Zobrazeno 1 - 10
of 226
pro vyhledávání: '"Peter Gerber*"'
Publikováno v:
mAbs, Vol 15, Iss 1 (2023)
ABSTRACTThe commentary by Colombo and Rich recently published in Cancer Cell provides a timely and comprehensive review of the clinical maximum tolerated doses (MTDs) of antibody−drug conjugates (ADCs) and their corresponding small molecules/chemot
Externí odkaz:
https://doaj.org/article/673ab86c44f94f4f85c9c6e310d5b5a6
Autor:
Hans-Peter Gerber, Leonard G. Presta
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
pHLA complexes represent the largest class of cell surface markers on cancer cells, making them attractive for targeted cancer therapies. Adoptive cell therapies expressing TCRs that recognize tumor specific pHLAs take advantage of the unique selecti
Externí odkaz:
https://doaj.org/article/3d9bcbd576b6440697b903d4530142d0
Autor:
Kenneth G. Geles, Yijie Gao, Andreas Giannakou, Latha Sridharan, Ting-Ting Yamin, Jing Zhang, Riyez Karim, Joel Bard, Nicole Piche-Nicholas, Manoj Charati, Andreas Maderna, Judy Lucas, Jonathon Golas, Magali Guffroy, Steven Pirie-Shepherd, Marc Roy, Jessie Qian, Tania Franks, Wenyan Zhong, Christopher J. O’Donnell, Lioudmila Tchistiakova, Hans-Peter Gerber, Puja Sapra
Publikováno v:
Cell Reports Medicine, Vol 2, Iss 5, Pp 100279- (2021)
Summary: Aberrant NOTCH3 signaling and overexpression is oncogenic, associated with cancer stem cells and drug resistance, yet therapeutic targeting remains elusive. Here, we develop NOTCH3-targeted antibody drug conjugates (NOTCH3-ADCs) by bioconjug
Externí odkaz:
https://doaj.org/article/76d0c5083adc4e25955529b3fcfbbf6d
Autor:
Florian Heil, Galina Babitzki, Alice Julien-Laferriere, Chia-Huey Ooi, Manuel Hidalgo, Christophe Massard, Maria Martinez-Garcia, Christophe Le Tourneau, Mark Kockx, Peter Gerber, Simona Rossomanno, Oliver Krieter, Angelika Lahr, Norbert Wild, Suzana Vega Harring, Katharina Lechner
Publikováno v:
Translational Oncology, Vol 14, Iss 2, Pp 100984- (2021)
Vanucizumab is a novel bispecific antibody inhibiting vascular endothelial growth factor (VEGF-A) and angiopoietin-2 (Ang-2) that demonstrated safety and anti-tumor activity in part I of a phase I study of 42 patients with advanced solid tumors. Part
Externí odkaz:
https://doaj.org/article/ed93c95472434a2ab2071afec0adca67
Publikováno v:
Nano and Micro‐Scale Energetic Materials. :683-732
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ed73f6bdee84d2337e6586152f1e823b
https://doi.org/10.1002/9783527835348.ch22
https://doi.org/10.1002/9783527835348.ch22
Publikováno v:
Surgery for Obesity and Related Diseases. 18:1313-1322
Whether patients aged 60 years or older should be recommended bariatric surgery is still controversial.To assess the effect of age on health-related quality of life (QoL) over time after gastric bypass.Data from the Swedish national registry for bari
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::735969b8ff1147e6e9402358f35e599f
https://doi.org/10.1016/j.soard.2022.06.017
https://doi.org/10.1016/j.soard.2022.06.017
Autor:
Frank Loganzo, Hans-Peter Gerber, Judy Lucas, Edward Rosfjord, Jeremy S. Myers, Russell Dushin, Dahui Zhou, Lindsay King, Laurie Tylaska, Fang Wang, Christine Hosselet, Jonathan Golas, Bingwen Lu, Xingzhi Tan, Matthew Sung
Trastuzumab emtansine (T-DM1) is an antibody–drug conjugate (ADC) that has demonstrated clinical benefit for patients with HER2+ metastatic breast cancer; however, its clinical activity is limited by inherent or acquired drug resistance. The molecu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::98b7849b4a80f721f9c5c51b80a5df70
https://doi.org/10.1158/1535-7163.c.6537949.v1
https://doi.org/10.1158/1535-7163.c.6537949.v1
Autor:
Puja Sapra, Hans-Peter Gerber, Christopher J. O'Donnell, Frank Loganzo, Edward Rosfjord, Judy Lucas, Lioudmila Tchistiakova, Frank Barletta, Tracey Clark, Martin Finkelstein, Hadi Falahatpisheh, Magali Guffroy, George Hu, Cynthia M. Rohde, Christine Hosselet, Jonathon Golas, Manoj B. Charati, Eric M. Bennett, Jeffrey Casavant, Jack Bikker, L. Nathan Tumey, Sujiet Puthenveetil, Kimberly Marquette, Bitha Narayanan, Dangshe Ma, Matthew Sung, Edmund I. Graziani
Effects of Systemic Administration of Free Payload Compared with Conventional HER2-vc0101 on Indicators of Bone Marrow Toxicity and Bone Marrow Payload Levels in Rats
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d432b6130242412350911c126917be78
https://doi.org/10.1158/1535-7163.22520919.v1
https://doi.org/10.1158/1535-7163.22520919.v1
Autor:
Puja Sapra, Hans-Peter Gerber, Christopher J. O'Donnell, Frank Loganzo, Edward Rosfjord, Judy Lucas, Lioudmila Tchistiakova, Frank Barletta, Tracey Clark, Martin Finkelstein, Hadi Falahatpisheh, Magali Guffroy, George Hu, Cynthia M. Rohde, Christine Hosselet, Jonathon Golas, Manoj B. Charati, Eric M. Bennett, Jeffrey Casavant, Jack Bikker, L. Nathan Tumey, Sujiet Puthenveetil, Kimberly Marquette, Bitha Narayanan, Dangshe Ma, Matthew Sung, Edmund I. Graziani
The approval of ado-trastuzumab emtansine (T-DM1) in HER2+ metastatic breast cancer validated HER2 as a target for HER2-specific antibody–drug conjugates (ADC). Despite its demonstrated clinical efficacy, certain inherent properties within T-DM1 ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a1b894a20379dc9a76f654d4811688b
https://doi.org/10.1158/1535-7163.c.6542832
https://doi.org/10.1158/1535-7163.c.6542832
Autor:
Puja Sapra, Hans-Peter Gerber, Christopher J. O'Donnell, Frank Loganzo, Edward Rosfjord, Judy Lucas, Lioudmila Tchistiakova, Frank Barletta, Tracey Clark, Martin Finkelstein, Hadi Falahatpisheh, Magali Guffroy, George Hu, Cynthia M. Rohde, Christine Hosselet, Jonathon Golas, Manoj B. Charati, Eric M. Bennett, Jeffrey Casavant, Jack Bikker, L. Nathan Tumey, Sujiet Puthenveetil, Kimberly Marquette, Bitha Narayanan, Dangshe Ma, Matthew Sung, Edmund I. Graziani
Immunohistochemical evaluation of HER2 expression in vivo cell line and patient-derived xenograft models.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d3ff9f7c862c417038a9aae79602e4f
https://doi.org/10.1158/1535-7163.22520937
https://doi.org/10.1158/1535-7163.22520937