Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Peter, Verstraelen"'
Autor:
Peter Verstraelen, Samuel Van Remoortel, Nouchin De Loose, Rosanne Verboven, Gerardo Garcia-Diaz Barriga, Anne Christmann, Manuela Gries, Shingo Bessho, Jing Li, Carmen Guerra, Çagla Tükel, Sales Ibiza Martinez, Karl-Herbert Schäfer, Jean-Pierre Timmermans, Winnok H. De Vos
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 18, Iss 1, Pp 89-104 (2024)
Background & Aims: Mounting evidence suggests the gastrointestinal microbiome is a determinant of peripheral immunity and central neurodegeneration, but the local disease mechanisms remain unknown. Given its potential relevance for early diagnosis an
Externí odkaz:
https://doaj.org/article/9e6f75de89f84982823a97136cab22fe
Publikováno v:
STAR Protocols, Vol 5, Iss 2, Pp 102957- (2024)
Summary: Neurological disorders are defined by synaptic dysfunction. We present a workflow to quantify morphological and functional aspects of synaptic connectivity in neuronal cultures and obtain an integrated readout. We describe steps for measurin
Externí odkaz:
https://doaj.org/article/cd3a05fbba87465e94bba757e597ca52
Autor:
Marlies Verschuuren, Peter Verstraelen, Gerardo García-Díaz Barriga, Ines Cilissen, Emma Coninx, Mieke Verslegers, Peter H. Larsen, Rony Nuydens, Winnok H. De Vos
Publikováno v:
Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-16 (2019)
Abstract Therapeutic developments for neurodegenerative disorders are redirecting their focus to the mechanisms that contribute to neuronal connectivity and the loss thereof. Using a high-throughput microscopy pipeline that integrates morphological a
Externí odkaz:
https://doaj.org/article/3252747729954b5db9d630506798f41d
Autor:
Peter Verstraelen, Gerardo Garcia-Diaz Barriga, Marlies Verschuuren, Bob Asselbergh, Rony Nuydens, Peter H. Larsen, Jean-Pierre Timmermans, Winnok H. De Vos
Publikováno v:
iScience, Vol 23, Iss 9, Pp 101542- (2020)
Summary: Most neurological disorders display impaired synaptic connectivity. Hence, modulation of synapse formation may have therapeutic relevance. However, the high density and small size of synapses complicate their quantification. To improve synap
Externí odkaz:
https://doaj.org/article/594e61b4f8c74d69baf9ff38d56cc205
Autor:
Peter Verstraelen, Michiel Van Dyck, Marlies Verschuuren, Nachiket D. Kashikar, Rony Nuydens, Jean-Pierre Timmermans, Winnok H. De Vos
Publikováno v:
Frontiers in Neuroscience, Vol 12 (2018)
Neurological disorders display a broad spectrum of clinical manifestations. Yet, at the cellular level, virtually all these diseases converge into a common phenotype of dysregulated synaptic connectivity. In dementia, synapse dysfunction precedes neu
Externí odkaz:
https://doaj.org/article/41e91a41f5c24492985beb2d16e0b9c1
Autor:
Ranhua Xiong, Peter Verstraelen, Jo Demeester, Andre G. Skirtach, Jean-Pierre Timmermans, Stefaan C. De Smedt, Winnok H. De Vos, Kevin Braeckmans
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 12 (2018)
Neurodevelopmental and neurodegenerative disorders are characterized by subtle alterations in synaptic connections and perturbed neuronal network functionality. A hallmark of neuronal connectivity is the presence of dendritic spines, micron-sized pro
Externí odkaz:
https://doaj.org/article/a4e68f9c39c843f9a3325154ee168073
Autor:
Juan D. Pita-Almenar, Winnok H. De Vos, Rajiv K. Mishra, Michiel Van Dyck, Francisco Pestana, Hilde Lavreysen, Peter Verstraelen, Nachiket D. Kashikar
Publikováno v:
Neuroinformatics
NeuroInformatics
NeuroInformatics
Synaptic dysfunction is a hallmark of various neurodegenerative and neurodevelopmental disorders. To interrogate synapse function in a systematic manner, we have established an automated high-throughput imaging pipeline based on fluorescence microsco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edecbc4063f8259c0789bda721e723ef
https://doi.org/10.1007/s12021-021-09536-5
https://doi.org/10.1007/s12021-021-09536-5
Autor:
Peter Verstraelen, Jan R. Detrez, Marlies Verschuuren, Jacobine Kuijlaars, Rony Nuydens, Jean-Pierre Timmermans, Winnok H. De Vos
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 11 (2017)
Functionally related neurons assemble into connected networks that process and transmit electrochemical information. To do this in a coordinated manner, the number and strength of synaptic connections is tightly regulated. Synapse function relies on
Externí odkaz:
https://doaj.org/article/585479908afb4390bea4001ce61e977f
Autor:
Peter Verstraelen, Samuel Van Remoortel, Nouchin De Loose, Rosanne Verboven, Gerardo Garcia-Diaz Barriga, Anne Christmann, Manuela Gries, Cagla Tükel, Sales Ibiza Martinez, Karl-Herbert Schäfer, Jean-Pierre Timmermans, Winnok H. De Vos
Mounting evidence suggests a role for the microbiome-gut-brain axis in amyloid-associated neurodegeneration, but the pathogenic changes induced by amyloids in the gastro-intestinal tract remain elusive. To scrutinize the early response to amyloids of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::032583285906723ca3372b67622d5c3d
https://doi.org/10.1101/2022.08.08.503156
https://doi.org/10.1101/2022.08.08.503156
Autor:
Ludo Van Den Bosch, Jonas Van Lent, Christophe Verbist, Bob Asselbergh, Kristel Eggermont, Winnok H. De Vos, Peter Verstraelen, Vincent Timmerman, Vicky De Winter, Ligia Mateiu, Elias Adriaenssens
Publikováno v:
Brain
Axonal Charcot-Marie-Tooth neuropathies (CMT type 2) are caused by inherited mutations in various genes functioning in different pathways. The types of genes and multiplicity of mutations reflect the clinical and genetic heterogeneity in CMT2 disease
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8764830405ef8208b63c8e609a4e8dc
https://doi.org/10.1093/brain/awab226
https://doi.org/10.1093/brain/awab226