Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Peter A Lind"'
Autor:
Jennifer T Pentz, Peter A Lind
Publikováno v:
PLoS Genetics, Vol 17, Iss 8, p e1009722 (2021)
Experimental evolution with microbes is often highly repeatable under identical conditions, suggesting the possibility to predict short-term evolution. However, it is not clear to what degree evolutionary forecasts can be extended to related species
Externí odkaz:
https://doaj.org/article/5c0c6ecde8b944828352ead80825b32f
Publikováno v:
eLife, Vol 8 (2019)
Predicting evolutionary change poses numerous challenges. Here we take advantage of the model bacterium Pseudomonas fluorescens in which the genotype-to-phenotype map determining evolution of the adaptive ‘wrinkly spreader’ (WS) type is known. We
Externí odkaz:
https://doaj.org/article/19c4600ca5874089a8c0a74e83bd48f8
Publikováno v:
eLife, Vol 4 (2015)
Replicate populations of natural and experimental organisms often show evidence of parallel genetic evolution, but the causes are unclear. The wrinkly spreader morph of Pseudomonas fluorescens arises repeatedly during experimental evolution. The muta
Externí odkaz:
https://doaj.org/article/4e455c31dd594cb69ce03c120d61312e
Autor:
Peter A Lind, Dan I Andersson
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e63373 (2013)
We previously reported that the distribution of fitness effects for non-synonymous and synonymous mutations in Salmonella typhimurium ribosomal proteins S20 and L1 are similar, suggesting that fitness constraints are present at the level of mRNA. Her
Externí odkaz:
https://doaj.org/article/7806a939e2e34be2a6768482fb06b5ad
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract The evolutionary transition from unicellularity to multicellularity was a key innovation in the history of life. Experimental evolution is an important tool to study the formation of undifferentiated cellular clusters, the likely first step
Externí odkaz:
https://doaj.org/article/3572edbb367c46478f9549b96fe3fe53
Autor:
Meike T. Wortel, Deepa Agashe, Susan F. Bailey, Claudia Bank, Karen Bisschop, Thomas Blankers, Johannes Cairns, Enrico Sandro Colizzi, Davide Cusseddu, Michael M. Desai, Bram vanDijk, Martijn Egas, Jacintha Ellers, Astrid T. Groot, David G. Heckel, Marcelle L. Johnson, Ken Kraaijeveld, Joachim Krug, Liedewij Laan, Michael Lässig, Peter A. Lind, Jeroen Meijer, Luke M. Noble, Samir Okasha, Paul B. Rainey, Daniel E. Rozen, Shraddha Shitut, Sander J. Tans, Olivier Tenaillon, Henrique Teotónio, J. Arjan G. M. deVisser, Marcel E. Visser, Renske M. A. Vroomans, Gijsbert D. A. Werner, Bregje Wertheim, Pleuni S. Pennings
Publikováno v:
Evolutionary Applications, Vol 16, Iss 1, Pp 3-21 (2023)
Abstract Evolution has traditionally been a historical and descriptive science, and predicting future evolutionary processes has long been considered impossible. However, evolutionary predictions are increasingly being developed and used in medicine,
Externí odkaz:
https://doaj.org/article/5d350dba2ce2465ba41df12f9a33a44d
Autor:
Maria Bolther, Jeppe Henriksen, Mathias J. Holmberg, Marie K. Jessen, Mikael F. Vallentin, Frederik B. Hansen, Johanne M. Holst, Andreas Magnussen, Niklas S. Hansen, Cecilie M. Johannsen, Johannes Enevoldsen, Thomas H. Jensen, Lara L. Roessler, Peter Carøe Lind, Maibritt P. Klitholm, Mark A. Eggertsen, Philip Caap, Caroline Boye, Karol M. Dabrowski, Lasse Vormfenne, Maria Høybye, Mathias Karlsson, Ida R. Balleby, Marie S. Rasmussen, Kim Pælestik, Asger Granfeldt, Lars W. Andersen
