Implementation and evaluation of a novel real-time multiplex assay for SARS-CoV-2: in-field learnings from a clinical microbiology laboratory

Autor: Mahendra Siwan, Malcolm Eaton, Eloise Williams, Dawn Giltrap, Benjamin P Howden, Julian Druce, Brian Chong, Bowen Zhang, Katherine Bond, Deborah A Williamson, Peter Kyriakou, Peter Calvert, Mike Catton

Publikováno v: Pathology

The unprecedented scale of testing required to effectively control the coronavirus disease (COVID-19) pandemic has necessitated urgent implementation of rapid testing in clinical microbiology laboratories. To date, there are limited data available on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71105166240dd759d1ea4b073ca293f7
https://doi.org/10.1016/j.pathol.2020.08.004

Health service impact of testing for respiratory pathogens using cartridge-based multiplex array versus molecular batch testing

Autor: Katherine Ryan, Vincent Sinickas, Vanessa Clifford, Hiu Tat Chan, Peter Kyriakou, Dawn Giltrap, Victoria M. Madigan

Publikováno v: Pathology

Summary There is increasing demand for access to rapid microbiological testing, with a view to improving clinical outcomes. The possibility of rapid testing has been facilitated by development of cartridge-based random access molecular technologies t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a8ab36e9ac85f69465bf6fcf098a57a
https://doi.org/10.1016/j.pathol.2018.08.012

Mannan-MUC1–Pulsed Dendritic Cell Immunotherapy: A Phase I Trial in Patients with Adenocarcinoma

Autor: Hui K Gan, Anne Zhao, Paul Mitchell, Vaios Karanikas, Ian F. C. McKenzie, Peter Kyriakou, Kate Hamilton, Shane White, Vasso Apostolopoulos, Bruce E. Loveland, Pei-Xiang Xing, Hilary A. Vaughan, Geoffrey A. Pietersz

Publikováno v: Clinical Cancer Research. 12:869-877

Purpose: Tumor antigen-loaded dendritic cells show promise for cancer immunotherapy. This phase I study evaluated immunization with autologous dendritic cells pulsed with mannan-MUC1 fusion protein (MFP) to treat patients with advanced malignancy. Ex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72214a310346efbc76ea3d6bf3e8c0f1
https://doi.org/10.1158/1078-0432.ccr-05-1574

The effect of d-penicillamine on metallothionein mRNA levels and copper distribution in mouse hepatocytes

Autor: David M. Danks, Andrew Grimes, Harry J McArdle, Julian F. B. Mercer, Peter Kyriakou

Publikováno v: Chemico-Biological Interactions. 75:315-324

Penicillamine increases the levels of metallothionein (MT) mRNA in a time and concentration dependent manner without altering either the rate of copper uptake or the amount of copper within the cell. The effect is dependent on the presence of intrace

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbc87e9cda70a883b9e09264762205ab
https://doi.org/10.1016/0009-2797(90)90074-w

Interaction of CD46 with measles virus: accessory role of CD46 short consensus repeat IV

Autor: Peter Kyriakou, Bruce E. Loveland, Carine Escoffier, Marc Lanteri, Dale Christiansen, Denis Gerlier

Publikováno v: Journal of General Virology
Journal of General Virology, 2000, 81 (4), pp.911-917. ⟨10.1099/0022-1317-81-4-911⟩
Journal of General Virology, Microbiology Society, 2000, 81 (4), pp.911-917. ⟨10.1099/0022-1317-81-4-911⟩

To define further the accessory role(s) of the CD46 (membrane cofactor protein) short consensus repeat (SCR) III and IV domains in the interaction of CD46 with measles virus (MV), chimeric proteins were generated by substituting domains from the stru

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8c67a8ee217c3c9de5defedf2d73c81
https://hal.science/hal-02475177