Výsledky vyhledávání - "Peter A, Soden"

A randomized study of the safety and pharmacokinetics of GSK3358699, a mononuclear myeloid‐targeted bromodomain and extra‐terminal domain inhibitor

Autor: Helen Carnaghan, Joanne Bal, Rab K. Prinjha, Jackie C. Bloomer, Jack A. Brown, Peter Ernest Soden, Palwinder K. Mander, Sarah J Hopkins, João Joaquim Oliveira, Lars Erwig, William A. Fahy, Yi Cui, Shruti Daga, Bill Davis, Monica Simeoni, Disala Fernando, Peter Williams, Gabriel K. Wong, Edward Banham-Hall

Publikováno v: British Journal of Clinical Pharmacology. 88:2140-2155

GSK3358699 is a mononuclear myeloid-targeted bromodomain and extra-terminal domain (BET) family inhibitor which demonstrates immunomodulatory effects in vitro. This phase 1, randomized, first-in-human study evaluated the safety, pharmacokinetics, and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00f34b1eba5965c28f508e7e1d4d7679
https://doi.org/10.1111/bcp.15137

Zobrazit plný text záznamu

The impact of neighborhood social disadvantage on abdominal aortic aneurysm severity and management

Autor: Lucas Mota, Christina L. Marcaccio, Priya B. Patel, Peter A. Soden, Carla C. Moreira, Lars Stangenberg, Kakra Hughes, Marc L. Schermerhorn

Publikováno v: Journal of vascular surgery.

Recent studies have highlighted socioeconomic disparities in the severity and management of abdominal aortic aneurysm (AAA) disease. However, these studies focus on individual measures of social disadvantage such as income and insurance status. The a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e4dfc2d957a0978a25624951e6d6a5f
https://pubmed.ncbi.nlm.nih.gov/36347436

Zobrazit plný text záznamu

Aspartate transaminase to platelet ratio index and Model for End-Stage Liver Disease scores are associated with morbidity and mortality after endovascular aneurysm repair among patients with liver dysfunction

Autor: Nicholas J. Swerdlow, Amy Evenson, Sara L. Zettervall, Peter A. Soden, Marc L. Schermerhorn, Kirsten Dansey

Publikováno v: Journal of Vascular Surgery. 72:904-909

Background Liver cirrhosis dramatically increases morbidity and mortality after open surgical procedures and is often a contraindication to open repair of abdominal aortic aneurysms. However, limited data have evaluated the effect of liver disease on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b0ca00b0d914b0733e39efc9710a4c8b
https://doi.org/10.1016/j.jvs.2019.10.101

Zobrazit plný text záznamu

GSK789: A Selective Inhibitor of the First Bromodomains (BD1) of the Bromo and Extra Terminal Domain (BET) Proteins

Autor: Peter Ernest Soden, Massimo Petretich, Robert J. Watson, Laurie J. Gordon, Chun-wa Chung, Paola Grandi, Alex Phillipou, Paul Bamborough, Emmanuel Hubert Demont, Rab K. Prinjha, Inmaculada Rioja, Thilo Werner, Robert E. Davis, Heather A. Barnett

Publikováno v: Journal of Medicinal Chemistry. 63:9045-9069

Pan-bromodomain and extra terminal (BET) inhibitors interact equipotently with all eight bromodomains of the BET family of proteins. They have shown profound efficacy in vitro and in vivo in oncology and immunomodulatory models, and a number of them

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3697424bf0dce94f0fb982a9f330e0e
https://doi.org/10.1021/acs.jmedchem.0c00614

Zobrazit plný text záznamu

Statin therapy is associated with improved perioperative outcomes and long-term mortality following carotid revascularization in the Vascular Quality Initiative

Autor: Aderike C, Anjorin, Christina L, Marcaccio, Vinamr, Rastogi, Priya B, Patel, Parveen K, Garg, Peter A, Soden, John C, McCallum, Marc L, Schermerhorn

Publikováno v: Journal of Vascular Surgery. 77:158-169.e8

Statin therapy is the standard of care for patients with carotid artery stenosis given its proven cardiovascular benefits. However, the impact of statin therapy on outcomes in patients undergoing carotid revascularization in the Vascular Quality Init

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::460de9434dcbeff9042abc2ac77e334c
https://doi.org/10.1016/j.jvs.2022.08.019

Zobrazit plný text záznamu

Disparities in 5-year outcomes and imaging surveillance following elective endovascular repair of abdominal aortic aneurysm by sex, race, and ethnicity

Autor: Christina L. Marcaccio, Priya B. Patel, Livia E.V.M. de Guerre, Jacqueline E. Wade, Vinamr Rastogi, Aderike Anjorin, Peter A. Soden, Kakra Hughes, Salvatore T. Scali, Art Sedrakyan, Marc L. Schermerhorn

Publikováno v: Journal of Vascular Surgery, 76(5), 1205-1215.e4. Mosby Inc.

Objectives: Sex, racial, and ethnic disparities in postoperative outcomes following abdominal aortic aneurysm repair have been described, but differences in long-term outcomes are poorly understood. Our aim was to identify differences in 5-year outco

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4118d926b645037bffc63901a85f632d
https://doi.org/10.1016/j.jvs.2022.03.886

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání