Zobrazeno 1 - 10
of 145
pro vyhledávání: '"Peter Scheurich"'
Publikováno v:
PLoS ONE, Vol 13, Iss 6, p e0198203 (2018)
Dysregulation of the mitochondrial signaling pathway of apoptosis induction represents a major hurdle in tumor therapy. The objective of the presented work was to investigate the role of the intrinsic (mitochondrial) apoptotic pathway in the non-smal
Externí odkaz:
https://doaj.org/article/9e232127ea1d4ef3932132940bc1d1b5
Autor:
Florian Kälble, Janine Damaske, Danijela Heide, Iris Arnold, Fabian Richter, Olaf Maier, Ulrich Eisel, Peter Scheurich, Klaus Pfizenmaier, Martin Zeier, Vedat Schwenger, Julia Ranzinger
Publikováno v:
PLoS ONE, Vol 11, Iss 10, p e0163314 (2016)
Chronic inflammatory conditions during peritoneal dialysis (PD)-treatment lead to the impairment of peritoneal tissue integrity. The resulting structural and functional reorganization of the peritoneal membrane diminishes ultrafiltration rate and the
Externí odkaz:
https://doaj.org/article/4e33af30d62344f98179baa89837025b
Cell cycle progression and transmitotic apoptosis resistance promote escape from extrinsic apoptosis
Autor:
Peter Scheurich, Frank Allgöwer, Daniela Stöhr, Markus Rehm, Isabel Heinrich, Karsten Kuritz, Nadine Pollak, Aline Lindner, Lorena Decker, Jacques S Fritze, Jannis Stadager, Dirke Imig, Stephan A. Eisler
Publikováno v:
Journal of Cell Science. 134
Extrinsic apoptosis relies on TNF-family receptor activation by immune cells or receptor-activating drugs. Here, we monitored cell cycle progression at a resolution of minutes to relate apoptosis kinetics and cell-to-cell heterogeneities in death dec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d58a0d8bb5223055bc6ed248d9a2252
https://doi.org/10.1242/jcs.258966
https://doi.org/10.1242/jcs.258966
Autor:
Nadine Pollak, Jacques S Fritze, Peter Scheurich, Karsten Kuritz, Heinrich I, Daniela Stöhr, Stadager J, Frank Allgöwer, Morrison (Rehm) M, Stephan A. Eisler, Lindner A, Dirke Imig
Extrinsic apoptosis relies on TNF-family receptor activation by immune cells or receptor-activating biologics. Here, we monitored cell cycle progression at minutes resolution to relate apoptosis kinetics and cell-to-cell heterogeneities in death deci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c10c31887ebdd075fce8b628a8c953b7
https://doi.org/10.1101/2021.02.26.433034
https://doi.org/10.1101/2021.02.26.433034
Autor:
Fabian Richter, Timo Liebig, Eric Guenzi, Andreas Herrmann, Peter Scheurich, Klaus Pfizenmaier, Roland E Kontermann
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e72156 (2013)
BACKGROUND: Selective inhibition of TNFR1 signaling holds the potential to greatly reduce the pro-inflammatory activity of TNF, while leaving TNFR2 untouched, thus allowing for cell survival and tissue homeostasis. ATROSAB is a humanized antagonistic
Externí odkaz:
https://doaj.org/article/4f53bc5bdaa4432bb1434b52d5f6a3fa
Autor:
Kai Cao, Peter Scheurich, Roland E. Kontermann, Tobias B. Beigl, Thomas E. Mürdter, Cathrin Hagenlocher, Alexandra Mack, Daniela Simone Maichl, Stephen W.G. Tait, Daniela Stöhr, Markus Rehm, Beate Budai, Jens O Schmid, Gavin Fullstone, Nadine Pollak
Publikováno v:
Cell Death and Differentiation
The influence of 3D microenvironments on apoptosis susceptibility remains poorly understood. Here, we studied the susceptibility of cancer cell spheroids, grown to the size of micrometastases, to tumor necrosis factor-related apoptosis-inducing ligan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4746167a42442d4aa67874014f1dcaf8
https://eprints.gla.ac.uk/219472/1/219472.pdf
https://eprints.gla.ac.uk/219472/1/219472.pdf
Autor:
Simon Neumann, Tobias Bidon, Marcus Branschädel, Anja Krippner-Heidenreich, Peter Scheurich, Malgorzata Doszczak
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e42526 (2012)
TNF-related apoptosis-inducing ligand (TRAIL) is a member of the tumor necrosis factor (TNF) ligand family that exerts its apoptotic activity in human cells by binding to two transmembrane receptors, TRAILR1 and TRAILR2. In cells co-expressing both r
Externí odkaz:
https://doaj.org/article/b4efd875d417403ab0654027ab7a4e69
Autor:
Oliver Seifert, Fabian Richter, Roland E. Kontermann, Andreas Herrmann, Peter Scheurich, Kirstin A. Zettlitz, Klaus Pfizenmaier
Publikováno v:
mAbs. 11:166-177
Selective inhibition of tumor necrosis factor (TNF) signaling through the proinflammatory axis of TNF-receptor 1 (TNFR1) while leaving pro-survival and regeneration-promoting signals via TNFR2 unaffected is a promising strategy to circumvent limitati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dfba25efac48c7cad4e0a937080ec9a
https://doi.org/10.1080/19420862.2018.1524664
https://doi.org/10.1080/19420862.2018.1524664
Autor:
Michael A Dengler, Annette M Staiger, Matthias Gutekunst, Ute Hofmann, Malgorzata Doszczak, Peter Scheurich, Matthias Schwab, Walter E Aulitzky, Heiko van der Kuip
Publikováno v:
PLoS ONE, Vol 6, Iss 9, p e25139 (2011)
In response to deregulated oncogene activation, mammalian cells activate disposal programs such as programmed cell death. To investigate the mechanisms behind this oncogenic stress response we used Bcr-Abl over-expressing cells cultivated in presence
Externí odkaz:
https://doaj.org/article/30003634020a4e90af9989fc1b2c9212
Autor:
Julia Ranzinger, Amin Rustom, Marcus Abel, Julia Leyh, Lars Kihm, Margarete Witkowski, Peter Scheurich, Martin Zeier, Vedat Schwenger
Publikováno v:
PLoS ONE, Vol 6, Iss 12, p e29537 (2011)
A well-known role of human peritoneal mesothelial cells (HPMCs), the resident cells of the peritoneal cavity, is the generation of an immune response during peritonitis by activation of T-cells via antigen presentation. Recent findings have shown tha
Externí odkaz:
https://doaj.org/article/9ed6cb64585944528d9a56cef668a42e