doi.org/10.1093/nar/gkac897
Autor:
Casey S. Jacobsen, Prince Salvador, John F. Yung, Sabrina Kragness, Herra G. Mendoza, Gail Mandel, Peter A. Beal
Publikováno v:
ACS Chemical Biology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3e2daa8a936811dcbe150f42f739cae0
https://doi.org/10.1021/acschembio.3c00107
https://doi.org/10.1021/acschembio.3c00107
Autor:
Hannah F. Brinkman, Victorio Jauregui Matos, Herra G. Mendoza, Erin E. Doherty, Peter A. Beal
Publikováno v:
RSC chemical biology, vol 4, iss 1
Adenosine deaminases that act on RNA (ADARs) can be directed to predetermined sites in transcriptomes by forming duplex structures with exogenously delivered guide RNAs (gRNAs). They can then catalyze the hydrolytic deamination of adenosine to inosin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42ea52a40a829c716db4890f6c286679
https://escholarship.org/uc/item/0kj944p5
https://escholarship.org/uc/item/0kj944p5
Autor:
Kevin M. Pham, Peter A. Beal
Publikováno v:
Handbook of Chemical Biology of Nucleic Acids ISBN: 9789811613135
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::40a3f16ddf3e27ff031c29a2d872ea94
https://doi.org/10.1007/978-981-16-1313-5_41-1
https://doi.org/10.1007/978-981-16-1313-5_41-1
Autor:
Erin E, Doherty, Peter A, Beal
Publikováno v:
Molecular Therapy. 30:2117-2119
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f973f6b65461a2681282b01b601d8dad
https://doi.org/10.1016/j.ymthe.2022.04.005
https://doi.org/10.1016/j.ymthe.2022.04.005
Autor:
Theodore M Hill, Ronald B. Emeson, Peter A. Beal, Vandana M Gaded, Turnee N Malik, Erin E Doherty
Publikováno v:
Nucleic Acids Research
Nucleic acids research, vol 49, iss 7
Nucleic acids research, vol 49, iss 7
The hydrolytic deamination of adenosine-to-inosine (A-to-I) by RNA editing is a widespread post-transcriptional modification catalyzed by the adenosine deaminase acting on RNA (ADAR) family of proteins. ADAR-mediated RNA editing modulates cellular pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81d828d256bb0c7074181004ca34bc18
http://europepmc.org/articles/PMC8053123
http://europepmc.org/articles/PMC8053123