Excessive dietary lipid intake provokes an acquired form of lysosomal lipid storage disease in the kidney

Autor: Johannes P. C. Vissers, Martin H. de Borst, Gerjan Navis, Jan Aten, Eric J. Steenbergen, Bettina Jung, Andrea Ballabio, Loes M. Butter, Jaklien C. Leemans, Sandrine Florquin, Nike Claessen, Johannes M. F. G. Aerts, Lotte Kors, Lee A. Gethings, Elena Rampanelli, Alessia Calcagni, Stephan J. L. Bakker, Peter Ochodnicky, Marius A. van den Bergh Weerman, Gerd Schmitz, Dave Speijer, Gerhard Liebisch

Publikováno v: Journal of Pathology

Obesity and dyslipidaemia are features of the metabolic syndrome and risk factors for chronic kidney disease. The cellular mechanisms connecting metabolic syndrome with chronic kidney disease onset and progression remain largely unclear. We show that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d1a03b117b030fc71da98f8414acd525
https://doi.org/10.1002/path.5150

β-Cyclodextrin counteracts obesity in Western diet-fed mice but elicits a nephrotoxic effect

Autor: Loes M. Butter, Marius A. van den Bergh Weerman, Angelique M. L. Scantlebery, Peter Ochodnicky, Nike Claessen, Sandrine Florquin, Joris J. T. H. Roelofs, Jaklien C. Leemans, Chaima El Boumashouli, Gwen J. Teske, Elena Rampanelli, Lotte Kors

Publikováno v: Scientific reports, 9(1):17633. Nature Publishing Group
Scientific Reports, Vol 9, Iss 1, Pp 1-14 (2019)
Scientific Reports

Obesity has become a worldwide health crisis and is associated with a plethora of comorbidities. The multi-organ effects of obesity have been linked to ectopic lipid accumulation. Thus, there is an urgent need to tackle the obesity crisis by developi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c6e40e745f96d29af645c64693b2b3f
https://pure.amc.nl/en/publications/cyclodextrin-counteracts-obesity-in-western-dietfed-mice-but-elicits-a-nephrotoxic-effect(4beae7f2-a90e-48af-9709-f31ad0379618).html

Metabolic injury-induced NLRP3 inflammasome activation dampens phospholipid degradation

Autor: Gerd Schmitz, Nike Claessen, Sandrine Florquin, Elena Rampanelli, Evelyn Orsó, Peter Ochodnicky, Jaklien C. Leemans, Marius A. van den Bergh Weerman, Loes M. Butter, Pieter J. Bakker, Gerhard Liebisch

Publikováno v: Scientific reports, 7(1). Nature Publishing Group
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Scientific Reports

The collateral effects of obesity/metabolic syndrome include inflammation and renal function decline. As renal disease in obesity can occur independently of hypertension and diabetes, other yet undefined causal pathological pathways must be present.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::009a656ea7ace8ca02647f8ad3980657
https://doi.org/10.1038/s41598-017-01994-9

Pioglitazone, a PPARγ agonist, provides comparable protection to angiotensin converting enzyme inhibitor ramipril against adriamycin nephropathy in rat

Autor: Jan Klimas, Jan Kyselovic, Hana Cernecka, Peter Krenek, Robert H. Henning, Richard P. E. van Dokkum, Lucia Mesarosova, Peter Ochodnicky, Maaike Goris

Publikováno v: European journal of pharmacology, 730, 51-60. Elsevier
European Journal of Pharmacology, 730, 51-60. ELSEVIER SCIENCE BV

Peroxisome proliferator-activated receptor γ (PPARγ) agonists have been shown to ameliorate diabetic nephropathy, but much less are known about their effects in non-diabetic nephropathies. In the present study, metabolic parameters, blood pressure,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abdec833a7a03ca0f0b95c49f46aaf77
https://doi.org/10.1016/j.ejphar.2014.02.023

Renal endothelial function is associated with the anti-proteinuric effect of ACE inhibition in 5/6 nephrectomized rats

Autor: Dick de Zeeuw, Robert H. Henning, Peter Vavrinec, Leo E. Deelman, Hendrik Buikema, Peter Ochodnicky, Simone Vettoretti

Publikováno v: American journal of physiology-Renal physiology, 310(10), F1047-F1053. AMER PHYSIOLOGICAL SOC
American journal of physiology. Renal physiology, 310(10), F1047-F1053. American Physiological Society

In healthy rats, the physiological variation of baseline endothelial function of intrarenal arteries correlates with the severity of renal damage in response to a subsequent specific renal injury. However, whether such a variation in endothelial func

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72883fab6fd705ac613f9d82510b731e
https://research.rug.nl/en/publications/598dacb4-6127-4fe8-b8a1-dbde5d64b8e3