Výsledky vyhledávání - "Peter, van der Ley"

Akademický článek

Shortening the Lipid A Acyl Chains of Bordetella pertussis Enables Depletion of Lipopolysaccharide Endotoxic Activity

Autor: Jesús Arenas, Elder Pupo, Coen Phielix, Dionne David, Afshin Zariri, Alla Zamyatina, Jan Tommassen, Peter van der Ley

Publikováno v: Vaccines, Vol 8, Iss 4, p 594 (2020)

Whooping cough, or pertussis, is an acute respiratory infectious disease caused by the Gram-negative bacterium Bordetella pertussis. Whole-cell vaccines, which were introduced in the fifties of the previous century and proved to be effective, showed

Externí odkaz: https://doaj.org/article/20bfbbe2c0ae4a96b351122682a80f4b

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Lipid A heterogeneity and its role in the host interactions with pathogenic and commensal bacteria

Autor: Sukumar Saha, Elder Pupo, Afshin Zariri, Peter van der Ley

Publikováno v: microLife. 3

Lipopolysaccharide (LPS) is for most but not all Gram-negative bacteria an essential component of the outer leaflet of the outer membrane. LPS contributes to the integrity of the outer membrane, which acts as an effective permeability barrier to anti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::002f938d2131792fc804b9960cab34d1
https://doi.org/10.1093/femsml/uqac011

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Nanoflow LC-MS Method Allowing In-Depth Characterization of Natural Heterogeneity of Complex Bacterial Lipopolysaccharides

Autor: Peter van der Ley, Elder Pupo, Hugo D. Meiring

Publikováno v: Analytical chemistry. 93(48)

The variable modification of the outer membrane lipopolysaccharide (LPS) in Gram-negative bacteria contributes to bacterial pathogenesis through various mechanisms, including the development of antibiotic resistance and evasion of the immune response

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::272f04cf7af5b5e5341de1e59c720b59
https://pubmed.ncbi.nlm.nih.gov/34807566

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An intranasal OMV-based vaccine induces high mucosal and systemic protecting immunity against a SARS-CoV-2 infection

Autor: Dinja Oosterhoff, Elly van Riet, Peter van der Ley, Corine Kruiswijk, Afshin Zariri

Publikováno v: Frontiers in Immunology
Frontiers in Immunology, Vol 12 (2021)

The development of more effective, accessible, and easy to administer COVID-19 vaccines next to the currently marketed mRNA, viral vector, and whole inactivated virus vaccines is essential to curtailing the SARS-CoV-2 pandemic. A major concern is red

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d3261a54dcdbe0843ff6386a6e3e482
https://doi.org/10.1101/2021.08.25.457644

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Akademický článek

Human lipoproteins have divergent neutralizing effects on E. coli LPS, N. meningitidis LPS, and complete Gram-negative bacteria

Autor: Tom Sprong, Mihai G. Netea, Peter van der Ley, Trees J.G. Verver-Jansen, Liesbeth E.H. Jacobs, Anton Stalenhoef, Jos W.M. van der Meer, Marcel van Deuren

Publikováno v: Journal of Lipid Research, Vol 45, Iss 4, Pp 742-749 (2004)

The use of lipoproteins has been suggested as a treatment for Gram-negative sepsis because they inhibit lipopolysaccharide (LPS)-mediated cytokine production. However, little is known about the neutralizing effects of lipoproteins on cytokine product

Externí odkaz: https://doaj.org/article/f14ca0d433f7445bb238358b7c1f9656

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Rational Vaccine Design in Times of Emerging Diseases: The Critical Choices of Immunological Correlates of Protection, Vaccine Antigen and Immunomodulation

Autor: Alla Zamyatina, Antonio Molinaro, Cristina Nativi, Alberto Fernández-Tejada, Ihsan Gursel, Aneesh Thakur, Carmen Alvarez-Dominguez, Siobhán McClean, Peter van der Ley, Artur Summerfield, Camillo Rosano, Dragomira Majhen, Virgil E.J.C. Schijns, Sveinbjörn Gizurarson, Žiga Jakopin, Rita Berisio

