Bone Marrow–Harvesting Technique Influences Functional Heterogeneity of Mesenchymal Stem/Stromal Cells and Cartilage Regeneration

Autor: Wendy Koevoet, Elena Jones, Peter de Zwart, Kavitha Sivasubramaniyan, Heather E. Owston, Gerjo J.V.M. van Osch, Abhishek Harichandan, Diego L Santos, Hans-Jörg Bühring, Pieter K. Bos, Dragos C Ilas

Publikováno v: The American Journal of Sports Medicine
American Journal of Sports Medicine, 46(14), 3521-3531. SAGE Publishing
The American Journal of Sports Medicine, 46(14), 3521-3531. SAGE Publications Inc.

Background: Connective tissue progenitors (CTPs) from native bone marrow (BM) or their culture-expanded progeny, often referred to as mesenchymal stem/stromal cells, represents a promising strategy for treatment of cartilage injuries. But the cartila

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2d5b4e986440646608e021722434d09
http://europepmc.org/articles/PMC6282158

Implantation einer modularen Knietotalendoprothese mit distalem Femurersatz mit kompressiver Osteointegration als Rückzugsoption bei komplexer femoraler posttraumatischer Ausgangssituation

Autor: Christian Arnscheidt, Björn Gunnar Ochs, Peter de Zwart, Anna J. Schreiner, Ulrich Stöckle

Publikováno v: Zeitschrift für Orthopädie und Unfallchirurgie. 156:200-204

Zusammenfassung Hintergrund Größere Knochendefekte und -verluste sind sowohl in der Tumorchirurgie als auch in der komplexen Primär- und Revisionsendoprothetik des Kniegelenks für die Rekonstruktion ausschlaggebend. Die gängige Option der zement

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8a4377518ed3e3e2becdd0829bee64b8
https://doi.org/10.1055/s-0043-120072

Crucial Role of Vitamin D in the Musculoskeletal System

Autor: Ingo Flesch, Christoph Ihle, Sabrina Ehnert, Elke Wintermeyer, Andreas K. Nussler, Peter de Zwart, Christian Bahrs, Ulrich Stöckle, Gunnar Ochs

Publikováno v: Nutrients
Nutrients, Vol 8, Iss 6, p 319 (2016)

Vitamin D is well known to exert multiple functions in bone biology, autoimmune diseases, cell growth, inflammation or neuromuscular and other immune functions. It is a fat-soluble vitamin present in many foods. It can be endogenously produced by ult

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fa3ead931a146d42e1fbc47c48adc32
http://europepmc.org/articles/PMC4924160

Phenotypic and functional heterogeneity of human bone marrow- and amnion-derived MSC subsets

Autor: Hans-Jörg Bühring, Elisabeth Mortha, Flavianna Cerabona, Peter de Zwart, Kavitha Sivasubramaniyan, Christoph Faul, Lothar Kanz, Sabrina Grimm, Roshanak Ghazanfari, Abhishek Harichandan, Neli Petkova, Harald Abele, Wilhelm K. Aicher, Daniela Lehnen, Malgorzata Sobiesiak

Publikováno v: Annals of the New York Academy of Sciences. 1266:94-106

Bone marrow-derived mesenchymal stromal/stem cells (MSCs) are nonhematopoietic cells that are able to differentiate into osteoblasts, adipocytes, and chondrocytes. In addition, they are known to participate in niche formation for hematopoietic stem c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3e9fa44eca3cc7ed0df37835ef846dd0
https://doi.org/10.1111/j.1749-6632.2012.06551.x

TGF-β Enhances the Integrin α2β1-Mediated Attachment of Mesenchymal Stem Cells to Type I Collagen

Autor: Diana Meckbach, Gerd Klein, Michaela Weis-Klemm, Katrin Warstat, Peter de Zwart, Wilhelm K. Aicher, Anita Hack

Publikováno v: Stem Cells and Development. 19:645-656

The heterodimeric integrins are important receptors for the attachment of cells to their extracellular matrix. Here, we studied the attachment of human mesenchymal stem cells (MSCs) to type I collagen (col-1), which is part of the extracellular matri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca9c20c0bea0a3113cfa9bf996b44f49
https://doi.org/10.1089/scd.2009.0208