Zobrazeno 1 - 10
of 157
pro vyhledávání: '"Peter Mundel"'
Autor:
Amy D. Westerling-Bui, Eva Maria Fast, Thomas W. Soare, Srinivasan Venkatachalan, Michael DeRan, Alyssa B. Fanelli, Sergii Kyrychenko, Hien Hoang, Grinal M. Corriea, Wei Zhang, Maolin Yu, Matthew Daniels, Goran Malojcic, Xin-Ru Pan-Zhou, Mark W. Ledeboer, Jean-Christophe Harmange, Maheswarareddy Emani, Thomas T. Tibbitts, John F. Reilly, Peter Mundel
Publikováno v:
Science Advances. 8
Pharmacodynamic (PD) studies are an essential component of preclinical drug discovery. Current approaches for PD studies, including the analysis of novel kidney disease targeting therapeutic agents, are limited to animal models with unclear translata
Autor:
Wei Zhang, Michael DeRan, Goran Malojčić, Xin-Ru Pan-Zhou, Maheswarareddy Emani, Jean-Christophe Harmange, Alyssa B. Fanelli, Hien Hoang, Peter Mundel, John F. Reilly, Mark W. Ledeboer, Amy Westerling-Bui, Maolin Yu, Srinivasan Venkatachalan, Sergii Kyrychenko, Thomas T. Tibbitts, Eva Maria Fast, Thomas W. Soare, Grinal M. Corriea
Publikováno v:
Nephrology Dialysis Transplantation. 35
Background and Aims A major challenge in drug discovery is gaining confidence in the human relevance of pre-clinical animal studies. While human iPSC-derived organoids offer exciting opportunities to address this, concerns about applicability and sca
Autor:
Peter Mundel
Summary: This protocol describes the procedure for perfusion of mice prior to organ or tissue harvesting . Diabetic Complications
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8a7196c91a2066eb8fcab059888b4bd6
https://doi.org/10.17504/protocols.io.8ezhtf6
https://doi.org/10.17504/protocols.io.8ezhtf6
Autor:
Peter Mundel
Publikováno v:
Seminars in Nephrology. 36:459-462
Autor:
Christopher E. Pedigo, Ying Wang, Heino Velazquez, Shuta Ishibe, Hossam Hassan, Zhen Wang, Peter Mundel, Koichi Yamamoto, Marwin Groener, Wei Li, Keita Soda, Jee-Won Shin, Kazunori Inoue, Xuefei Tian, Elizabeth Cross
Publikováno v:
J Am Soc Nephrol
Background Inhibition of the renin-angiotensin system remains a cornerstone in reducing proteinuria and progression of kidney failure, effects believed to be the result of reduction in BP and glomerular hyperfiltration. However, studies have yielded
Autor:
Eugene P. Rhee, Abbe R. Clark, Eric Hesse, Astrid Weins, Harald Jüppner, Mary L. Bouxsein, Anna Greka, Marta Christov, Niels Galjart, Hiroaki Saito, Peter Mundel, Braden Corbin, Ji Yong Jung, Samy Hakroush, Daniel J. Brooks
Publikováno v:
JCI Insight, Vol 3, Iss 4 (2018)
JCI insight, 3(4):e95091. The American Society for Clinical Investigation
JCI insight, 3(4):e95091. The American Society for Clinical Investigation
Progressive chronic kidney diseases (CKDs) are on the rise worldwide. However, the sequence of events resulting in CKD progression remain poorly understood. Animal models of CKD exploring these issues are confounded by systemic toxicities or surgical
Autor:
Monica Schwartzman, Karl Tryggvason, Lisette Casagrande, John M. Basgen, Kristin Meliambro, Astrid Weins, Jaakko Patrakka, Peter Mundel, Susanne B. Nicholas, Ilse Daehn, R K Gupta, Andrey S. Shaw, Kirk N. Campbell, David Lessman, John Cijiang He, Jenny Wong
Publikováno v:
The American Journal of Pathology. 185:2143-2157
Podocyte loss is central to the progression of proteinuric kidney diseases leading to end-stage kidney disease (ESKD), requiring renal replacement therapy, such as dialysis. Despite modern tools and techniques, the 5-year mortality of some patients r
Autor:
Peter Mundel
Publikováno v:
Pflugers Archiv : European journal of physiology. 469(7-8)
In this review, I describe a 30-year journey in the quest for precision medicines for patients with kidney diseases. In 1987, when I started my reseach career, most scientists studying glomerular disease biology were focused on mesangial cells. The c
Autor:
Michael R. Burgess, Charles L. Sawyers, John Wongvipat, Minna D. Balbas, Rajmohan Murali, Astrid Weins, Peter Mundel, Brian J. Skaggs
Publikováno v:
Proceedings of the National Academy of Sciences. 111:14876-14881
MAGUK Inverted 2 (MAGI-2) is a PTEN-interacting scaffold protein implicated in cancer on the basis of rare, recurrent genomic translocations and deletions in various tumors. In the renal glomerulus, MAGI-2 is exclusively expressed in podocytes, speci
Autor:
Mehmet M. Altintas, Chih Chuan Yu, Domenico Corradi, Jer Ming Chang, Anna Solini, Giovanna Finzi, Melissa Chin, Monika A. Niewczas, Moufida Ben Nasr, Paolo Fiorina, Sara Tezza, Maria Pia Rastaldi, Deborah Mattinzoli, Marcus G. Pezzolesi, Andrea Vergani, Peter Mundel, Andrzej S. Krolewski, Stefano La Rosa, Francesca D'Addio, Masami Ikehata, Roberto Bassi, Lisa Buvall, Mohamed H. Sayegh, Jochen Reiser, Flavio Vincenti, Valérie Schumacher
Publikováno v:
Journal of the American Society of Nephrology. 25:1415-1429
Podocyte injury and resulting albuminuria are hallmarks of diabetic nephropathy, but targeted therapies to halt or prevent these complications are currently not available. Here, we show that the immune-related molecule B7-1/CD80 is a critical mediato