Zobrazeno 1 - 10
of 294
pro vyhledávání: '"Peter, Sutovsky"'
Autor:
Fei Sun, Nourhan Nashat Ali, Daniela Londoño-Vásquez, Constantine A. Simintiras, Huanyu Qiao, M. Sofia Ortega, Yuksel Agca, Masashi Takahashi, Rocío M. Rivera, Andrew M. Kelleher, Peter Sutovsky, Amanda L. Patterson, Ahmed Z. Balboula
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract Unlike mild DNA damage exposure, DNA damage repair (DDR) is reported to be ineffective in full-grown mammalian oocytes exposed to moderate or severe DNA damage. The underlying mechanisms of this weakened DDR are unknown. Here, we show that m
Externí odkaz:
https://doaj.org/article/87dfd391b25f4e3e97ba122bfc727589
Autor:
Michal Zigo, Jacob Netherton, Natálie Zelenková, Karl Kerns, Veronika Kraus, Pavla Postlerová, Mark Baker, Peter Sutovsky
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-18 (2024)
Abstract Capacitation is an essential post-testicular maturation event endowing spermatozoa with fertilizing capacity within the female reproductive tract, significant for fertility, reproductive health, and contraception. By using a human-relevant l
Externí odkaz:
https://doaj.org/article/0ff92330ca3d4b5398908bbe077259fb
Autor:
Lindsey Fallon, Edgar Diaz-Miranda, Lauren Hamilton, Peter Sutovsky, Michal Zigo, Thomas E. Spencer, M. Sofia Ortega
Publikováno v:
Frontiers in Veterinary Science, Vol 10 (2023)
There is a current need for new biomarkers of spermatozoa quality, that consistently and correctly identify spermatozoa that will successfully contribute to subsequent embryo development. This could improve the standardization of semen analysis, decr
Externí odkaz:
https://doaj.org/article/4c84317102944d229677fc1e6488e530
Publikováno v:
eLife, Vol 12 (2023)
The degradation of sperm-borne mitochondria after fertilization is a conserved event. This process known as post-fertilization sperm mitophagy, ensures exclusively maternal inheritance of the mitochondria-harbored mitochondrial DNA genome. This mitoc
Externí odkaz:
https://doaj.org/article/18951314c6ad455fa7f239eb3fd296e1
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-12 (2022)
Zinc-interacting proteins in porcine sperm change during sperm maturation, particularly those associated with Huntington’s and Parkinson’s disease pathways.
Externí odkaz:
https://doaj.org/article/7e3fa0b28de94490b4df431dde055338
Autor:
Momal Sharif, Vincent Hickl, Gabriel Juarez, Xingjian Di, Karl Kerns, Peter Sutovsky, Nicolai Bovin, David J. Miller
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Fertilizing sperm are retained by adhesion to specific glycans on the epithelium of the oviduct forming a reservoir before sperm are released from the reservoir so fertilization can ensue. Capacitated sperm lose affinity for the oviduct epit
Externí odkaz:
https://doaj.org/article/7cec2a6ad13343bba896d7f5c999ef87
Autor:
Lenka Hackerova, Barbora Klusackova, Michal Zigo, Natalie Zelenkova, Katerina Havlikova, Romana Krejcirova, Marketa Sedmikova, Peter Sutovsky, Katerina Komrskova, Pavla Postlerova, Ondrej Simonik
Publikováno v:
Frontiers in Veterinary Science, Vol 10 (2023)
A series of biochemical and biophysical changes during sperm capacitation initiates various signaling pathways related to protein phosphorylation leading to sperm hyperactivation, simultaneously with the regulation of proteasomal activity responsible
Externí odkaz:
https://doaj.org/article/a6f08b13baed4eee98f077b1cf6674bd
Publikováno v:
Biomolecules, Vol 13, Iss 6, p 996 (2023)
Sperm capacitation is a complex process endowing biological and biochemical changes to a spermatozoon for a successful encounter with an oocyte. The present study focused on the role of the ubiquitin–proteasome system (UPS) in the remodeling of the
Externí odkaz:
https://doaj.org/article/2f8e3737de7946a3b94b9f78f2a73d0a
Autor:
Eriklis Nogueira, Filip Tirpák, Lauren E. Hamilton, Michal Zigo, Karl Kerns, Miriam Sutovsky, JaeWoo Kim, Dietrich Volkmann, Luca Jovine, Jeremy F. Taylor, Robert D. Schnabel, Peter Sutovsky
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
This study is part of a concerted effort to identify and phenotype rare, deleterious mutations that adversely affect sperm quality, or convey high developmental and fertility potential to embryos and ensuing progeny. A rare, homozygous mutation in EM
Externí odkaz:
https://doaj.org/article/fc990fac3292487aa7065b91da7cb39c
Publikováno v:
Animals, Vol 12, Iss 9, p 1130 (2022)
Cryopreservation and storage of semen for artificial insemination (AI) result in excessive accumulation of reactive oxygen species (ROS). This leads to a shortened life span and reduced motility of spermatozoa post-thawing, with consequent impairment
Externí odkaz:
https://doaj.org/article/76f4504800ad4315a922493bcd4fe846