Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Peter Axerio-Cilies"'
Autor:
Ya Wen, Zhifang Dong, Jun Liu, Peter Axerio-Cilies, Yehong Du, Junjie Li, Long Chen, Lu Zhang, Lidong Liu, Jie Lu, Ning Zhou, Dong Chuan Wu, Yu Tian Wang
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 7, Iss 1, Pp 1-18 (2022)
Abstract Maintaining a proper balance between the glutamate receptor-mediated neuronal excitation and the A type of GABA receptor (GABAAR) mediated inhibition is essential for brain functioning; and its imbalance contributes to the pathogenesis of ma
Externí odkaz:
https://doaj.org/article/133ea9a75bc840049467928b191b5e7f
Autor:
Yun-Fei Bai, Michelle Chiu, Elizabeth S. Chan, Peter Axerio-Cilies, Jie Lu, Linda Huh, Mary B. Connolly, Ilaria Guella, Matthew J. Farrer, Zhi-Qing David Xu, Lidong Liu, Michelle Demos, Yu Tian Wang
Publikováno v:
Molecular Brain, Vol 12, Iss 1, Pp 1-17 (2019)
Abstract We report the identification of a de novo GABRA1 (R214C) variant in a child with epileptic encephalopathy (EE), describe its functional characterization and pathophysiology, and evaluate its potential therapeutic options. The GABRA1 (R214C)
Externí odkaz:
https://doaj.org/article/05079710b492409489c8147725986750
Autor:
Yun-Fei Bai, Michelle Chiu, Elizabeth S. Chan, Peter Axerio-Cilies, Jie Lu, Linda Huh, Mary B. Connolly, Ilaria Guella, Matthew J. Farrer, Zhi-Qing David Xu, Lidong Liu, Michelle Demos, Yu Tian Wang
Publikováno v:
Molecular Brain, Vol 13, Iss 1, Pp 1-2 (2020)
Following publication of the original article [1], the authors reported errors in Figure 4.
Externí odkaz:
https://doaj.org/article/d664bc76a5bc4aeaa93f3ae36e366f5e
Autor:
Artem Cherkasov, Paul S. Rennie, Emma Tomlinson Guns, Helge Prinz, Konrad J. Böhm, Hans Adomat, Kriti Singh, Kate Frewin, Natalia Kanaan, Peyman Tavassoli, Eric Leblanc, Peter Axerio-Cilies, Nathan A. Lack, Mohamed D.H. Hassona, Huifang Li
PDF file, 162K, AR mRNA levels are unaffected upon treatment with VPC-3022 and VPC-3033. Total RNA was extracted after treatment of LNCaP and MDV3100-resistant cells with VPC-3022 and VPC-3033 for 24 hours at the indicated concentrations in the prese
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0406c04cd1febb6f269dbf52c712dfe4
https://doi.org/10.1158/1535-7163.22499370.v1
https://doi.org/10.1158/1535-7163.22499370.v1
Autor:
Artem Cherkasov, Paul S. Rennie, Emma Tomlinson Guns, Helge Prinz, Konrad J. Böhm, Hans Adomat, Kriti Singh, Kate Frewin, Natalia Kanaan, Peyman Tavassoli, Eric Leblanc, Peter Axerio-Cilies, Nathan A. Lack, Mohamed D.H. Hassona, Huifang Li
PDF file, 122K.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3aed416d5740000364665d25954a263
https://doi.org/10.1158/1535-7163.22499358.v1
https://doi.org/10.1158/1535-7163.22499358.v1
Autor:
Artem Cherkasov, Paul S. Rennie, Emma Tomlinson Guns, Helge Prinz, Konrad J. Böhm, Hans Adomat, Kriti Singh, Kate Frewin, Natalia Kanaan, Peyman Tavassoli, Eric Leblanc, Peter Axerio-Cilies, Nathan A. Lack, Mohamed D.H. Hassona, Huifang Li
PDF file, 2136K, (A) Effect of VPC-3022 on AR activity in HeLa-AR cells in the presence of cyclohexamide. HeLa-AR cells were treated with serially-diluted concentrations of VPC-3022 (0 - 100 ?M) with or without 10 ?M of cyclohexamide for 8 hours, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14071971750f52e50a971a94974714b0
https://doi.org/10.1158/1535-7163.22499367.v1
https://doi.org/10.1158/1535-7163.22499367.v1
Autor:
Artem Cherkasov, Paul S. Rennie, Emma Tomlinson Guns, Helge Prinz, Konrad J. Böhm, Hans Adomat, Kriti Singh, Kate Frewin, Natalia Kanaan, Peyman Tavassoli, Eric Leblanc, Peter Axerio-Cilies, Nathan A. Lack, Mohamed D.H. Hassona, Huifang Li
PDF file, 1976K, (A) Inhibition of in vitro polymerization of tubulin at 37 {degree sign}C by various concentrations of VPC-3033; turbidity was recorded at 360 nM.The steady-state tubulin assembly level in the absence of inhibitor was set at 100%. (B
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d188b9669c9362a95eae66c4df6dfc18
https://doi.org/10.1158/1535-7163.22499361
https://doi.org/10.1158/1535-7163.22499361
Autor:
Artem Cherkasov, Paul S. Rennie, Emma Tomlinson Guns, Helge Prinz, Konrad J. Böhm, Hans Adomat, Kriti Singh, Kate Frewin, Natalia Kanaan, Peyman Tavassoli, Eric Leblanc, Peter Axerio-Cilies, Nathan A. Lack, Mohamed D.H. Hassona, Huifang Li
PDF file, 3480K, The binding pose of DHT (A) and VPC-3022 with AR by molecular docking (B) and binding pose of VPC-3022 with AR after 10 ns molecular dynamics (C); RMSD values of the protein backbone, protein-ligand, ligand in the 10 ns molecular dyn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34aa3c1da8ca184de04da05a59d985aa
https://doi.org/10.1158/1535-7163.22499364
https://doi.org/10.1158/1535-7163.22499364
Autor:
Artem Cherkasov, Paul S. Rennie, Emma Tomlinson Guns, Helge Prinz, Konrad J. Böhm, Hans Adomat, Kriti Singh, Kate Frewin, Natalia Kanaan, Peyman Tavassoli, Eric Leblanc, Peter Axerio-Cilies, Nathan A. Lack, Mohamed D.H. Hassona, Huifang Li
The human androgen receptor plays a major role in the development and progression of prostate cancer and represents a well-established drug target. All clinically approved androgen receptor antagonists possess similar chemical structures and exhibit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35b77f02358c43c74ce57845da551d74
https://doi.org/10.1158/1535-7163.c.6536130.v1
https://doi.org/10.1158/1535-7163.c.6536130.v1
Autor:
Artem Cherkasov, Paul S. Rennie, Emma Tomlinson Guns, Helge Prinz, Konrad J. Böhm, Hans Adomat, Kriti Singh, Kate Frewin, Natalia Kanaan, Peyman Tavassoli, Eric Leblanc, Peter Axerio-Cilies, Nathan A. Lack, Mohamed D.H. Hassona, Huifang Li
PDF file, 109K, Inhibition of VPC-3022 against wild-type AR in HeLa-AR cells. HeLa-AR cells transfected with ARR3tk-luciferase reporter were treated with VPC-3022 for 24 hours in various concentrations in the presence of 0.1 nM R1881. Error bars indi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2753eee2829568689bdd1b107cc06191
https://doi.org/10.1158/1535-7163.22499373.v1
https://doi.org/10.1158/1535-7163.22499373.v1