Publikováno v:
Bolther, M, Henriksen, J, Holmberg, M J, Jessen, M K, Vallentin, M F, Hansen, F B, Holst, J M, Magnussen, A, Hansen, N S, Johannsen, C M, Enevoldsen, J, Jensen, T H, Roessler, L L, Carøe Lind, P, Klitholm, M P, Eggertsen, M A, Caap, P, Boye, C, Dabrowski, K M, Vormfenne, L, Høybye, M, Karlsson, M, Balleby, I R, Rasmussen, M S, Pælestik, K, Granfeldt, A & Andersen, L W 2022, ' Ventilation Strategies During General Anesthesia for Noncardiac Surgery : A Systematic Review and Meta-Analysis ', Anesthesia and Analgesia, vol. 135, no. 5, pp. 971-985 . https://doi.org/10.1213/ANE.0000000000006106
Bolther, M, Henriksen, J, Holmberg, M J, Jessen, M K, Valentin, M, Hansen, F B, Holst, J M, Magnussen, A, Hansen, N S, Johannsen, C M, Enevoldsen, J, Jensen, T H, Roessler, L L, Carøe Lind, P, Klitholm, M P, Eggertsen, M A, Caap, P, Boye, C, Dabrowski, K M, Vormfenne, L, Høybye, M, Karlsson, M, Balleby, I R, Rasmussen, M S, Pælestik, K, Granfeldt, A & Andersen, L W 2022, ' Ventilation Strategies During General Anesthesia for Noncardiac Surgery : A Systematic Review and Meta-Analysis ', Anesthesia and Analgesia, vol. 135, no. 5, pp. 971-985 . https://doi.org/10.1213/ANE.0000000000006106
Bolther, M, Henriksen, J, Holmberg, M J, Jessen, M K, Valentin, M, Hansen, F B, Holst, J M, Magnussen, A, Hansen, N S, Johannsen, C M, Enevoldsen, J, Jensen, T H, Roessler, L L, Carøe Lind, P, Klitholm, M P, Eggertsen, M A, Caap, P, Boye, C, Dabrowski, K M, Vormfenne, L, Høybye, M, Karlsson, M, Balleby, I R, Rasmussen, M S, Pælestik, K, Granfeldt, A & Andersen, L W 2022, ' Ventilation Strategies During General Anesthesia for Noncardiac Surgery : A Systematic Review and Meta-Analysis ', Anesthesia and Analgesia, vol. 135, no. 5, pp. 971-985 . https://doi.org/10.1213/ANE.0000000000006106
BACKGROUND: The optimal ventilation strategy during general anesthesia is unclear. This systematic review investigated the relationship between ventilation targets or strategies (eg, positive end-expiratory pressure [PEEP], tidal volume, and recruitm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92ee4b759bb052b1686ce2848eaab1e7
https://doi.org/10.1213/ane.0000000000006106
https://doi.org/10.1213/ane.0000000000006106
Autor:
T. Anthony Sun, Peter A. Lind
Publikováno v:
Microbiology. 169
Natural selection is commonly assumed to act on extensive standing genetic variation. Yet, accumulating evidence highlights the role of mutational processes creating this genetic variation: to become evolutionarily successful, adaptive mutants must n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67c3d68f6c4f22b163279f97b5e6f38f
https://doi.org/10.1099/mic.0.001323
https://doi.org/10.1099/mic.0.001323
Autor:
Marie K. Jessen, Mikael F. Vallentin, Mathias J. Holmberg, Maria Bolther, Frederik B. Hansen, Johanne M. Holst, Andreas Magnussen, Niklas S. Hansen, Cecilie M. Johannsen, Johannes Enevoldsen, Thomas H. Jensen, Lara L. Roessler, Peter C. Lind, Maibritt P. Klitholm, Mark A. Eggertsen, Philip Caap, Caroline Boye, Karol M. Dabrowski, Lasse Vormfenne, Maria Høybye, Jeppe Henriksen, Carl M. Karlsson, Ida R. Balleby, Marie S. Rasmussen, Kim Pælestik, Asger Granfeldt, Lars W. Andersen
