Zobrazeno 1 - 10
of 541
pro vyhledávání: '"Peter A Calabresi"'
Autor:
Andrew A Chen, Kelly Clark, Blake E Dewey, Anna DuVal, Nicole Pellegrini, Govind Nair, Youmna Jalkh, Samar Khalil, Jon Zurawski, Peter A Calabresi, Daniel S Reich, Rohit Bakshi, Haochang Shou, Russell T Shinohara, Alzheimer’s Disease Neuroimaging Initiative, and North American Imaging in Multiple Sclerosis Cooperative
Publikováno v:
PLoS Computational Biology, Vol 20, Iss 7, p e1012241 (2024)
Dimension reduction tools preserving similarity and graph structure such as t-SNE and UMAP can capture complex biological patterns in high-dimensional data. However, these tools typically are not designed to separate effects of interest from unwanted
Externí odkaz:
https://doaj.org/article/6dc81d154df04a90a16c0ae4b80ffc44
Publikováno v:
Neural Regeneration Research, Vol 18, Iss 12, Pp 2682-2684 (2023)
Externí odkaz:
https://doaj.org/article/3f01df1936544a98ac210712f166a2b2
Autor:
Em P Harrington, Riley B Catenacci, Matthew D Smith, Dongeun Heo, Cecilia E Miller, Keya R Meyers, Jenna Glatzer, Dwight E Bergles, Peter A Calabresi
Publikováno v:
eLife, Vol 12 (2023)
Oligodendrocytes and their progenitors upregulate MHC pathways in response to inflammation, but the frequency of this phenotypic change is unknown and the features of these immune oligodendroglia are poorly defined. We generated MHC class I and II tr
Externí odkaz:
https://doaj.org/article/6c2fcd46ec7947b482b027cb8b186788
Autor:
Ashley H Beecham, Lilyana Amezcua, Angel Chinea, Clara P Manrique, Lissette Gomez, Andrea Martinez, Gary W Beecham, Nikolaos A Patsopoulos, Tanuja Chitnis, Howard L Weiner, Philip L De Jager, Esteban G Burchard, Brett T Lund, Kathryn C Fitzgerald, Peter A Calabresi, Silvia R Delgado, Jorge R Oksenberg, Jacob L McCauley
Publikováno v:
PLoS ONE, Vol 17, Iss 12, p e0279132 (2022)
The Major Histocompatibility Complex (MHC) makes the largest genetic contribution to multiple sclerosis (MS) susceptibility, with 32 independent effects across the region explaining 20% of the heritability in European populations. Variation is high a
Externí odkaz:
https://doaj.org/article/2a71d7c0f97a4ee9840c19b2575059f4
Autor:
Jennifer Orthmann-Murphy, Cody L Call, Gian C Molina-Castro, Yu Chen Hsieh, Matthew N Rasband, Peter A Calabresi, Dwight E Bergles
Publikováno v:
eLife, Vol 9 (2020)
Destruction of oligodendrocytes and myelin sheaths in cortical gray matter profoundly alters neural activity and is associated with cognitive disability in multiple sclerosis (MS). Myelin can be restored by regenerating oligodendrocytes from resident
Externí odkaz:
https://doaj.org/article/3e88511fa920405d95c9ba12f7130d67
Autor:
Itzy E Morales Pantoja, Matthew D Smith, Labchan Rajbhandari, Linzhao Cheng, Yongxing Gao, Vasiliki Mahairaki, Arun Venkatesan, Peter A Calabresi, Kathryn C Fitzgerald, Katharine A Whartenby
Publikováno v:
PLoS ONE, Vol 15, Iss 6, p e0233980 (2020)
Multiple sclerosis (MS) is an inflammatory and demyelinating disease of the central nervous system (CNS) that results in variable severities of neurodegeneration. The understanding of MS has been limited by the inaccessibility of the affected cells a
Externí odkaz:
https://doaj.org/article/575b8464d15d450992578ce877033aa5
Publikováno v:
NeuroImage: Clinical, Vol 14, Iss C, Pp 490-498 (2017)
At least 85% of individuals with multiple sclerosis report walking dysfunction as their primary complaint. Walking and strength measures are common clinical measures to mark increasing disability or improvement with rehabilitation. Previous studies h
Externí odkaz:
https://doaj.org/article/5b533166f00c44bf93fdcfdb8a34322d
Autor:
Marjan Gharagozloo, Shaimaa Mahmoud, Camille Simard, Kenzo Yamamoto, Diwakar Bobbala, Subburaj Ilangumaran, Matthew D Smith, Albert Lamontagne, Samir Jarjoura, Jean-Bernard Denault, Véronique Blais, Louis Gendron, Carles Vilariño-Güell, A Dessa Sadovnick, Jenny P Ting, Peter A Calabresi, Abdelaziz Amrani, Denis Gris
Publikováno v:
PLoS Biology, Vol 17, Iss 9, p e3000451 (2019)
Nucleotide-binding, leucine-rich repeat containing X1 (NLRX1) is a mitochondria-located innate immune sensor that inhibits major pro-inflammatory pathways such as type I interferon and nuclear factor-κB signaling. We generated a novel, spontaneous,
Externí odkaz:
https://doaj.org/article/58ac34a8bf8e4f90ae99175810c13f3c
Autor:
Jaime Gonzalez Cardona, Matthew D Smith, Jingya Wang, Leslie Kirby, Jason T Schott, Todd Davidson, Jodi L Karnell, Katharine A Whartenby, Peter A Calabresi
Publikováno v:
PLoS ONE, Vol 14, Iss 9, p e0221747 (2019)
Multiple sclerosis (MS) is characterized by demyelinated lesions in the central nervous system. Destruction of myelin and secondary damage to axons and neurons leads to significant disability, particularly in people with progressive MS. Accumulating
Externí odkaz:
https://doaj.org/article/8c710515bfd64535a01b76fa9f35ddf6
Autor:
Ani Eloyan, Haochang Shou, Russell T Shinohara, Elizabeth M Sweeney, Mary Beth Nebel, Jennifer L Cuzzocreo, Peter A Calabresi, Daniel S Reich, Martin A Lindquist, Ciprian M Crainiceanu
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e107263 (2014)
Brain lesion localization in multiple sclerosis (MS) is thought to be associated with the type and severity of adverse health effects. However, several factors hinder statistical analyses of such associations using large MRI datasets: 1) spatial regi
Externí odkaz:
https://doaj.org/article/d315f552e7874357b682eabe9986236d