Výsledky vyhledávání - "Peter Facchini"

Bioproduction platform using a novel cane toad (Rhinella marina) N-methyltransferase for psychedelic-inspired drug discovery

Autor: Xue Chen, Jing Li, Lisa Yu, D Dhananjaya, Francesca Maule, Sarah Cook, Limei Chang, Jonathan Gallant, David Press, Jaideep S Bains, Sheetal Raithatha, Jillian Hagel, Peter Facchini

Psychedelic indolethylamines have emerged as potential medicines to treat several psychiatric pathologies. Natural sources of these compounds include ‘magic mushrooms’, plants used to prepare ahayuasca, and toads. Owing to the occurrence of indol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2041370b22e0b866e537d96f150e33b8
https://doi.org/10.21203/rs.3.rs-2667175/v1

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Elucidation of the (R)-enantiospecific benzylisoquinoline alkaloid biosynthetic pathways in sacred lotus (Nelumbo nucifera)

Autor: Ivette María Menéndez Perdomo, Peter Facchini

Publikováno v: Scientific Reports. 13

Benzylisoquinoline alkaloids (BIAs) are a structurally diverse group of plant specialized metabolites found mainly in members of the order Ranunculales, including opium poppy (Papaver somniferum), for which BIA biosynthetic pathways leading to the cr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0306284a745521baed6a10befb407bae
https://doi.org/10.1038/s41598-023-29415-0

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Phloem-specific localization of benzylisoquinoline alkaloid metabolism in opium poppy

Autor: Natali Ozber, Peter Facchini

Publikováno v: Journal of Plant Physiology. 271:153641

Opium poppy is the only commercial source of the narcotic analgesics morphine and codeine, and semi-synthetic derivatives of the natural opiate precursor thebaine, including oxycodone and the opioid antagonist naloxone. The plant also accumulates the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8025088d66ef04094c7921b69cd7f0e6
https://doi.org/10.1016/j.jplph.2022.153641

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Akademický článek

Biochemistry and occurrence of O-demethylation in plant metabolism

Autor: Jillian Hagel, Peter Facchini

Publikováno v: Frontiers in Physiology, Vol 1 (2010)

Demethylases play a pivitol role in numerous biological processes from covalent histone modification and DNA repair to specialized metabolism in plants and microorganisms. Enzymes that catalyze O- and N-demethylation include 2-oxoglutarate (2OG)/Fe(I

Externí odkaz: https://doaj.org/article/2c03aa46af994edda47beaf349f0f62e

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