Zobrazeno 1 - 10
of 171
pro vyhledávání: '"Peter, Grimm"'
Autor:
Hans Peter Grimm, Vanessa Schumacher, Martin Schäfer, Sabine Imhof-Jung, Per-Ola Freskgård, Kevin Brady, Carsten Hofmann, Petra Rüger, Tilman Schlothauer, Ulrich Göpfert, Maximilian Hartl, Sylvia Rottach, Adrian Zwick, Shanon Seger, Rachel Neff, Jens Niewoehner, Niels Janssen
Publikováno v:
mAbs, Vol 15, Iss 1 (2023)
ABSTRACTThere are few treatments that slow neurodegeneration in Alzheimer’s disease (AD), and while therapeutic antibodies are being investigated in clinical trials for AD treatment, their access to the central nervous system is restricted by the b
Externí odkaz:
https://doaj.org/article/1e3d18094e0b44a99ca3a99a2f9d46b6
Autor:
Linnea C. Franssen, Maciej J. Swat, Andrzej M. Kierzek, Rachel H. Rose, Piet H. van derGraaf, Hans Peter Grimm
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 12, Iss 2, Pp 139-143 (2023)
Abstract Immunogenicity against therapeutic proteins frequently causes attrition owing to its potential impact on pharmacokinetics, pharmacodynamics, efficacy, and safety. Predicting immunogenicity is complex because of its multifactorial drivers, in
Externí odkaz:
https://doaj.org/article/0b455ac83df04d72a28167efc170f4e1
Autor:
Roxana Aldea, Hans Peter Grimm, Ronald Gieschke, Carsten Hofmann, Dominik Lott, Szofia Bullain, Paul Delmar, Gregory Klein, Marco Lyons, Fabrizio Piazza, Roxana O. Carare, Norman A. Mazer
Publikováno v:
Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol 8, Iss 1, Pp n/a-n/a (2022)
Abstract Introduction Amyloid‐related imaging abnormalities with edema/effusion (ARIA‐E) are commonly observed with anti‐amyloid therapies in Alzheimer's disease. We developed a semi‐mechanistic, in silico model to understand the time course
Externí odkaz:
https://doaj.org/article/0b614bdc96e645a1b1ef006dde12af9c
Autor:
Peter Obel Otto, Martina K. Loft, Peter Grimm, Søren Rafael Rafaelsen, Malene Roland V. Pedersen
Publikováno v:
European Journal of Radiology Open, Vol 8, Iss , Pp 100376- (2021)
Primary leiomyosarcoma of the colon mesentery is an extremely rare neoplasm, and only a small number of cases have been reported. We describe a case of leiomyosarcoma originating in the colonic mesentery, in a 68-year-old woman. Ultrasound showed a h
Externí odkaz:
https://doaj.org/article/7c90bbaa563b432dbe39c8c1869aa3a9
Autor:
Miro Julian Eigenmann, Tine Veronica Karlsen, Marek Wagner, Olav Tenstad, Tina Weinzierl, Tanja Fauti, Hans Peter Grimm, Trude Skogstrand, Christian Klein, Johannes Sam, Pablo Umana, Marina Bacac, Helge Wiig, Antje-Christine Walz
Publikováno v:
Pharmaceutics, Vol 13, Iss 12, p 2105 (2021)
The goal of this study is to investigate the pharmacokinetics in plasma and tumour interstitial fluid of two T-cell bispecifics (TCBs) with different binding affinities to the tumour target and to assess the subsequent cytokine release in a tumour-be
Externí odkaz:
https://doaj.org/article/a979047dc57b4cbf83485bdec1ad1621
Autor:
Volker Teichgräber, Pavel Pisa, Alex Phipps, Jean Eric Charoin, Jean Tessier, Christian Klein, Stefan Evers, Jehad Charo, Hans Peter Grimm, Tapan Nayak, Christophe Boetsch, Benjamin Ribba
Supplemental legend
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a35ccf90ebb95538b3b96ffdcec280c
https://doi.org/10.1158/1078-0432.22465131.v1
https://doi.org/10.1158/1078-0432.22465131.v1
Autor:
Marina Bacac, Christian Gerdes, Pablo Umana, Christian Klein, Markus Rudin, Szymon Stoma, Jörg Zielonka, Anne Freimoser-Grundschober, Teilo Schaller, Linda Fahrni, Tanja Fauti, Sara Colombetti, Johannes Sam, Hans-Peter Grimm, Ramanil Perera, Steffi Lehmann
Supplementary Methods and Figure Legends.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::575b652a7c3a4cc1f4a4120f33b42e6b
https://doi.org/10.1158/1078-0432.22458585.v1
https://doi.org/10.1158/1078-0432.22458585.v1
Autor:
Marina Bacac, Christian Gerdes, Pablo Umana, Christian Klein, Markus Rudin, Szymon Stoma, Jörg Zielonka, Anne Freimoser-Grundschober, Teilo Schaller, Linda Fahrni, Tanja Fauti, Sara Colombetti, Johannes Sam, Hans-Peter Grimm, Ramanil Perera, Steffi Lehmann
Purpose: CEA TCB (RG7802, RO6958688) is a novel T-cell bispecific antibody, engaging CD3ϵ upon binding to carcinoembryonic antigen (CEA) on tumor cells. Containing an engineered Fc region, conferring an extended blood half-life while preventing side
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::282e31f78b9c3a54cc232548148aa81d
https://doi.org/10.1158/1078-0432.c.6523992
https://doi.org/10.1158/1078-0432.c.6523992
Autor:
Marina Bacac, Christian Gerdes, Pablo Umana, Christian Klein, Markus Rudin, Szymon Stoma, Jörg Zielonka, Anne Freimoser-Grundschober, Teilo Schaller, Linda Fahrni, Tanja Fauti, Sara Colombetti, Johannes Sam, Hans-Peter Grimm, Ramanil Perera, Steffi Lehmann
In vitro live cell confocal imaging of LS174T RFP cells co-cultured with CFSE-labeled T-cells (E:T = 3:1) in the presence of CEA or a control TCB, respectively.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20ebe1331a20f2b3c35ab98751963a63
https://doi.org/10.1158/1078-0432.22458582.v1
https://doi.org/10.1158/1078-0432.22458582.v1
Autor:
Marina Bacac, Christian Gerdes, Pablo Umana, Christian Klein, Markus Rudin, Szymon Stoma, Jörg Zielonka, Anne Freimoser-Grundschober, Teilo Schaller, Linda Fahrni, Tanja Fauti, Sara Colombetti, Johannes Sam, Hans-Peter Grimm, Ramanil Perera, Steffi Lehmann
Supplementary Figure S1. CEA TCB leads stimulates the expression of CD25, a T-cell activation marker, on both T-helper (CD4+) and cytotoxic T-cells (CD8+) after incubation with LS174T tumor cells. Supplementary Figure S2. CEA TCB induces efficient MK
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18733e4175bd0a2bf64931d79e4cff70
https://doi.org/10.1158/1078-0432.22458588.v1
https://doi.org/10.1158/1078-0432.22458588.v1