Zobrazeno 1 - 10
of 215
pro vyhledávání: '"Peter, Reichard"'
Autor:
Vera Bianchi, Peter Reichard, Paola Ferraro, Chiara Rampazzo, Giovanna Pontarin, Cristina Miazzi
Publikováno v:
The Journal of Biological Chemistry
Background: Genetic loss of SAMHD1, a catabolic enzyme preventing dNTP accumulation outside S phase, leads to disease in humans but not in mice. Results: Allosteric regulation by dNTPs works similarly in pure recombinant human and mouse SAMHD1. Concl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45969bba4ffbdba8356e7fc23e1b0eab
http://europepmc.org/articles/PMC4140260
http://europepmc.org/articles/PMC4140260
Autor:
Lars Thelander, Peter Reichard, Vera Bianchi, Giovanna Pontarin, Paola Ferraro, Pelle Håkansson
Publikováno v:
Journal of Biological Chemistry. 282:16820-16828
Human fibroblasts in culture obtain deoxynucleotides by de novo ribonucleotide reduction or by salvage of deoxynucleosides. In cycling cells the de novo pathway dominates, but in quiescent cells the salvage pathway becomes important. Two forms of act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c81a1be47f5d707a7f8497ed85db9404
https://doi.org/10.1074/jbc.m701310200
https://doi.org/10.1074/jbc.m701310200
Autor:
Pär, Nordlund, Peter, Reichard
Publikováno v:
Annual Review of Biochemistry. 75:681-706
Ribonucleotide reductases (RNRs) transform RNA building blocks to DNA building blocks by catalyzing the substitution of the 2′OH-group of a ribonucleotide with a hydrogen by a mechanism involving protein radicals. Three classes of RNRs employ diffe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abd3adf38ac2ef09e573da08ea8163a5
https://doi.org/10.1146/annurev.biochem.75.103004.142443
https://doi.org/10.1146/annurev.biochem.75.103004.142443
Publikováno v:
Journal of Biological Chemistry. 281:5604-5611
Ribonucleotide reductases provide the building blocks for DNA synthesis. Three classes of enzymes are known, differing widely in amino acid sequence but with similar structural motives and allosteric regulation. Class I occurs in eukaryotes and aerob
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::69ffce2a8fe548e90155fa384c0f8fae
https://doi.org/10.1074/jbc.m512962200
https://doi.org/10.1074/jbc.m512962200
Autor:
Vera Bianchi, Chiara Rampazzo, Peter Reichard, Katia Crovatto, Giovanna Pontarin, Eva Milanesi, Paola Ferraro, Lisa Gallinaro
Publikováno v:
Journal of Biological Chemistry. 277:35080-35087
Deoxynucleoside triphosphates (dNTPs) used for mitochondrial DNA replication are mainly formed by phosphorylation of deoxynucleosides imported into mitochondria from the cytosol. We earlier obtained evidence for a mitochondrial 5′-nucleotidase (dNT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7ede33e26ecb5c9a6d444f0d91acef0c
https://doi.org/10.1074/jbc.m203755200
https://doi.org/10.1074/jbc.m203755200
Autor:
Peter Reichard
Publikováno v:
Journal of Biological Chemistry. 277:13355-13362
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1025a5b9a4ab301f447e7332ce8dec3b
https://doi.org/10.1074/jbc.r200002200
https://doi.org/10.1074/jbc.r200002200
Publikováno v:
Journal of Biological Chemistry. 276:33488-33494
Deoxyribonucleotide synthesis by anaerobic class III ribonucleotide reductases requires two proteins, NrdD and NrdG. NrdD contains catalytic and allosteric sites and, in its active form, a stable glycyl radical. This radical is generated by NrdG with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::94871402b39ad8fa918b53212386b58c
https://doi.org/10.1074/jbc.m103743200
https://doi.org/10.1074/jbc.m103743200
Publikováno v:
Journal of Biological Chemistry. 276:6185-6190
5'-Nucleotidases are the catabolic members of the substrate cycles postulated to be involved in the regulation of intracellular deoxyribonucleoside triphosphate pools. Here, we attempt to identify the nature of the nucleotidases. Earlier, we construc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8723d3755069fea83e873dc3eee5d52d
https://doi.org/10.1074/jbc.m007623200
https://doi.org/10.1074/jbc.m007623200
Autor:
Vera Bianchi, Monica Moras, Peter Reichard, Cinzia Gazziola, Paola Ferraro, Roberta Verin, Lisa Gallinaro, Chiara Rampazzo
Publikováno v:
Experimental Cell Research. 253:474-482
Human 293 cells were stably transfected with a plasmid introducing a receptor for the ecdysone analog muristerone. The cells were further stably transfected with muristerone-inducible expression vectors carrying either the cDNA for the human high K(M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7aacad22546880144769239684520cce
https://doi.org/10.1006/excr.1999.4681
https://doi.org/10.1006/excr.1999.4681
Publikováno v:
Journal of Biological Chemistry. 274:7182-7189
Three separate classes of ribonucleotide reductases are known, each with a distinct protein structure. One common feature of all enzymes is that a single protein generates each of the four deoxyribonucleotides. Class I and III enzymes contain an allo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d27cf86329f91c54c7cf236427754d2c
https://doi.org/10.1074/jbc.274.11.7182
https://doi.org/10.1074/jbc.274.11.7182