Exosomal cargo including microRNA regulates sensory neuron to macrophage communication after nerve trauma

Autor: Raffaele Simeoli, Karli Montague, Hefin R. Jones, Laura Castaldi, David Chambers, Jayne H. Kelleher, Valentina Vacca, Thomas Pitcher, John Grist, Hadil Al-Ahdal, Liang-Fong Wong, Mauro Perretti, Johnathan Lai, Peter Mouritzen, Paul Heppenstall, Marzia Malcangio

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-17 (2017)

Exosomes are known to contain microRNAs (miRs). Here the authors show that dorsal root ganglion neurons release exosomes containing miR-21-5p, which contributes to inflammatory cell recruitment following peripheral nerve injury.

Externí odkaz: https://doaj.org/article/985f58856e554adfb658898c61646afe

Figure S1 from Clinical Implications of Monitoring Circulating Tumor DNA in Patients with Colorectal Cancer

Autor: Claus L. Andersen, Torben F. Ørntoft, Søren Laurberg, Hans J. Nielsen, Peter Mouritzen, Kim Sivesgaard, Katrine Stribolt, Anders R. Knudsen, Frank V. Mortensen, Ditte Andreasen, Philippe Lamy, Michael Knudsen, Iver Nordentoft, Søren Vang, Sigrid S. Árnadóttir, Christine G. Kassentoft, Mai-Britt W. Ørntoft, Thomas Reinert, Lone V. Schøler

Detection of ctDNA in pre-operative plasma samples according to stage.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abef2a65c9462f97dac13c6ed69c2a7d
https://doi.org/10.1158/1078-0432.22467528.v1

Data from Clinical Implications of Monitoring Circulating Tumor DNA in Patients with Colorectal Cancer

Autor: Claus L. Andersen, Torben F. Ørntoft, Søren Laurberg, Hans J. Nielsen, Peter Mouritzen, Kim Sivesgaard, Katrine Stribolt, Anders R. Knudsen, Frank V. Mortensen, Ditte Andreasen, Philippe Lamy, Michael Knudsen, Iver Nordentoft, Søren Vang, Sigrid S. Árnadóttir, Christine G. Kassentoft, Mai-Britt W. Ørntoft, Thomas Reinert, Lone V. Schøler

Purpose: We investigated whether detection of ctDNA after resection of colorectal cancer identifies the patients with the highest risk of relapse and, furthermore, whether longitudinal ctDNA analysis allows early detection of relapse and informs abou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02c60ea985aac5b77dd0e164b589d19c
https://doi.org/10.1158/1078-0432.c.6526668

Profiling of Circulating microRNAs in Prostate Cancer Reveals Diagnostic Biomarker Potential

Autor: Jacob Fredsøe, Anne K. I. Rasmussen, Peter Mouritzen, Marianne T. Bjerre, Peter Østergren, Mikkel Fode, Michael Borre, Karina D. Sørensen

Publikováno v: Diagnostics, Vol 10, Iss 4, p 188 (2020)

Early detection of prostate cancer (PC) is paramount as localized disease is generally curable, while metastatic PC is generally incurable. There is a need for improved, minimally invasive biomarkers as current diagnostic tools are inaccurate, leadin

Externí odkaz: https://doaj.org/article/7678c08bdc47405e9fa88a341113712b

Elevated miR-615-3p Expression Predicts Adverse Clinical Outcome and Promotes Proliferation and Migration of Prostate Cancer Cells

Autor: Karina Dalsgaard Sørensen, Michael Borre, Jacob Fredsøe, Hein Vincent Stroomberg, Gitte Kristensen, Helle Kristensen, Linnéa Schmidt, Martin Andreas Røder, Klaus Brasso, Anne K.I. Rasmussen, Tina Fuglsang Daugaard, Siri H. Strand, Emma B. Laursen, Søren Høyer, Peter Mouritzen

Publikováno v: Laursen, E B, Fredsøe, J, Schmidt, L, Strand, S, Kristensen, H, Ildor Rasmussen, A K, Daugaard, T F, Mouritzen, P, Høyer, S, Kristensen, G, Stroomberg, H V, Brasso, K, Røder, M A, Borre, M & Sørensen, K D 2019, ' Elevated miR-615-3p Expression Predicts Adverse Clinical Outcome and Promotes Proliferation and Migration of Prostate Cancer Cells ', The American Journal of Pathology, vol. 189, no. 12, pp. 2377-2388 . https://doi.org/10.1016/j.ajpath.2019.08.007
Laursen, E B, Fredsøe, J, Schmidt, L, Strand, S H, Kristensen, H, Rasmussen, A K I, Daugaard, T F, Mouritzen, P, Høyer, S, Kristensen, G, Stroomberg, H V, Brasso, K, Røder, M A, Borre, M & Sørensen, K D 2019, ' Elevated miR-615-3p Expression Predicts Adverse Clinical Outcome and Promotes Proliferation and Migration of Prostate Cancer Cells ', The American Journal of Pathology, vol. 189, no. 12, pp. 2377-2388 . https://doi.org/10.1016/j.ajpath.2019.08.007

miR-615-3p has previously been described as up-regulated in prostate cancer (PC) tissue samples compared with nonmalignant controls; however, its prognostic potential and functional role in PC remain largely unknown. In this study, we investigated th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75aa93fa4597a2c0838afc4de5b64f2a
https://doi.org/10.1016/j.ajpath.2019.08.007