Zobrazeno 1 - 10
of 102
pro vyhledávání: '"Peter, Proks"'
Autor:
Karin E. J. Rödström, Alexander Cloake, Janina Sörmann, Agnese Baronina, Kathryn H. M. Smith, Ashley C. W. Pike, Jackie Ang, Peter Proks, Marcus Schewe, Ingelise Holland-Kaye, Simon R. Bushell, Jenna Elliott, Els Pardon, Thomas Baukrowitz, Raymond J. Owens, Simon Newstead, Jan Steyaert, Elisabeth P. Carpenter, Stephen J. Tucker
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Potassium channels of the Two-Pore Domain (K2P) subfamily, KCNK1-KCNK18, play crucial roles in controlling the electrical activity of many different cell types and represent attractive therapeutic targets. However, the identification of high
Externí odkaz:
https://doaj.org/article/9ac3923cca8e4d1e92ffe481cfd471bf
Autor:
Gregor Sachse, Elizabeth Haythorne, Peter Proks, Michelle Stewart, Heather Cater, Sian Ellard, Ben Davies, Frances M. Ashcroft
Publikováno v:
Wellcome Open Research, Vol 5 (2021)
Background: The KATP channel plays a key role in glucose homeostasis by coupling metabolically generated changes in ATP to insulin secretion from pancreatic beta-cells. Gain-of-function mutations in either the pore-forming (Kir6.2) or regulatory (SUR
Externí odkaz:
https://doaj.org/article/da5a6d9d81634ea3acf26817fe1ae241
Publikováno v:
PLoS ONE, Vol 16, Iss 10, p e0258275 (2021)
In addition to the classical voltage-dependent behavior mediated by the voltage-sensing-domains (VSD) of ion channels, a growing number of voltage-dependent gating behaviors are being described in channels that lack canonical VSDs. A common thread in
Externí odkaz:
https://doaj.org/article/e00ec64f68284455b9dbe1737546126d
Autor:
Yuko, Maejima, Shoichiro, Horita, Shoko, Yokota, Tomoyuki, Ono, Peter, Proks, Hiromi, Yoshida-Komiya, Yoichi, Ueta, Katsuhiko, Nishimori, Shingen, Misaka, Kenju, Shimomura
Publikováno v:
Journal of Food and Drug Analysis. 29:653-675
Oxytocin (Oxt) is known to regulate social communication, stress and body weight. The activation of Oxt receptors (OTR) has clinical potential to abate stress disorders and metabolic syndrome. Kamikihito (KKT) is a traditional Japanese medicine used
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::504c3bbb9316f6c2d01ba0d8caf6a7c3
https://doi.org/10.38212/2224-6614.3381
https://doi.org/10.38212/2224-6614.3381
Autor:
Janina Sörmann, Marcus Schewe, Peter Proks, Thibault Jouen-Tachoire, Shanlin Rao, Elena B. Riel, Katherine E. Agre, Amber Begtrup, John Dean, Maria Descartes, Jan Fischer, Alice Gardham, Carrie Lahner, Paul R. Mark, Srikanth Muppidi, Pavel N. Pichurin, Joseph Porrmann, Jens Schallner, Kirstin Smith, Volker Straub, Pradeep Vasudevan, Rebecca Willaert, Elisabeth P. Carpenter, Karin E. J. Rödström, Michael G. Hahn, Thomas Müller, Thomas Baukrowitz, Matthew E. Hurles, Caroline F. Wright, Stephen J. Tucker
Sleep apnea is a common disorder that represents a global public health burden. KCNK3 encodes TASK-1, a K+ channel implicated in the control of breathing, but its link with sleep apnea remains poorly understood. Here we describe a new developmental d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3de95186b04ef58aa01a12b0a5e88aa3
https://ora.ox.ac.uk/objects/uuid:9e4145cc-f7d2-4427-a681-824a5df36a17
https://ora.ox.ac.uk/objects/uuid:9e4145cc-f7d2-4427-a681-824a5df36a17
Publikováno v:
PLoS ONE, Vol 13, Iss 5, p e0197634 (2018)
Sulphonylurea drugs stimulate insulin secretion from pancreatic β-cells primarily by inhibiting ATP sensitive potassium (KATP) channels in the β-cell membrane. The effective sulphonylurea concentration at its site of action is significantly attenua
Externí odkaz:
https://doaj.org/article/a9c9cead1ead4bc3bde42dea0f80e156
Autor:
Frances M. Ashcroft, Russell Joynson, Thomas Hill, Raul Terrón-Expósito, Peter Proks, Gregor Sachse, Elizabeth Haythorne, Liz Bentley, Roger D. Cox, Stephen J. Tucker
Publikováno v:
Diabetes. 70:1145-1156
The ATP-sensitive K+ (KATP) channel controls blood glucose levels by coupling glucose metabolism to insulin secretion in pancreatic β-cells. E23K, a common polymorphism in the pore-forming KATP channel subunit (KCNJ11) gene, has been linked to incre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fc32a1fff09ce98744cb6b47e3f75177
https://doi.org/10.2337/db20-0691
https://doi.org/10.2337/db20-0691
Autor:
Peter Proks
Publikováno v:
Diabetes & Metabolism Journal, Vol 37, Iss 3, Pp 157-164 (2013)
Adenosine triphosphate (ATP)-sensitive potassium (KATP) channels in pancreatic β-cells play a crucial role in insulin secretion and glucose homeostasis. These channels are composed of two subunits: a pore-forming subunit (Kir6.2) and a regulatory su
Externí odkaz:
https://doaj.org/article/e32a4f6cd2fa4ba79611d5e24e33213a
Autor:
Matthew E. Hurles, Srikanth Muppidi, Jan Fischer, Volker Straub, Pradeep C. Vasudevan, Janina Sörmann, Maria Descartes, Joseph Porrmann, Thomas Baukrowitz, Paul R. Mark, Carrie A. Lahner, Michael G. Hahn, Pavel N. Pichurin, Alice Gardham, Marcus Schewe, Thibault R. H. Jouen-Tachoire, Caroline F. Wright, John R. Dean, Amber Begtrup, Jens Schallner, Stephen J. Tucker, Elena B. Riel, Shanlin Rao, Rebecca Willaert, Thomas Müller, Kirstin Smith, Karin E. J. Rödström, Katherine Agre, Elisabeth P. Carpenter, Peter Proks
Sleep apnea is a common disorder that represents a global public health burden.KCNK3encodes TASK-1, a K+channel implicated in the control of breathing, but its link with sleep apnea remains poorly understood. Here we describe a novel developmental di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cf1340798e7aa4606481beca7098b13a
https://doi.org/10.1101/2021.08.05.21261490
https://doi.org/10.1101/2021.08.05.21261490
In addition to the classical voltage-dependent behavior mediated by voltage-sensing-domains (VSD), a growing number of voltage-dependent gating behaviors are being described in ion channels that lack canonical VSDs. A common thread in their mechanism
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6a7d95949d4faac66418f4ff7869541e
https://doi.org/10.1101/2021.07.08.451686
https://doi.org/10.1101/2021.07.08.451686