Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Peter A. Robson"'
Autor:
Qunfang Zhou, Allen C. Clermont, Peter A. Robson, Nivetha Murugesan, D. Michael Evans, Louise J. Rushbrooke, Edward P. Feener, Takeshi Kita, Lloyd Paul Aiello
Publikováno v:
Investigative Ophthalmology & Visual Science
PURPOSE Plasma kallikrein is a serine protease and circulating component of inflammation, which exerts clinically significant effects on vasogenic edema. This study examines the role of plasma kallikrein in VEGF-induced retinal edema. METHODS Intravi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72dfd90044c2c1608887046f5d958264
https://pubmed.ncbi.nlm.nih.gov/27138737
https://pubmed.ncbi.nlm.nih.gov/27138737
Autor:
Pitt Gary Robert William, Rooker David Philip, Robert Haigh, Andrew M. Penson, Andrzej Roman Batt, André Tartar, Peter A. Robson, Julie E. Trim, Michael Bryan Roe, Yea Christopher Martyn
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:4585-4589
A library of compounds targeted to the vasopressin/oxytocin family of receptors was screened for activity at a cloned human oxytocin receptor using a reporter gene assay. Potency and selectivity were optimised to afford compound 39, EC50 = 33 nM. Thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b274a980a46e270e06583229d7027902
https://doi.org/10.1016/j.bmcl.2004.04.107
https://doi.org/10.1016/j.bmcl.2004.04.107
Autor:
Catherine Sautes, Richard A. Williamson, Erik Ruuth, Claude Fudali, Peter A. Robson, Elizabeth Anne Kuo, Jean-Michel Bruneau, Katherine Woodward, Robert Westwood, Sylviane Spinella-Jaegle, Yea Christopher Martyn
Publikováno v:
Biochemical Journal. 336:299-303
Leflunomide is currently in phase-III clinical trials for the treatment of rheumatoid arthritis. In this study, we have focused our efforts on the study of the mechanism of action of the active metabolite of leflunomide, A77 1726, in cells and tissue
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c03d369f43e17c391b41722f8b52edd9
https://doi.org/10.1042/bj3360299
https://doi.org/10.1042/bj3360299
Autor:
S. Spinella-Jaegle, A. B. Hambleton, Adam P. Curnock, P. Hambleton, K. Woodward, J.-M. Bruneau, Erik Ruuth, Yea Christopher Martyn, E. A. Kuo, O. Courtin, Robert Westwood, D. Moss, T. A. Thomson, Catherine Sautes, Richard A. Williamson, Suresh Gadher, Peter A. Robson, P. Morand, T. Hercend
Publikováno v:
Journal of Biological Chemistry. 270:22467-22472
A protein with high affinity (Kd 12 nM) for the immunomodulatory compound A77 1726 has been isolated from mouse spleen and identified as the mitochondrial enzyme dihydroorotate dehydrogenase (EC 1.3.3.1). The purified protein had a pI 9.6-9.8 and a s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6b93638a1f9d60183442d6f3f2cc101
https://doi.org/10.1074/jbc.270.38.22467
https://doi.org/10.1074/jbc.270.38.22467
Autor:
James Barnett, Andy Sheppard, Andy J Baxter, Robert Haigh, Doreen Mary Ashworth, John Horton, Janice D Broadbridge, Michael Bryan Roe, Christine Elizabeth Allan, Richard Jeremy Franklin, Sally L Hampton, Peter A. Robson, Graeme San Diego Semple, Andy M Penson, Pierre Riviere, Rooker David Philip, Peter Hudson, Pitt Gary Robert William, Yea Christopher Martyn, Paul David Jenkins
Publikováno v:
Journal of medicinal chemistry. 51(24)
Vasopressin (AVP) is a hormone that stimulates an increase in water permeability through activation of V2 receptors in the kidney. The analogue of AVP, desmopressin, has proven an effective drug for diseases where a reduction of urine output is desir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5811e23f6391edc618cca30c4ed2af9b
https://pubmed.ncbi.nlm.nih.gov/19053774
https://pubmed.ncbi.nlm.nih.gov/19053774
Autor:
Robert Haigh, Pierre Riviere, Jacek Stalewski, Audrey Aebi, Claudio D. Schteingart, Robert Galyean, Pierre Broqua, Jerzy Trojnar, Graeme Semple, Guangcheng Jiang, Jean Louis Junien, Peter A. Robson, John Dykert, Michel L. Aubert, Karen O. Akinsanya, Jean Rivier
Publikováno v:
Journal of Medicinal Chemistry, Vol. 44, No 3 (2001) pp. 453-67
A series of antagonists of gonadotropin-releasing hormone (GnRH) of the general formula Ac-D2Nal-D4Cpa-D3Pal-Ser-4Aph/4Amf(P)-D4Aph/D4Amf(Q)-Leu-ILys-Pro-DAla-NH2 was synthesized, characterized, and screened for duration of inhibition of luteinizing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32fb0a31db7b3f1512d23330fda884d5
https://archive-ouverte.unige.ch/unige:56087
https://archive-ouverte.unige.ch/unige:56087
Autor:
Celine Marguerite Simone Heeney, Peter A. Robson, Regent Laporte, Robert Haigh, Pierre Broqua, Andrzej Roman Batt, André Tartar, Peter Hudson, Rooker David Philip, Chris Yea, Michael Bryan Roe, Pitt Gary Robert William, Doreen Mary Ashworth, Andrew John Baxter, Andrew M. Penson
Publikováno v:
Drugs of the Future. 31:345
Oxytocin is a neurohypophyseal hormone that acts at the oxytocin receptor localized both peripherally and centrally and is particularly highly expressed in the pregnant human myometrium. Synthetic oxytocin has long been used to induce labor and oxyto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7c9a35c1fd8fb3d616cdec730b4ad6b8
https://doi.org/10.1358/dof.2006.031.04.980655
https://doi.org/10.1358/dof.2006.031.04.980655
Autor:
Christopher M. Yea, Christine E. Allan, Doreen M. Ashworth, James Barnett, Andy J. Baxter, Janice D. Broadbridge, Richard J. Franklin, Sally L. Hampton, Peter Hudson, John A. Horton, Paul D. Jenkins, Andy M. Penson, Gary R. W. Pitt, Pierre Rivière, Peter A. Robson, David P. Rooker, Graeme Semple, Andy Sheppard, Robert M. Haigh, Michael B. Roe
Publikováno v:
Journal of Medicinal Chemistry; Dec2008, Vol. 51 Issue 24, p8124-8134, 11p
Autor:
G. W. Danswan, I. R. Ager, Peter A. Robson, Alan Charles Barnes, Saroop S. Matharu, P. D. Kennewell, D. P. Kay, David Alun Rowlands, P. W. Hairsine, R. Westwolld, P. Miller, W. R. Tully
Publikováno v:
ChemInform. 19
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d3369738b4a4c91474cfd6bbc6496a17
https://doi.org/10.1002/chin.198843216
https://doi.org/10.1002/chin.198843216