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pro vyhledávání: '"Peter, Hlavica"'
Autor:
Peter Hlavica
Publikováno v:
Journal of Inorganic Biochemistry. 241:112150
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2863b3a91a9322a91b4efa9e17ddef8b
https://doi.org/10.1016/j.jinorgbio.2023.112150
https://doi.org/10.1016/j.jinorgbio.2023.112150
Autor:
Peter Hlavica
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 1834:205-220
Fungi belong to the large kingdom of lower eukaryotic organisms encompassing yeasts along with filamentous and dimorphic members. Microbial P450 enzymes have contributed to exploration of and adaptation to diverse ecological niches such as conversion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40280bdef39f1f67326223cbe281f444
https://doi.org/10.1016/j.bbapap.2012.09.012
https://doi.org/10.1016/j.bbapap.2012.09.012
Autor:
Peter Hlavica
Publikováno v:
Journal of inorganic biochemistry. 167
Cytochrome P450s (CYP) represent a superfamily of b -type hemoproteins catalyzing NAD(P)H-dependent oxidative biotransformation of a vast array of natural and xenobiotic compounds. Many eu- and prokaryotic members of this class of monooxygenases disp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cdef46a38cb50c8a9274ed62813db09
https://pubmed.ncbi.nlm.nih.gov/27919007
https://pubmed.ncbi.nlm.nih.gov/27919007
Autor:
Peter Hlavica
Publikováno v:
Journal of Inorganic Biochemistry. 105:1354-1364
Among eukaryotic P450s, the greatest expansion has been in insects, providing useful model systems for the study of enzyme evolution in response to natural and anthropogenic pressures such as the chemical warfare against plant toxins and synthetic in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6653664249b933be30c1bbaf45476aae
https://doi.org/10.1016/j.jinorgbio.2011.05.003
https://doi.org/10.1016/j.jinorgbio.2011.05.003
Autor:
Michael Lehnerer, Peter Hlavica
Publikováno v:
Current Drug Metabolism. 11:85-104
In view of the pivotal role played by the diversity of fatty acid-derived oxy-products in a vast array of physiological processes, precise knowledge about the molecular principles dictating substrate specificity and regioselectivity in P450-catalyzed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::100500ce7b81be966a83cd1acaaf4309
https://doi.org/10.2174/138920010791110881
https://doi.org/10.2174/138920010791110881
Autor:
Peter Hlavica
Publikováno v:
Biotechnology Advances. 27:103-121
The high plasticity of the active-site cavity of cytochromes P450, permitting reactivity toward a vast array of compounds, makes these enzymes attractive targets for biotechnological application. Escalating attention in this area is driven by remarka
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfd8b13298982222ae1adbd81d23dcc1
https://doi.org/10.1016/j.biotechadv.2008.10.001
https://doi.org/10.1016/j.biotechadv.2008.10.001
Autor:
Peter, Hlavica
Publikováno v:
Advances in experimental medicine and biology. 851
Cytochromes P450 (P450s) are hemoproteins catalyzing oxidative biotransformation of a vast array of natural and xenobiotic compounds. Reducing equivalents required for dioxygen cleavage and substrate hydroxylation originate from different redox partn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ec4282a0efa221171fa59246ac054a13
https://pubmed.ncbi.nlm.nih.gov/26002739
https://pubmed.ncbi.nlm.nih.gov/26002739
Autor:
Peter Hlavica
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 1764:645-670
The widespread use of nitrogenous organic bases as environmental chemicals, food additives, and clinically important drugs necessitates precise knowledge about the molecular principles governing biotransformation of this category of substrates. In th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b830d05619fd2790b8a86f82ff7f7eff
https://doi.org/10.1016/j.bbapap.2006.01.013
https://doi.org/10.1016/j.bbapap.2006.01.013
Autor:
Peter Hlavica
Publikováno v:
Advances in Experimental Medicine and Biology ISBN: 9783319160085
Cytochromes P450 (P450s) are hemoproteins catalyzing oxidative biotransformation of a vast array of natural and xenobiotic compounds. Reducing equivalents required for dioxygen cleavage and substrate hydroxylation originate from different redox partn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::682a6688aad964f15262c8b114181c0a
https://doi.org/10.1007/978-3-319-16009-2_10
https://doi.org/10.1007/978-3-319-16009-2_10
Autor:
Peter Hlavica
Publikováno v:
Drug Metabolism Reviews. 34:451-477
Indirect evidence for the participation of cytochrome P450 (P450) in the microsomal N-oxygenation of primary and N-substituted amine functions is presented by studies employing diagnostic modifiers of the hemoprotein system as well as immunochemical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::457ef1e55642d97b90aaaa777a6c2134
https://doi.org/10.1081/dmr-120005646
https://doi.org/10.1081/dmr-120005646