An improved procedure for the synthesis of fourteen 4-OH and 3-MeO-4OH metabolites of fentanyl analogues from two intermediates on multi-gram scale

Autor: Tobias Rautio, Jonathan Thornell, Henrik Gréen, Peter Konradsson, Johan Dahlén, Xiongyu Wu

Publikováno v: Synthetic Communications. 52:392-401

Fentanyl analogues have appeared on the recreational drug market during the last ten years and caused many fatal overdoses around the world due to their high potencies. Their metabolites are of great interest for toxicology, metabolism and identifica

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee0b2bbf199c75eebd6cb57056ab36e6
https://doi.org/10.1080/00397911.2022.2026396

Transthyretin Binding Mode Dichotomy of Fluorescent trans-Stilbene Ligands

Autor: Afshan Begum, Jun Zhang, Dean Derbyshire, Xiongyu Wu, Peter Konradsson, Per Hammarström, Eleonore von Castelmur

The orientations of ligands bound to the transthyretin (TTR) thyroxine (T4) binding site are difficult to predict. Conflicting binding modes of resveratrol have been reported. We previously reported two resveratrol based trans-stilbene fluorescent li

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7447e05791def2b1a137281af28065b5
http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-192506

A review of nine years of NPS synthesis research projects supported by EUROSTARS

Autor: Jon Eigill Johansen, Huiling Liu, Jenny Button, Matthew Connolly, Johannes Tveit, Craig Mckenzie, Henrik Green, Johan Dahlen, Xiongyu Wu, Peter Konradsson

Publikováno v: Toxicologie Analytique et Clinique. 34:S123-S124

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ec31436ffb3b16db1f6264a1f8719d75
https://doi.org/10.1016/j.toxac.2022.06.201

Concise Synthesis of Potential 4-Hydroxy-5-fluoropentyl Side-Chain Metabolites of Four Synthetic Cannabinoids

Autor: Huiling Liu, Xiongyu Wu, Erik Vestling, Jakob Wallgren, Johan Dahlén, Peter Konradsson, Anders Rexander

Publikováno v: Synlett. 31:517-520

Synthetic cannabinoids are a group of compounds that act on the CB1 receptor and are used illicitly as substitutes for cannabis. Given the rapid and extensive metabolism of synthetic cannabinoids, urinary biomarkers are essential if proof of drug int

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d84cc8b8cc10c85f18cb19c16812f029
https://doi.org/10.1055/s-0039-1691571

Synthetic resin acid derivatives selectively open the hK(V)7.2/7.3 channel and prevent epileptic seizures

Autor: Peter Konradsson, Michelle Nilsson, Malin Silverå Ejneby, Xiongyu Wu, Thomas A. Jepps, Urban Karlsson, Argel Estrada-Mondragón, Fredrik Elinder, Salomé Rognant, Melanie Schupp, Nina E. Ottosson

Publikováno v: Ottosson, N E, Ejneby, M S, Wu, X, Estrada-Mondragon, A, Nilsson, M, Karlsson, U, Schupp, M, Rognant, S, Jepps, T A, Konradsson, P & Elinder, F 2021, ' Synthetic resin acid derivatives selectively open the hK(V)7.2/7.3 channel and prevent epileptic seizures ', Epilepsia, vol. 62, no. 7, pp. 1744-1758 . https://doi.org/10.1111/epi.16932

Objective About one third of all patients with epilepsy have pharmacoresistant seizures. Thus there is a need for better pharmacological treatments. The human voltage-gated potassium (hK(V)) channel hK(V)7.2/7.3 is a validated antiseizure target for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43b80e815713c1101190996e21db2cc8
https://curis.ku.dk/ws/files/272246120/Synthetic_resin_acid_derivatives_selectively_open.pdf