Physical basis of the ‘magnification rule’ for standardized Immunohistochemical scoring of HER2 in breast and gastric cancer

Autor: Andreas H. Scheel, Frédérique Penault-Llorca, Wedad Hanna, Gustavo Baretton, Peter Middel, Judith Burchhardt, Manfred Hofmann, Bharat Jasani, Josef Rüschoff

Publikováno v: Diagnostic Pathology, Vol 13, Iss 1, Pp 1-7 (2018)

Abstract Background Detection of HER2/neu receptor overexpression and/or amplification is a prerequisite for efficient anti-HER2 treatment of breast and gastric carcinomas. Immunohistochemistry (IHC) of the HER2 protein is the most common screening t

Externí odkaz: https://doaj.org/article/b3325c6ae48c49bd9e0ab7a9cb8b79da

The Prognostic Value of Tyrosine Kinase SRC Expression in Locally Advanced Rectal Cancer

Autor: Thilo Sprenger, Tim Beissbarth, Felix Rühlmann, Lena-Christin Conradi, Manuel Nietert, Torsten Liersch, Kia Homayounfar, B. Michael Ghadimi, Hanibal Bohnenberger, Peter Middel, Hendrik A. Wolff

Publikováno v: Journal of Cancer

The cellular sarcoma gene (SRC) is a proto-oncogene encoding for a tyrosine kinase. SRC expression was determined in locally advanced rectal adenocarcinoma tissue from pretreatment biopsies and resection specimens. The expression level was correlated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68620e9188296a879f18d04b08672186
http://europepmc.org/articles/PMC5463438

Cold Storage Injury to Rat Small-bowel Transplants-Beneficial Effect of a Modified HTK Solution

Autor: Ingmar Lautenschläger, Tomislav Stojanovic, Herbert de Groot, Ursula Rauen, Peter Middel, Gesine Pless-Petig

Publikováno v: Transplantation. 102(10)

Background The small bowel is prone to ischemic injury during transport before transplantation, an injury that endangers the recipient patient. The small-bowel mucosal microcirculation in particular appears to be highly sensitive to injury. Current p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ff9f152a354523e94afc3797a7e02ed
https://pubmed.ncbi.nlm.nih.gov/29994982

Reproducibility of Immunohistochemical Scoring for Epidermal Growth Factor Receptor Expression in Non–Small Cell Lung Cancer: Round Robin Test

Autor: Reinhard Büttner, Anja von Heydebreck, Peter Middel, Stephan Störkel, Stephan E. Baldus, Venâncio Avancini Ferreira Alves, Ilhan Celik, Anthony W. I. Lo, Lina Carvalho, Josef Rüschoff, Włodzimierz T. Olszewski, Keith M. Kerr, Alexander Marx, Marco Volante, Ludger Fink, Wolfram Jochum, Erik Thunnissen, Ralf J. Rieker, Hans Jürgen Grote, Fritz Wrba, Fernando Lopez-Rios, Thierry Jo Molina

Publikováno v: Archives of pathology & laboratory medicine, 137(9), 1255-1261. College of American Pathologists
Ruschoff, J, Kerr, K M, Grote, H J, Middel, P, von Heydebreck, A, Alves, V A, Baldus, S E, Buttner, R, Carvalho, L, Fink, L, Jochum, W, Lo, A W I, Lopez-Rios, F, Marx, A, Molina, T J, Olszewski, W T, Rieker, R J, Volante, M, Thunnissen, E, Wrba, F, Celik, I & Storkel, S 2013, ' Reproducibility of immunohistochemical scoring for epidermal growth factor receptor expression in non-small cell lung cancer: round robin test ', Archives of pathology & laboratory medicine, vol. 137, no. 9, pp. 1255-1261 . https://doi.org/10.5858/arpa.2012-0605-OA

The addition of cetuximab to first-line chemotherapy substantially prolonged survival in patients with advanced non-small cell lung cancer whose tumors expressed high levels of epidermal growth factor receptor (EGFR; immunohistochemistry score of ≥

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8365899fb9d0c78a7f44e70e9feb09fa
https://doi.org/10.5858/arpa.2012-0605-oa

Enrichment of CD133-expressing cells in rectal cancers treated with preoperative radiochemotherapy is an independent marker for metastasis and survival

Autor: B. Michael Ghadimi, Lena-Christin Conradi, Torsten Liersch, Claus Rödel, Heinz Becker, Thilo Sprenger, Heiko Ermert, Hendrik A. Wolff, Franz Rödel, Peter Middel, Josef Rüschoff, Philipp Schüler, Tim Beissbarth, Kia Homayounfar

Publikováno v: Cancer. 119:26-35

BACKGROUND: The transmembrane glycoprotein CD133 (cluster of differentiation 133; also known as Prominin or PROM1) has been described as a potential stem cell marker in colorectal cancer and is associated with higher tumorigenic potential and resista

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6d16bff83053895c2816eaecac1f4d50
https://doi.org/10.1002/cncr.27703