Zobrazeno 1 - 10
of 117
pro vyhledávání: '"Peter, Kloppenburg"'
Development of a genetically encoded sensor for probing endogenous nociceptin opioid peptide release
Autor:
Xuehan Zhou, Carrie Stine, Patricia Oliveira Prada, Debora Fusca, Kevin Assoumou, Jan Dernic, Musadiq A. Bhat, Ananya S. Achanta, Joseph C. Johnson, Amanda Loren Pasqualini, Sanjana Jadhav, Corinna A. Bauder, Lukas Steuernagel, Luca Ravotto, Dietmar Benke, Bruno Weber, Azra Suko, Richard D. Palmiter, Miriam Stoeber, Peter Kloppenburg, Jens C. Brüning, Michael R. Bruchas, Tommaso Patriarchi
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract Nociceptin/orphanin-FQ (N/OFQ) is a recently appreciated critical opioid peptide with key regulatory functions in several central behavioral processes including motivation, stress, feeding, and sleep. The functional relevance of N/OFQ action
Externí odkaz:
https://doaj.org/article/85f93020cae0443ca2de0481924bf37c
Autor:
Tamara Sotelo-Hitschfeld, Marielle Minère, Paul Klemm, Diba Borgmann, Daria Wnuk-Lipinski, Alexander Jais, Xianglian Jia, Svenja Corneliussen, Peter Kloppenburg, Henning Fenselau, Jens Claus Brüning
Publikováno v:
Cell Reports, Vol 43, Iss 6, Pp 114343- (2024)
Summary: Activation of prepronociceptin (PNOC)-expressing neurons in the arcuate nucleus (ARC) promotes high-fat-diet (HFD)-induced hyperphagia. In turn, PNOCARC neurons can inhibit the anorexic response of proopiomelanocortin (POMC) neurons. Here, w
Externí odkaz:
https://doaj.org/article/c579a6fc73c94a7fbeb7db87ec4dec2e
Autor:
Alain De Solis, Almudena Del Rio-Martin, Jan Radermacher, Weiyi Chen, Lukas Steuernagel, Corinna Bauder, Fynn Eggersmann, Ronald Morgan, Anna-Lena Cremer, Michael Sue, Stephan Vollmar, Heiko Backes, Kamal Rahmouni, Peter Kloppenburg, Jens Brüning
Publikováno v:
IBRO Neuroscience Reports, Vol 15, Iss , Pp S757- (2023)
Externí odkaz:
https://doaj.org/article/8b61319825c84bd3885478f3050d4cde
Publikováno v:
Bio-Protocol, Vol 13, Iss 16 (2023)
Intracellular signaling pathways directly and indirectly regulate neuronal activity. In cellular electrophysiological measurements with sharp electrodes or whole-cell patch clamp recordings, there is a great risk that these signaling pathways are dis
Externí odkaz:
https://doaj.org/article/3a25f4d4f3ab4251b4e834d60e4b17cf
Autor:
Xing Xiao, Gagik Yeghiazaryan, Simon Hess, Paul Klemm, Anna Sieben, André Kleinridders, Donald A. Morgan, F. Thomas Wunderlich, Kamal Rahmouni, Dong Kong, Thomas E. Scammell, Bradford B. Lowell, Peter Kloppenburg, Jens C. Brüning, A. Christine Hausen
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
The wake-active orexin system plays a central role in the dynamic regulation of glucose homeostasis. Here the authors report that inactivation of the orexin receptor type 1 or 2 in serotonergic neurons differentially regulate systemic glucose homeost
Externí odkaz:
https://doaj.org/article/526ad1da292b4e9a9a66f3e0635380a6
Autor:
Isabella Gaziano, Svenja Corneliussen, Nasim Biglari, René Neuhaus, Linyan Shen, Tamara Sotelo-Hitschfeld, Paul Klemm, Lukas Steuernagel, Alain J. De Solis, Weiyi Chen, F. Thomas Wunderlich, Peter Kloppenburg, Jens C. Brüning
Publikováno v:
JCI Insight, Vol 7, Iss 21 (2022)
Dopamine acts on neurons in the arcuate nucleus (ARC) of the hypothalamus, which controls homeostatic feeding responses. Here we demonstrate a differential enrichment of dopamine receptor 1 (Drd1) expression in food intake–promoting agouti related
Externí odkaz:
https://doaj.org/article/04d46d9f4e164c19a1ca885f921b9383
Autor:
Anita Siller, Nadja T Hofer, Giulia Tomagra, Nicole Burkert, Simon Hess, Julia Benkert, Aisylu Gaifullina, Desiree Spaich, Johanna Duda, Christina Poetschke, Kristina Vilusic, Eva Maria Fritz, Toni Schneider, Peter Kloppenburg, Birgit Liss, Valentina Carabelli, Emilio Carbone, Nadine Jasmin Ortner, Jörg Striessnig
Publikováno v:
eLife, Vol 11 (2022)
In dopaminergic (DA) Substantia nigra (SN) neurons Cav2.3 R-type Ca2+-currents contribute to somatodendritic Ca2+-oscillations. This activity may contribute to the selective degeneration of these neurons in Parkinson’s disease (PD) since Cav2.3-kno
Externí odkaz:
https://doaj.org/article/9faa676ef6d24167b54187fd03cc356d
Publikováno v:
Data in Brief, Vol 39, Iss , Pp 107494- (2021)
Multiple processes shape calcium signals in neurons. The spatial and temporal dynamics of these signals are determined by various cellular parameters, including the calcium influx, calcium buffering, and calcium extrusion. The different Ca2+ handling
Externí odkaz:
https://doaj.org/article/66983fbcb26f4fa5b38cdd6b29659445
Autor:
Debora Fusca, Peter Kloppenburg
Publikováno v:
eLife, Vol 10 (2021)
Local interneurons (LNs) mediate complex interactions within the antennal lobe, the primary olfactory system of insects, and the functional analog of the vertebrate olfactory bulb. In the cockroach Periplaneta americana, as in other insects, several
Externí odkaz:
https://doaj.org/article/fdff8d6475f84ac3a8c65382d5eef31e
Autor:
Julia Benkert, Simon Hess, Shoumik Roy, Dayne Beccano-Kelly, Nicole Wiederspohn, Johanna Duda, Carsten Simons, Komal Patil, Aisylu Gaifullina, Nadja Mannal, Elena Dragicevic, Desirée Spaich, Sonja Müller, Julia Nemeth, Helene Hollmann, Nora Deuter, Yassine Mousba, Christian Kubisch, Christina Poetschke, Joerg Striessnig, Olaf Pongs, Toni Schneider, Richard Wade-Martins, Sandip Patel, Rosanna Parlato, Tobias Frank, Peter Kloppenburg, Birgit Liss
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Voltage-gated Ca2+ channels are thought to contribute to neurodegeneration of dopaminergic neurons. Here the authors find that the R-type channel Cav2.3 in substantia nigra dopaminergic neurons may contribute to neurodegeneration in a model of Parkin
Externí odkaz:
https://doaj.org/article/8271fb3221094175818e53f6966e1e51