Zobrazeno 1 - 10
of 87
pro vyhledávání: '"Peter, Kolesar"'
Publikováno v:
Cells, Vol 13, Iss 10, p 812 (2024)
In the original publication [...]
Externí odkaz:
https://doaj.org/article/a1d25c6906144eab87e48379f23b7788
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
CAPPs are putative Primase-Polymerases associated with CRISPR-Cas operons. Here, the authors show CAPPs genetic and physical association with Cas1 and Cas2, their capacity to function as DNA-dependent DNA primases and DNA polymerases, and that Cas1-C
Externí odkaz:
https://doaj.org/article/efc9c689cc494105b57df2aab55a9b23
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Abstract The SMC (Structural Maintenance of Chromosomes) complexes are composed of SMC dimers, kleisin and kleisin-interacting (HAWK or KITE) subunits. Mutual interactions of these subunits constitute the basal architecture of the SMC complexes. In a
Externí odkaz:
https://doaj.org/article/c65c459f638e40849aacc4d743d98a78
Publikováno v:
Cells, Vol 11, Iss 1, p 165 (2022)
Structural Maintenance of Chromosomes (SMC) complexes are important for many aspects of the chromosomal organization. Unlike cohesin and condensin, the SMC5/6 complex contains a variant RING domain carried by its Nse1 subunit. RING domains are charac
Externí odkaz:
https://doaj.org/article/5ff87f4fac8f4fbb81378382fce627f3
Autor:
Thomas A. Guilliam, Nigel C. Brissett, Aaron Ehlinger, Benjamin A. Keen, Peter Kolesar, Elaine M. Taylor, Laura J. Bailey, Howard D. Lindsay, Walter J. Chazin, Aidan J. Doherty
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
PrimPol is a multifunctional replicative enzyme that can bypass DNA damage, as well as reprime replication restart. Here, the authors have elucidated how PrimPol is recruited to stalled replication forks via specific interactions with RPA, which stim
Externí odkaz:
https://doaj.org/article/6c3b35c0421a4ab2b8722df6acbdcac6
Autor:
Arthur W. H. Li, Katerina Zabrady, Lewis J. Bainbridge, Matej Zabrady, Sehr Naseem-Khan, Madison B. Berger, Peter Kolesar, G. Andrés Cisneros, Aidan J. Doherty
Publikováno v:
Nature
During the initiation of DNA replication, oligonucleotide primers are synthesized de novo by primases and are subsequently extended by replicative polymerases to complete genome duplication. The primase-polymerase (Prim-Pol) superfamily is a diverse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::305f2d6f7b0c71293c9847b071860c16
https://doi.org/10.1038/s41586-022-04695-0
https://doi.org/10.1038/s41586-022-04695-0
Autor:
Laura J. Bailey, Rebecca Teague, Aidan J. Doherty, Howard D. Lindsay, Lewis J Bainbridge, Peter Kolesar
Publikováno v:
Science Advances
Description
PrimPol is regulated by PLK1 phosphorylation to restrict repriming and prevent genomic instability.
Replication stress and DNA damage stall replication forks and impede genome synthesis. During S phase, damage tolerance pathways
PrimPol is regulated by PLK1 phosphorylation to restrict repriming and prevent genomic instability.
Replication stress and DNA damage stall replication forks and impede genome synthesis. During S phase, damage tolerance pathways
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b966009d07a42362160b90f9e6d66ce
http://sro.sussex.ac.uk/id/eprint/103390/3/sciadv.abh1004.pdf
http://sro.sussex.ac.uk/id/eprint/103390/3/sciadv.abh1004.pdf
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
CRISPR-Cas pathways provide prokaryotes with acquired “immunity” against foreign genetic elements, including phages and plasmids. Although many of the proteins associated with CRISPR-Cas mechanisms are characterized, some requisite enzymes remain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe0d4647995cb6a412b1b991da98b7f7
https://pubmed.ncbi.nlm.nih.gov/34140468
https://pubmed.ncbi.nlm.nih.gov/34140468
Autor:
E. Lelkes, David Potesil, S.R. Ganji, Jan Paleček, Marek Adamus, Katerina Zabrady, Zbyněk Zdráhal, Peter Kolesar
Publikováno v:
Journal of molecular biology. 432(13)
A family of Structural Maintenance of Chromosome (SMC) complexes is essential for key cellular processes ensuring proper cohesion, condensation and replication. They share a common SMC-kleisin architecture allowing them to embrace DNA. In SMC5/6, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de9dafa80d589adb06e91cf9e766ae5a
https://pubmed.ncbi.nlm.nih.gov/32389690
https://pubmed.ncbi.nlm.nih.gov/32389690
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
The SMC (Structural Maintenance of Chromosomes) complexes are composed of SMC dimers, kleisin and kleisin-interacting subunits. Mutual interactions of these subunits constitute the basal architecture of the SMC complexes. Particularly, terminal domai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::989e194713c405c0d3f091d6d80132da