Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Peter 't Hart"'
Autor:
Jessica Nowacki, Mateo Malenica, Stefan Schmeing, Damian Schiller, Benjamin Buchmuller, Gulshan Amrahova, Peter ‘t Hart
Publikováno v:
RNA Biology, Vol 20, Iss 1, Pp 85-94 (2023)
RNA-binding proteins are essential regulators of RNA processing and function. Translational repression assays can be used to study how they interact with specific RNA sequences by insertion of such a consensus sequence into the 5’ untranslated regi
Externí odkaz:
https://doaj.org/article/42128930513d4dbe8d47d44da24a0786
Autor:
Sunit Pal, Peter ‘t Hart
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Being able to effectively target RNA with potent ligands will open up a large number of potential therapeutic options. The knowledge on how to achieve this is ever expanding but an important question that remains open is what chemical matter is suita
Externí odkaz:
https://doaj.org/article/03b3ed734786460d9ac3528818a22335
Autor:
Adrian Krzyzanowski, Lea Marie Esser, Anthony Willaume, Renaud Prudent, Christoph Peter, Peter ‘t Hart, Herbert Waldmann
Publikováno v:
Journal of Medicinal Chemistry. 65:15300-15311
The PRMT5-MEP50 methyltransferase is a major target for anticancer drug discovery, and modulators of its interactions with different regulatory proteins are in high demand because they modulate PRMT5 substrate selectivity. We describe a strategy for
Autor:
Jessica Nowacki, Mateo Malenica, Stefan Schmeing, Damian Schiller, Benjamin Buchmuller, Peter ‘t Hart
RNA-binding proteins are essential regulators of RNA processing and function. Translational repression assays can be used to study how they interact with specific RNA sequences by insertion of such a consensus sequence into the 5’ untranslated regi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a21d48f3f0eee49c8a21b9e16a373f13
https://doi.org/10.1101/2022.09.05.506580
https://doi.org/10.1101/2022.09.05.506580
Publikováno v:
Chemistry – A European Journal. 28
Publikováno v:
Chembiochem
The PRMT5–MEP50 methyltransferase complex plays a key role in various cancers and is regulated by different protein–protein interactions. Several proteins have been reported to act as adaptor proteins that recruit substrate proteins to the active
Autor:
Ingrid R. Vetter, Hélène Adihou, Darijan Schüler, Arthur T. Porfetye, Adrian Krzyzanowski, Mohammad Akbarzadeh, Herbert Waldmann, Pascal Hommen, Anaïs F. M. Noisier, Peter 't Hart
Publikováno v:
Angewandte Chemie (International Ed. in English)
The scaffolding protein RbAp48 is part of several epigenetic regulation complexes and is overexpressed in a variety of cancers. In order to develop tool compounds for the study of RbAp48 function, we have developed peptide inhibitors targeting the pr
Publikováno v:
ChemBioChem. 22:1852-1852
Autor:
Thomas M. Wood, Małgorzata Śleszyńska, Nathaniel I. Martin, Antoni P. A. Hendrickx, Eefjan Breukink, Peter 't Hart, Rob J. L. Willems, Inmaculada Rentero Rebollo, Kamaleddin Haj Mohammad Ebrahim Tehrani, Roel M. van Harten
Publikováno v:
Chemical Science, 8(12), 7991. Royal Society of Chemistry
Chemical Science, 8(12), 7991-7997
Chemical Science, 8(12), 7991-7997
Creative strategies for identifying new antibiotics are essential to addressing the looming threat of a post-antibiotic era. We here report the use of a targeted peptide phage display screen as a means of generating novel antimicrobial lipopeptides.
Publikováno v:
Tetrahedron. 75:130685
New modalities such as cyclic peptides are attractive structures to inhibit challenging targets. The interaction between LSD1 and CoREST1 is required for histone demethylation and represents an attractive therapeutic target. The large interaction sur