Zobrazeno 1 - 10
of 222
pro vyhledávání: '"Peter A, van Veelen"'
Autor:
Isabella Senini, Sara Tengattini, Francesca Rinaldi, Gabriella Massolini, Christoph Gstöttner, Dietmar Reusch, Marcello Donini, Carla Marusic, Peter A. van Veelen, Elena Domínguez-Vega, Manfred Wuhrer, Caterina Temporini, Simone Nicolardi
Publikováno v:
Communications Chemistry, Vol 7, Iss 1, Pp 1-10 (2024)
Abstract Monoclonal antibody (mAb) glycoengineering has the potential to improve the efficacy of biopharmaceuticals by fine-tuning specific biological properties. Glycosylation analysis is key to monitoring the glycoengineering process. Various mass
Externí odkaz:
https://doaj.org/article/1b14d36527f6452a9d61a7e221f66757
Autor:
Hans Gelderblom, Peter A van Veelen, Noel de Miranda, Arnoud H de Ru, Judith V M G Bovée, Dina Ruano, Marieke Ijsselsteijn, Manon van der Ploeg, Siddh van Oost, Debora M Meijer, Jessica P Roelands, I H Briaire-de Bruijn, B E van den Akker, A B Kruisselbrink, P M Wijers-Koster, S W Lam, R T N Tjokrodirijo, M A J van de Sande, M L Kuijjer
Publikováno v:
BMJ Oncology, Vol 3, Iss 1 (2024)
Objective Osteosarcoma is the most common primary bone sarcoma. About 50% of patients develop metastatic disease and their 5-year survival lingers at around 20%–30%. T cell checkpoint blockade immunotherapies have revolutionised cancer treatment in
Externí odkaz:
https://doaj.org/article/f7ac0bc0200f4326baebbac92a871b2d
Autor:
Daniel Salas-Lloret, Néstor García-Rodríguez, Emily Soto-Hidalgo, Lourdes González-Vinceiro, Carmen Espejo-Serrano, Lisanne Giebel, María Luisa Mateos-Martín, Arnoud H. de Ru, Peter A. van Veelen, Pablo Huertas, Alfred C. O. Vertegaal, Román González-Prieto
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Deficiencies in the BRCA1 tumor suppressor gene are the main cause of hereditary breast and ovarian cancer. BRCA1 is involved in the Homologous Recombination DNA repair pathway and, together with BARD1, forms a heterodimer with ubiquitin E3
Externí odkaz:
https://doaj.org/article/3e5701fc02264129ac1bfa7414d7e198
Autor:
E. Onur Karakaslar, Jeppe F. Severens, Elena Sánchez-López, Peter A. van Veelen, Mihaela Zlei, Jacques J. M. van Dongen, Annemarie M. Otte, Constantijn J. M. Halkes, Peter van Balen, Hendrik Veelken, Marcel J. T. Reinders, Marieke Griffioen, Erik B. van den Akker
Publikováno v:
npj Precision Oncology, Vol 8, Iss 1, Pp 1-11 (2024)
Abstract The diagnostic spectrum for AML patients is increasingly based on genetic abnormalities due to their prognostic and predictive value. However, information on the AML blast phenotype regarding their maturational arrest has started to regain i
Externí odkaz:
https://doaj.org/article/21d4317eb7704a259707b43c5a1bffc6
Acetylated bacterial proteins as potent antigens inducing an anti-modified protein antibody response
Autor:
Tom W J Huizinga, Diane van der Woude, René E M Toes, Mikhail Volkov, Peter A van Veelen, Joanneke C Kwekkeboom, Karin A J van Schie, Arieke S B Kampstra, Anouk G van Mourik, Arnoud de Ru
Publikováno v:
RMD Open, Vol 10, Iss 3 (2024)
Objective Gut-residing bacteria, such as Escherichia coli, can acetylate their proteome under conditions of amine starvation. It is postulated that the (gut) microbiome is involved in the breach of immune tolerance to modified self-proteins leading t
Externí odkaz:
https://doaj.org/article/9c5b5041e28d4dc9a561bd66be48dfdc
Autor:
Wei Wang, Tao Zhang, Jan Nouta, Peter A. van Veelen, Noortje de Haan, Theo M. de Reijke, Manfred Wuhrer, Guinevere S.M. Lageveen-Kammeijer
Publikováno v:
Engineering, Vol 26, Iss , Pp 119-131 (2023)
Ketodeoxynononic acid (Kdn) is a rather uncommon class of sialic acid in mammals. However, associations have been found between elevated concentrations of free or conjugated Kdn in relation to human cancer progression. Hitherto, there has been a lack
Externí odkaz:
https://doaj.org/article/a218f8e8bafb472a93b2565b68e59d0e
Autor:
Leoni Abendstein, Douwe J. Dijkstra, Rayman T. N. Tjokrodirijo, Peter A. van Veelen, Leendert A. Trouw, Paul J. Hensbergen, Thomas H. Sharp
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract IgG3 is unique among the IgG subclasses due to its extended hinge, allotypic diversity and enhanced effector functions, including highly efficient pathogen neutralisation and complement activation. It is also underrepresented as an immunothe
Externí odkaz:
https://doaj.org/article/fcdc499f722c4bd9aa23f3e4ee0d4314
Autor:
Tom Cremer, Hanneke Hoelen, Michael L van de Weijer, George M Janssen, Ana I Costa, Peter A van Veelen, Robert Jan Lebbink, Emmanuel J H J Wiertz
Publikováno v:
PLoS ONE, Vol 19, Iss 5, p e0287877 (2024)
Type 1 diabetes (T1D) is characterized by HLA class I-mediated presentation of autoantigens on the surface of pancreatic β-cells. Recognition of these autoantigens by CD8+ T cells results in the destruction of pancreatic β-cells and, consequently,
Externí odkaz:
https://doaj.org/article/e120816276044d81a6197f415591e794
Autor:
Marije A.J. de Rooij, Dennis F.G. Remst, Dirk M. van der Steen, Anne K. Wouters, Renate S. Hagedoorn, Michel G.D. Kester, Miranda H. Meeuwsen, Tassilo L.A. Wachsmann, Arnoud H. de Ru, Peter A. van Veelen, Els M.E. Verdegaal, J.H. Frederik Falkenburg, Mirjam H.M. Heemskerk
Publikováno v:
Molecular Therapy: Oncolytics, Vol 31, Iss , Pp 100738- (2023)
Externí odkaz:
https://doaj.org/article/7c73b9078d954e7dbfd0dc7bad6960f5
Autor:
Bert van de Kooij, Evert de Vries, Rogier W. Rooswinkel, George M. C. Janssen, Frédérique K. Kok, Peter A. van Veelen, Jannie Borst
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract The majority of proteins in mammalian cells are modified by covalent attachment of an acetyl-group to the N-terminus (Nt-acetylation). Paradoxically, Nt-acetylation has been suggested to inhibit as well as to promote substrate degradation. C
Externí odkaz:
https://doaj.org/article/304e7d80f3b147c9966b6c141fbfb7bc