Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Peter Reinemer"'
Autor:
Harald Mückter, Robin Lüling, Markus Siegert, Harald John, Horst Thiermann, Tanja Popp, Peter Reinemer, Dirk Steinritz, Thomas Gudermann
Publikováno v:
Archives of Toxicology
Creatine kinase (CK) catalyzes the formation of phosphocreatine from adenosine triphosphate (ATP) and creatine. The highly reactive free cysteine residue in the active site of the enzyme (Cys283) is considered essential for the enzymatic activity. In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13e9ec3b697a5c292bc7a961938434fe
https://pubmed.ncbi.nlm.nih.gov/34396457
https://pubmed.ncbi.nlm.nih.gov/34396457
Autor:
Stefan Steinbacher, Michel Weïwer, Surya A. Reis, Peter Müller, Peter Reinemer, Adrian Schomburg, Jennifer P. Gale, Daniel M. Fass, Stephen J. Haggarty, Krista M. Hennig, Edward B. Holson, Yan-Ling Zhang, Méryl Thomas, Florence F. Wagner, Stewart L. Fisher, Arthur J. Campbell, Wen-Ning Zhao, Martin R. Jefson
Publikováno v:
Bioorganic & Medicinal Chemistry. 24:4008-4015
The structure-activity and structure-kinetic relationships of a series of novel and selective ortho-aminoanilide inhibitors of histone deacetylases (HDACs) 1 and 2 are described. Different kinetic and thermodynamic selectivity profiles were obtained
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63045fca9b4f066148969149fb209604
https://doi.org/10.1016/j.bmc.2016.06.040
https://doi.org/10.1016/j.bmc.2016.06.040
Autor:
F. X. Gomis-Rüth, Walter Stöcker, Ulrich Baumann, Frank Grams, Wolfram Bode, David B. McKay, Peter Reinemer
Publikováno v:
Protein Science. 4:823-840
The three-dimensional structures of the zinc endopeptidases human neutrophil collagenase, adamalysin II from rattle snake venom, alkaline proteinase from Pseudomonas aeruginosa, and astacin from crayfish are topologically similar, with respect to a f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d297c50152638668990b295c3a5dd46d
https://doi.org/10.1002/pro.5560040502
https://doi.org/10.1002/pro.5560040502
Autor:
Wolfram Bode, Peter Reinemer, Luis Moroder, Sergio A. Cadamuro, Peter Goettig, Holger Steuber, Marion G. Götz, Michael Willem, Christian Renner, Tanja Kohler, Anja Jestel, Alessandra Barazza
Publikováno v:
ChemBioChem. 8:2078-2091
Minimal sequence requirements for binding of substrate-derived statine peptides to the aspartyl enzyme were established on the basis of the X-ray cocrystal structure of the hydroxyethylene-octapeptide OM00-3 in complexation with BACE-1. With this inf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b8d2185df743b60e3862174f2a7ac8b
https://doi.org/10.1002/cbic.200700383
https://doi.org/10.1002/cbic.200700383
Autor:
Marc Stadler, Kevin B. Bacon, Peter Reinemer, Hartwig Müller, Florian Gantner, Hans-Volker Tichy, Jens Bitzer, Jordi Benet-Buchholz, Anke Mayer-Bartschmid
Publikováno v:
Journal of Natural Products. 70:246-252
The cinnabaramides A-G (1-7) were isolated from a terrestrial strain of Streptomyces as potent and selective inhibitors of the human 20S proteasome. Their chemical and biological properties resemble those of salinosporamide A, a recently identified l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c62f2fb500cc350fa8fe2563d20e326b
https://doi.org/10.1021/np060162u
https://doi.org/10.1021/np060162u
Publikováno v:
PROTEOMICS. 6:2947-2958
Authentic biomarkers, distilling the essence of a complex, functionally significant process in a mammalian system into a precise, physicochemical measurement have been implicated as a tool of increasing importance for drug discovery and development.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fce93488415c59578212acf5c3359f84
https://doi.org/10.1002/pmic.200500659
https://doi.org/10.1002/pmic.200500659
Publikováno v:
Journal of Molecular Biology. 358:1328-1340
DNA topoisomerases are a family of enzymes altering the topology of DNA by concerted breakage and rejoining of the phosphodiester backbone of DNA. Bacterial and archeal type IA topoisomerases, including topoisomerase I, topoisomerase III, and reverse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24aa960360ffc0304817781359e621b4
https://doi.org/10.1016/j.jmb.2006.03.012
https://doi.org/10.1016/j.jmb.2006.03.012
Autor:
Alexander Straub, Thomas Lampe, Josef Pernerstorfer, Jens Pohlmann, Karl-Heinz Schlemmer, Elisabeth Perzborn, Susanne Roehrig, Peter Reinemer
Publikováno v:
Journal of Medicinal Chemistry. 48:5900-5908
Despite recent progress in antithrombotic therapy, there is still an unmet medical need for safe and orally available anticoagulants. The coagulation enzyme Factor Xa (FXa) is a particularly promising target, and recent efforts in this field have foc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21827e36874c86f15973cb5e7f73d10d
https://doi.org/10.1021/jm050101d
https://doi.org/10.1021/jm050101d
Publikováno v:
Angewandte Chemie. 39:2834-2846
Organic synthesis of hormone derivatives is an established route to yield pharmacologically active agents. Until recently this has only been feasible for small organic compounds, but nowadays it is also possible to produce antagonists for larger prot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::75cc0bcac5d0f22d454f46c81c866e24
https://doi.org/10.1002/1521-3773(20000818)39:16<2834::aid-anie2834>3.0.co
https://doi.org/10.1002/1521-3773(20000818)39:16<2834::aid-anie2834>3.0.co
Publikováno v:
Angewandte Chemie. 112:2954-2966
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9b5c75112a890685f323d787d23431c8
https://doi.org/10.1002/1521-3757(20000818)112:16<2954::aid-ange2954>3.0.co
https://doi.org/10.1002/1521-3757(20000818)112:16<2954::aid-ange2954>3.0.co