Zobrazeno 1 - 10
of 78
pro vyhledávání: '"Peter, Kosa"'
Publikováno v:
Frontiers in Neurology, Vol 15 (2024)
IntroductionIncreasing shortage of neurologists compounded by the global aging of the population have translated into suboptimal care of patients with chronic neurological diseases. While some patients might benefit from expanding telemedicine, monit
Externí odkaz:
https://doaj.org/article/9032d6d2084a4ed58e7b38249b7f15d5
Autor:
Peter Kosa, Christopher Barbour, Mihael Varosanec, Alison Wichman, Mary Sandford, Mark Greenwood, Bibiana Bielekova
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Multiple sclerosis (MS) changes the composition of the CSF. Here the authors use patient samples and aggregate CSF biomarkers into models that predict disability across all MS phenotypes, and identify potentially causal mechanisms and molecular disea
Externí odkaz:
https://doaj.org/article/135390552a0f4626ba4c30a88f0bb58c
Autor:
Ruturaj R. Masvekar, Peter Kosa, Kimberly Jin, Kerry Dobbs, Michael A. Stack, Riccardo Castagnoli, Virginia Quaresima, Helen C. Su, Luisa Imberti, Luigi D. Notarangelo, Bibiana Bielekova
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 9, Iss 5, Pp 622-632 (2022)
Abstract Objective Given the continued spread of coronavirus 2, the early predictors of coronavirus disease 19 (COVID‐19) associated mortality might improve patients' outcomes. Increased levels of circulating neurofilament light chain (NfL), a biom
Externí odkaz:
https://doaj.org/article/7b0696edb7774efab599b332deb079cd
Autor:
Erin Kelly, Mihael Varosanec, Peter Kosa, Vesna Prchkovska, David Moreno-Dominguez, Bibiana Bielekova
Publikováno v:
Frontiers in Radiology, Vol 2 (2022)
Composite MRI scales of central nervous system tissue destruction correlate stronger with clinical outcomes than their individual components in multiple sclerosis (MS) patients. Using machine learning (ML), we previously developed Combinatorial MRI s
Externí odkaz:
https://doaj.org/article/14079176d997486699c60cae8348cbbc
Publikováno v:
Frontiers in Radiology, Vol 2 (2022)
IntroductionBoth aging and multiple sclerosis (MS) cause central nervous system (CNS) atrophy. Excess brain atrophy in MS has been interpreted as “accelerated aging.” Current paper tests an alternative hypothesis: MS causes CNS atrophy by mechani
Externí odkaz:
https://doaj.org/article/8690db3b264f49ae9c294cde8261a186
Autor:
Peter Kosa, Ruturaj Masvekar, Mika Komori, Jonathan Phillips, Vighnesh Ramesh, Mihael Varosanec, Mary Sandford, Bibiana Bielekova
Publikováno v:
JCI Insight, Vol 7, Iss 15 (2022)
BACKGROUND Serum neurofilament light chain (sNFL) is becoming an important biomarker of neuro-axonal injury. Though sNFL correlates with CSF NFL (cNFL), 40% to 60% of variance remains unexplained. We aimed to mathematically adjust sNFL to strengthen
Externí odkaz:
https://doaj.org/article/c8adbf47009e449d893b779aa662c743
Publikováno v:
npj Digital Medicine, Vol 4, Iss 1, Pp 1-13 (2021)
Abstract As the burden of neurodegenerative diseases increases, time-limited clinic encounters do not allow quantification of complex neurological functions. Patient-collected digital biomarkers may remedy this, if they provide reliable information.
Externí odkaz:
https://doaj.org/article/3aff0db76c8b4145b5c4a76b8e9a85e9
Autor:
Komi S. Messan, Linh Pham, Thomas Harris, Yujin Kim, Vanessa Morgan, Peter Kosa, Bibiana Bielekova
Publikováno v:
Frontiers in Medical Technology, Vol 3 (2022)
Technological advances, lack of medical professionals, high cost of face-to-face encounters, and disasters such as the COVID-19 pandemic fuel the telemedicine revolution. Numerous smartphone apps have been developed to measure neurological functions.
Externí odkaz:
https://doaj.org/article/185c25e9cfc34502acb61cfaefb7bac9
Autor:
Kamilah Castro, Achilles Ntranos, Mario Amatruda, Maria Petracca, Peter Kosa, Emily Y. Chen, Johannes Morstein, Dirk Trauner, Corey T. Watson, Michael A. Kiebish, Bibiana Bielekova, Matilde Inglese, Ilana Katz Sand, Patrizia Casaccia
Publikováno v:
EBioMedicine, Vol 43, Iss , Pp 392-410 (2019)
Background: Multiple Sclerosis (MS) results from genetic predisposition and environmental variables, including elevated Body Mass Index (BMI) in early life. This study addresses the effect of BMI on the epigenome of monocytes and disease course in MS
Externí odkaz:
https://doaj.org/article/11212effad30432aa4a5608562002aa7
Publikováno v:
Frontiers in Neurology, Vol 11 (2020)
Quantifying cell subpopulations in biological fluids aids in diagnosis and understanding of the mechanisms of injury. Although much has been learned from cerebrospinal fluid (CSF) flow cytometry in neuroimmunological disorders, such as multiple scler
Externí odkaz:
https://doaj.org/article/9062c26711094515a9125834062e8f00