Publikováno v:
Jessen, M K, Vallentin, M F, Holmberg, M J, Bolther, M, Hansen, F B, Holst, J M, Magnussen, A, Hansen, N S, Johannsen, C M, Enevoldsen, J, Jensen, T H, Roessler, L L, Lind, P C, Klitholm, M P, Eggertsen, M A, Caap, P, Boye, C, Dabrowski, K M, Vormfenne, L, Høybye, M, Henriksen, J, Karlsson, C M, Balleby, I R, Rasmussen, M S, Pælestik, K, Granfeldt, A & Andersen, L W 2022, ' Goal-directed haemodynamic therapy during general anaesthesia for noncardiac surgery : a systematic review and meta-analysis ', British Journal of Anaesthesia, vol. 128, no. 3, pp. 416-433 . https://doi.org/10.1016/j.bja.2021.10.046
Jessen, M K, Fink Vallentin, M, Holmberg, M J, Bolther, M, Hansen, F B, Holst, J M, Magnussen, A, Hansen, N S, Johannsen, C M, Enevoldsen, J, Jensen, T H, Roessler, L L, Lind, P C, Klitholm, M P, Eggertsen, M A, Caap, P, Boye, C, Dabrowski, K M, Vormfenne, L, Høybye, M, Henriksen, J, Karlsson, C M, Balleby, I R, Rasmussen, M S, Pælestik, K, Granfeldt, A & Andersen, L W 2022, ' Goal-directed haemodynamic therapy during general anaesthesia for noncardiac surgery : a systematic review and meta-analysis ', British Journal of Anaesthesia, vol. 128, no. 3, pp. 416-433 . https://doi.org/10.1016/j.bja.2021.10.046
Jessen, M K, Fink Vallentin, M, Holmberg, M J, Bolther, M, Hansen, F B, Holst, J M, Magnussen, A, Hansen, N S, Johannsen, C M, Enevoldsen, J, Jensen, T H, Roessler, L L, Lind, P C, Klitholm, M P, Eggertsen, M A, Caap, P, Boye, C, Dabrowski, K M, Vormfenne, L, Høybye, M, Henriksen, J, Karlsson, C M, Balleby, I R, Rasmussen, M S, Pælestik, K, Granfeldt, A & Andersen, L W 2022, ' Goal-directed haemodynamic therapy during general anaesthesia for noncardiac surgery : a systematic review and meta-analysis ', British Journal of Anaesthesia, vol. 128, no. 3, pp. 416-433 . https://doi.org/10.1016/j.bja.2021.10.046
BACKGROUND: During general anaesthesia for noncardiac surgery, there remain knowledge gaps regarding the effect of goal-directed haemodynamic therapy on patient-centred outcomes.METHODS: Included clinical trials investigated goal-directed haemodynami
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::887e594ed7299c80608f6c04273cab2f
https://doi.org/10.1016/j.bja.2021.10.046
https://doi.org/10.1016/j.bja.2021.10.046
Autor:
Asbjørn Graver Petersen, Peter Carøe Lind, Asger Granfeldt, Anne-Sophie Bonde Jensen, Susie Mogensen, Ulf Simonsen
Publikováno v:
Petersen, A, Lind, P C, Mogensen, S, Jensen, A-S B, Granfeldt, A & Simonsen, U 2022, ' Treatment with senicapoc, a K Ca 3.1 channel blocker, alleviates hypoxaemia in a mouse model of acute respiratory distress syndrome ', British Journal of Pharmacology, vol. 179, no. 10, pp. 2175-2192 . https://doi.org/10.1111/bph.15704
Background and Purpose: Acute respiratory distress syndrome (ARDS) is characterized by pulmonary oedema and severe hypoxaemia. We investigated whether genetic deficit or blockade of calcium-activated potassium (K Ca3.1) channels would counteract pulm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc837838b02ccbd48cc88d13afaf5252
https://doi.org/10.1111/bph.15704
https://doi.org/10.1111/bph.15704