Zobrazeno 1 - 10
of 142
pro vyhledávání: '"Peter A Doris"'
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2022)
Clinical use of the combination therapy of the neprilysin inhibitor sacubitril and angiotensin II type 1 receptor blocker valsartan is known to be associated with albuminuria. Albuminuria is both a risk factor for and an indicator of kidney injury. E
Externí odkaz:
https://doaj.org/article/b708b8b3effd43adb6548d8bfa46f871
Autor:
Piu Saha, Blair Mell, Rachel M. Golonka, Venugopal R. Bovilla, Ahmed A. Abokor, Xue Mei, Beng San Yeoh, Peter A. Doris, Andrew T. Gewirtz, Bina Joe, Matam Vijay-Kumar
Publikováno v:
Hypertension (Dallas, Tex. : 1979). 79(10)
Background:The spontaneously hypertensive rat (SHR) is extensively used to study hypertension. Gut microbiota dysbiosis is a notable feature in SHR for reasons unknown. Immunoglobulin A (IgA) is a major host factor required for gut microbiota homeost
Autor:
Theodore S. Kalbfleisch, Nahla A. Hussien AbouEl Ela, Kai Li, Wesley A. Brashear, Kelli J. Kochan, Andrew E. Hillhouse, Yaming Zhu, Isha S. Dhande, Eric J. Kline, Elizabeth A. Hudson, Terence D. Murphy, Françoise Thibaud-Nissen, Melissa L. Smith, Peter A. Doris
Publikováno v:
Hypertension. 80:138-146
Background: We report the creation and evaluation of a de novo assembly of the genome of the spontaneously hypertensive rat, the most widely used model of human cardiovascular disease. Methods: The genome is assembled from long read sequencing (PacBi
Autor:
Isha S. Dhande, Yaming Zhu, Sterling C. Kneedler, Aniket S. Joshi, M. John Hicks, Scott E. Wenderfer, Michael C. Braun, Peter A. Doris
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 9, Iss 5 (2020)
Background Spontaneously hypertensive rats of the stroke‐prone line (SHR‐A3) develop hypertensive renal disease as a result of naturally occurring genetic variation. Our prior work identified a single‐nucleotide polymorphism unique to SHR‐A3
Externí odkaz:
https://doaj.org/article/158be3b8e59544c4a23b2f5d90c5a669
Autor:
Tristan V de Jong, Yanchao Pan, Pasi Rastas, Daniel Munro, Monika Tutaj, Huda Akil, Chris Benner, Apurva S Chitre, William Chow, Vincenza Colonna, Clifton L Dalgard, Wendy M Demos, Peter A Doris, Erik Garrison, Aron Geurts, Hakan M Gunturkun, Victor Guryev, Thibaut Hourlier, Kerstin Howe, Jun Huang, Ted Kalbfleisch, Panjun Kim, Ling Li, Spencer Mahaffey, Fergal J Martin, Pejman Mohammadi, Ayse Bilge Ozel, Oksana Polesskaya, Michal Pravenec, Pjotr Prins, Jonathan Sebat, Jennifer R Smith, Leah C Solberg Woods, Boris Tabakoff, Alan Tracey, Marcela Uliano-Silva, Flavia Villani, Hongyang Wang, Burt M Sharp, Francesca Telese, Zhihua Jiang, Laura Saba, Xusheng Wang, Terence D Murphy, Abraham A Palmer, Anne E Kwitek, Melinda (Mindy) R Dwinell, Robert W Williams, Jun Z Li, Hao Chen
For over a decade, a large research community has relied on a flawed reference assembly of the genome ofRattus norvegicusknown as Rnor_6.0. The seventh assembly of the rat reference genome4mRatBN7.2, based on the inbred Brown Norway rat, corrects num
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::861340d72a1519c031afadb54233c22a
https://doi.org/10.1101/2023.04.13.536694
https://doi.org/10.1101/2023.04.13.536694
Publikováno v:
Hypertension (Dallas, Tex. : 1979)
The pathogenic links between elevated blood pressure and chronic kidney disease remain obscure. This article examines progress in population genetics and in animal models of hypertension and chronic kidney disease. It also provides a critique of the
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 6, Iss 10 (2017)
BackgroundWe have investigated serum levels of immunoreactive marinobufagenin (MBG) in 16‐ to 20‐week‐old spontaneously hypertensive rats (SHRs)‐A3 and in the normotensive Wistar‐Kyoto (WKY) rat strain in the absence of salt loading, and we
Externí odkaz:
https://doaj.org/article/d8fee34d3e3a4d2a9783cbbcbdee59e4
Autor:
Tristan V. de Jong, Hao Chen, Wesley A. Brashear, Kelli J. Kochan, Andrew E. Hillhouse, Yaming Zhu, Isha S. Dhande, Elizabeth A. Hudson, Mary H. Sumlut, Melissa L. Smith, Theodore S. Kalbfleisch, Peter A. Doris
Publikováno v:
Physiol Genomics
Rat genomic tools have been slower to emerge than for those of humans and mice and have remained less thorough and comprehensive. The arrival of a new and improved rat reference genome, mRatBN7.2, in late 2020 is a welcome event. This assembly, like
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf027dbe570f1ce6bac34858468c7008
https://europepmc.org/articles/PMC9236863/
https://europepmc.org/articles/PMC9236863/
Autor:
Peter A. Doris, M. John Hicks, Yaming Zhu, Scott E. Wenderfer, Aniket S. Joshi, Sterling C. Kneedler, Michael C. Braun, Isha S. Dhande
Publikováno v:
Physiol Genomics
The risk of cerebrovascular disease in stroke-prone spontaneously hypertensive rats (SHR-A3/SHRSP) arises from naturally occurring genetic variation. In the present study we show the involvement of SHR genetic variation that affects antibody formatio
Autor:
Isha S. Dhande, Peter A. Doris
Publikováno v:
Comprehensive Physiology
Chronic cardiovascular diseases are associated with inflammatory responses within the blood vessels and end organs. The origin of this inflammation has not been certain, and neither is its relationship to disease clear. There is a need to determine w