Zobrazeno 1 - 10
of 281
pro vyhledávání: '"Peter, Kleinebudde"'
Publikováno v:
International Journal of Pharmaceutics: X, Vol 8, Iss , Pp 100303- (2024)
Elastic recovery (ER) has been investigated and discussed extensively in the field of tableting. However, until now only limited data is available regarding ER in roll compaction. Therefore, a previously established in-line measurement technique was
Externí odkaz:
https://doaj.org/article/4bcf447028244348bdb3f21fd6019384
Publikováno v:
International Journal of Pharmaceutics: X, Vol 8, Iss , Pp 100273- (2024)
Twin-screw wet granulation (TSG) is a continuous manufacturing technique either for granules as final dosage form or as an intermediate before tableting or capsule filling. A comprehensive process understanding is required to implement TSG, consideri
Externí odkaz:
https://doaj.org/article/b9981eeadcf24aeb9f8f147468933ad5
Autor:
Prince Bawuah, Mike Evans, Ard Lura, Daniel J. Farrell, Patrick J. Barrie, Peter Kleinebudde, Daniel Markl, J. Axel Zeitler
Publikováno v:
International Journal of Pharmaceutics: X, Vol 5, Iss , Pp 100186- (2023)
Fully automated at-line terahertz time-domain spectroscopy in transmission mode is used to measure tablet porosity for thousands of immediate release tablets. The measurements are rapid and non-destructive. Both laboratory prepared tablets and commer
Externí odkaz:
https://doaj.org/article/8f9989308d494dcf80b7a71bb5279f75
Publikováno v:
Pharmaceutics, Vol 14, Iss 11, p 2399 (2022)
Influence of the roll speed (RS) during roll compaction on ribbon, granule, tablet properties and its effect on the prediction of the ribbon solid fraction at-gap is often neglected or controversially discussed. The aim of this study was to investiga
Externí odkaz:
https://doaj.org/article/a3d6476a4a514a849d4cac0500a31f30
Autor:
Jerome Hansen, Peter Kleinebudde
Publikováno v:
Pharmaceutics, Vol 14, Iss 6, p 1227 (2022)
Quasi-emulsion solvent diffusion (QESD) crystallizations can improve the micromeritic properties of drugs and excipients. A solution is dispersed in a miscible antisolvent as a transient emulsion. Using this technique, substances that normally crysta
Externí odkaz:
https://doaj.org/article/17b3d22e96de4022936f9cce103ea3a4
Autor:
Annika Wilms, Peter Kleinebudde
Publikováno v:
International Journal of Pharmaceutics: X, Vol 2, Iss , Pp 100059- (2020)
A key quality attribute for solid oral dosage forms is their hardness and ability to withstand breaking or grinding. If the product is to be manufactured continuously, it can be of interest to monitor the hardness of the material at different stages
Externí odkaz:
https://doaj.org/article/24126bd67a2943d3b1edd7b9105b4477
Publikováno v:
International Journal of Pharmaceutics: X, Vol 2, Iss , Pp 100061- (2020)
Mini-tablets are solid dosage forms with increasing interest for pharmaceutical industry due to clinical and biopharmaceutical benefits. But technological aspects on mini-tableting are not fully investigated. Therefore, the impact of punch size and t
Externí odkaz:
https://doaj.org/article/624529f61c544dcb9be5ff2c5aa5cd09
Publikováno v:
International Journal of Pharmaceutics: X, Vol 1, Iss , Pp - (2019)
The granule size distribution is a critical quality attribute of granules. It has a great impact on further packaging or processing. Due to increasing interest in continuous manufacturing techniques, it is of high interest to develop an in-line or on
Externí odkaz:
https://doaj.org/article/c72779818c064cdc985a04c3e8b986bd
Autor:
Peter Toson, Diogo G. Lopes, Raphael Paus, Ashish Kumar, Jeroen Geens, Sandy Stibale, Julian Quodbach, Peter Kleinebudde, Wen-Kai Hsiao, Johannes Khinast
Publikováno v:
International Journal of Pharmaceutics: X, Vol 1, Iss , Pp - (2019)
This work presents a new model based approach to process design and scale-up within the same equipment of a roller compaction process. The prediction of the operating space is not performed fully in-silico, but uses low-throughput experiments as inpu
Externí odkaz:
https://doaj.org/article/dfd576819c1341e6aa81340b5843143e
Autor:
Sebastian Bollmann, Peter Kleinebudde
Publikováno v:
Pharmaceutics, Vol 13, Iss 9, p 1488 (2021)
In silico tools which predict the dissolution of pharmaceutical dosage forms using virtual matrices can be validated with virtual matrices based on X-ray micro-computed tomography images of real pharmaceutical formulations. Final processed images of
Externí odkaz:
https://doaj.org/article/caaae93e8854422089e53741531cb3f3