Ligand binding modulates the structural dynamics and activity of urokinase-type plasminogen activator: A possible mechanism of plasminogen activation.

Autor: Tobias Kromann-Hansen, Eva Louise Lange, Ida K Lund, Gunilla Høyer-Hansen, Peter A Andreasen, Elizabeth A Komives

Publikováno v: PLoS ONE, Vol 13, Iss 2, p e0192661 (2018)

The catalytic activity of trypsin-like serine proteases is in many cases regulated by conformational changes initiated by binding of physiological modulators to exosites located distantly from the active site. A trypsin-like serine protease of partic

Externí odkaz: https://doaj.org/article/e330651c2ec4416eab304ecffe07f697

Protein-binding RNA aptamers affect molecular interactions distantly from their binding sites.

Autor: Daniel M Dupont, Cathrine K Thuesen, Kenneth A Bøtkjær, Manja A Behrens, Karen Dam, Hans P Sørensen, Jan S Pedersen, Michael Ploug, Jan K Jensen, Peter A Andreasen

Publikováno v: PLoS ONE, Vol 10, Iss 3, p e0119207 (2015)

Nucleic acid aptamer selection is a powerful strategy for the development of regulatory agents for molecular intervention. Accordingly, aptamers have proven their diligence in the intervention with serine protease activities, which play important rol

Externí odkaz: https://doaj.org/article/71ab1028c4194de6a6c9ef9ae068d7e8

Origin and diversification of the plasminogen activation system among chordates

Autor: Andrés Chana-Muñoz, Agnieszka Jendroszek, Malene Sønnichsen, Tobias Wang, Michael Ploug, Jan K. Jensen, Peter A. Andreasen, Christian Bendixen, Frank Panitz

Publikováno v: BMC Evolutionary Biology, Vol 19, Iss 1, Pp 1-17 (2019)

Abstract Background The plasminogen (PLG) activation system is composed by a series of serine proteases, inhibitors and several binding proteins, which together control the temporal and spatial generation of the active serine protease plasmin. As thi

Externí odkaz: https://doaj.org/article/f88326412f624cdaaf8c846c9f0c414b

Plasminogen Activator Inhibitor-1 Is an Inhibitor of Factor VII-activating Protease in Patients with Acute Respiratory Distress Syndrome*

Autor: Philipp Markart, Peter A. Andreasen, Andreas Guenther, Klaus T. Preissner, Troels Wind, Rory E. Morty, Malgorzata Wygrecka, Sandip M. Kanse

Publikováno v: The Journal of Biological Chemistry

Factor VII-activating protease (FSAP) is a novel plasma-derived serine protease structurally homologous to tissue-type and urokinase-type plasminogen activators. We demonstrate that plasminogen activator inhibitor-1 (PAI-1), the predominant inhibitor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c67885e885a1349b4f3a5d2efaaa929
http://europepmc.org/articles/PMC8025756

Embelin ameliorated sepsis-induced disseminated intravascular coagulation intensities by simultaneously suppressing inflammation and thrombosis

Autor: Yu Wang, Mingdong Huang, Dong Wang, Yongshuai Yang, Wanjin Hong, Peng Xu, Peter A. Andreasen, Zhuo Chen, Valérie Proulle

Publikováno v: Wang, D, Yang, Y, Wang, Y, Proulle, V, Andreasen, P A, Hong, W, Chen, Z, Huang, M & Xu, P 2020, ' Embelin ameliorated sepsis-induced disseminated intravascular coagulation intensities by simultaneously suppressing inflammation and thrombosis ', Biomedicine & Pharmacotherapy, vol. 130, 110528 . https://doi.org/10.1016/j.biopha.2020.110528
Biomedicine & Pharmacotherapy, Vol 130, Iss, Pp 110528-(2020)

Disseminated intravascular coagulation (DIC), an acute syndrome of systemic thrombus formation in microvasculatures throughout the body, can be induced by severe infections, e.g. sepsis. Anticoagulants are clinically used to alleviate the intensities

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f06eaa1ecb4b918018b0a393d873ba0
https://pure.au.dk/portal/da/publications/embelin-ameliorated-sepsisinduced-disseminated-intravascular-coagulation-intensities-by-simultaneously-suppressing-inflammation-and-thrombosis(1fbcfaba-bcd6-4c23-b5ac-d1fc40990429).html