Výsledky vyhledávání - "Peter, Houghton"

Akademický článek

Whole genome and reverse protein phase array landscapes of patient derived osteosarcoma xenograft models

Autor: Chia-Chin Wu, Licai Huang, Zhongting Zhang, Zhenlin Ju, Xingzhi Song, E. Anders Kolb, Wendong Zhang, Jonathan Gill, Min Ha, Malcolm A. Smith, Peter Houghton, Christopher L. Morton, Raushan Kurmasheva, John Maris, Yael Mosse, Yiling Lu, Richard Gorlick, P. Andrew Futreal, Hannah C. Beird

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)

Abstract Osteosarcoma is the most common primary bone malignancy in children and young adults, and it has few treatment options. As a result, there has been little improvement in survival outcomes in the past few decades. The need for models to test

Externí odkaz: https://doaj.org/article/f8e627346ea440b7a5955c5d78e43866

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Akademický článek

Defining function of wild-type and three patient-specific TP53 mutations in a zebrafish model of embryonal rhabdomyosarcoma

Publikováno v: eLife, Vol 12 (2023)

In embryonal rhabdomyosarcoma (ERMS) and generally in sarcomas, the role of wild-type and loss- or gain-of-function TP53 mutations remains largely undefined. Eliminating mutant or restoring wild-type p53 is challenging; nevertheless, understanding p5

Externí odkaz: https://doaj.org/article/869c09202a0d4108bb57d631b09af023

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Akademický článek

Interaction between SNAI2 and MYOD enhances oncogenesis and suppresses differentiation in Fusion Negative Rhabdomyosarcoma

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)

Rhabdomyosarcomas are tumours blocked in myogenic differentiation, which despite the expression of master muscle regulatory factors, including MYOD, are unable to differentiate. Here, the authors show that SNAI2 is upregulated by MYOD through super e

Externí odkaz: https://doaj.org/article/13792164b2674112a670f2c8b5793e7e

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Akademický článek

Age-associated genes in human mammary gland drive human breast cancer progression

Autor: Xiang Gu, Bingzhi Wang, Haiyan Zhu, You Zhou, Aaron M. Horning, Tim H-M Huang, Yidong Chen, Peter Houghton, Zhao Lai, Joel E. Michalek, Lu-Zhe Sun

Publikováno v: Breast Cancer Research, Vol 22, Iss 1, Pp 1-15 (2020)

Abstract Background Aging is a comorbidity of breast cancer suggesting that aging-associated transcriptome changes may promote breast cancer progression. However, the mechanism underlying the age effect on breast cancer remains poorly understood. Met

Externí odkaz: https://doaj.org/article/437e4e0e08814325a16b27c396b42ce4

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Akademický článek

MiR-584-5p potentiates vincristine and radiation response by inducing spindle defects and DNA damage in medulloblastoma

Autor: Nourhan Abdelfattah, Subapriya Rajamanickam, Subbarayalu Panneerdoss, Santosh Timilsina, Pooja Yadav, Benjamin C. Onyeagucha, Michael Garcia, Ratna Vadlamudi, Yidong Chen, Andrew Brenner, Peter Houghton, Manjeet K. Rao

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-19 (2018)

The radiation and chemotherapy used for treating medulloblastoma patients cause debilitating side effects. Here, the authors show that miR-584 acts as a therapeutic adjuvant as it sensitizes medulloblastoma to radiation and chemotherapy by targeting

Externí odkaz: https://doaj.org/article/7e6b817f247d44dd9e1ce5001fd43f4d

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Akademický článek

73565 Defining tp53 tumor suppressor functions in zebrafish embryonal rhabdomyosarcoma

Autor: Kunal Baxi, Jiangfei Chen, Amanda Lipsitt, Nicole Hensch, Long Wang, Abhik Bandopadhyay, Aaron Sugalski, Andrea Gilbert, Eleanor Chen, Peter Houghton, Gail Tomlinson, Myron Ignatius

Publikováno v: Journal of Clinical and Translational Science, Vol 5, Pp 19-20 (2021)

ABSTRACT IMPACT: By assessing function of mutant (patient-specific) tp53 in zebrafish embryonal rhabdomyosarcoma will inform clinicians of the severity of mutant tp53 alleles. OBJECTIVES/GOALS: This study aims to define loss- and gain-of-function TP5

Externí odkaz: https://doaj.org/article/746745541b8e4723853ee28927b8c2b3

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Akademický článek

Emerging novel agents for patients with advanced Ewing sarcoma: a report from the Children’s Oncology Group (COG) New Agents for Ewing Sarcoma Task Force [version 1; peer review: 3 approved]

Autor: Kelly Bailey, Carrye Cost, Ian Davis, Julia Glade-Bender, Patrick Grohar, Peter Houghton, Michael Isakoff, Elizabeth Stewart, Nadia Laack, Jason Yustein, Damon Reed, Katherine Janeway, Richard Gorlick, Stephen Lessnick, Steven DuBois, Pooja Hingorani

Publikováno v: F1000Research, Vol 8 (2019)

Ewing sarcoma is a small round blue cell malignancy arising from bone or soft tissue and most commonly affects adolescents and young adults. Metastatic and relapsed Ewing sarcoma have poor outcomes and recurrences remain common. Owing to the poor out

Externí odkaz: https://doaj.org/article/443fdb2786094b91af779ecb997a6867

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