Publikováno v: Schijns, Virgil; Majhen, Dragomira; van der Ley, Peter; Thakur, Aneesh; Summerfield, Artur; Berisio, Rita; Nativi, Cristina; Fernández-Tejada, Alberto; Alvarez-Dominguez, Carmen; Gizurarson, Sveinbjörn; Zamyatina, Alla; Molinaro, Antonio; Rosano, Camillo; Jakopin, Žiga; Gursel, Ihsan; McClean, Siobhán (2021). Rational Vaccine Design in Times of Emerging Diseases: The Critical Choices of Immunological Correlates of Protection, Vaccine Antigen and Immunomodulation. Pharmaceutics, 13(4) MDPI 10.3390/pharmaceutics13040501
Pharmaceutics
Pharmaceutics, Vol 13, Iss 501, p 501 (2021)
Schijns, V, Majhen, D, Van Der Ley, P, Thakur, A, Summerfield, A, Berisio, R, Nativi, C, Fernández-tejada, A, Álverez-dominguez, C, Gizurarson, S, Zamyatina, A, Molinaro, A, Rosano, C, Jakopin, Ž, Gursel, I & Mcclean, S 2021, ' Rational Vaccine Design in Times of Emerging Diseases: The Critical Choices of Immunological Correlates of Protection, Vaccine Antigen and Immunomodulation ', Pharmaceutics, vol. 13, no. 4, 501 . https://doi.org/10.3390/pharmaceutics13040501

Vaccines are the most effective medical intervention due to their continual success in preventing infections and improving mortality worldwide. Early vaccines were developed empirically however, rational design of vaccines can allow us to optimise th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5ab37e2248edd84bf4a4d441bb02f43
https://boris.unibe.ch/157742/1/b157742.pdf

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Akademický článek

Correction: Construction of Opa-Positive and Opa-Negative Strains of to Evaluate a Novel Meningococcal Vaccine.

Autor: Manish Sadarangani, J. Claire Hoe, Martin J. Callaghan, Claire Jones, Hannah Chan, Katherine Makepeace, Hélène Daniels-Treffandier, Mary E. Deadman, Christopher Bayliss, Ian Feavers, Peter van der Ley, Andrew J. Pollard

Publikováno v: PLoS ONE, Vol 8, Iss 10 (2013)

Externí odkaz: https://doaj.org/article/40a3ee41a3d94954b8df946c2a8b21f5

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Akademický článek

Cysteine depletion causes oxidative stress and triggers outer membrane vesicle release by Neisseria meningitidis; implications for vaccine development.

Autor: Bas van de Waterbeemd, Gijsbert Zomer, Jan van den Ijssel, Lonneke van Keulen, Michel H Eppink, Peter van der Ley, Leo A van der Pol

Publikováno v: PLoS ONE, Vol 8, Iss 1, p e54314 (2013)

Outer membrane vesicles (OMV) contain immunogenic proteins and contribute to in vivo survival and virulence of bacterial pathogens. The first OMV vaccines successfully stopped Neisseria meningitidis serogroup B outbreaks but required detergent-extrac

Externí odkaz: https://doaj.org/article/fef846d00b9043988082da0ff14b3826

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Akademický článek

Prevalence and clinical course in invasive infections with meningococcal endotoxin variants.

Autor: Gerwin D Rodenburg, Floris Fransen, Debby Bogaert, Kim Schipper, Rolf H H Groenwold, Hendrik Jan Hamstra, Brenda M Westerhuis, Diederik van de Beek, Peter van der Ley, Elisabeth A M Sanders, Arie van der Ende

Publikováno v: PLoS ONE, Vol 7, Iss 11, p e49295 (2012)

BACKGROUND: Meningococci produce a penta-acylated instead of hexa-acylated lipid A when their lpxL1 gene is inactivated. Meningococcal strains with such lipid A endotoxin variants have been found previously in adult meningitis patients, where they ca

Externí odkaz: https://doaj.org/article/51c764711b114a00b4cb7bb3e75173bd

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