Zobrazeno 1 - 10
of 290
pro vyhledávání: '"Peter, Fraser"'
Autor:
Ioana Olan, Masami Ando-Kuri, Aled J. Parry, Tetsuya Handa, Stefan Schoenfelder, Peter Fraser, Yasuyuki Ohkawa, Hiroshi Kimura, Masako Narita, Masashi Narita
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract HMGA1 is an abundant non-histone chromatin protein that has been implicated in embryonic development, cancer, and cellular senescence, but its specific role remains elusive. Here, we combine functional genomics approaches with graph theory t
Externí odkaz:
https://doaj.org/article/7476e4a7107d49bfbd49a2a4b2b12352
Autor:
François Serra, Andrea Nieto-Aliseda, Lucía Fanlo-Escudero, Llorenç Rovirosa, Mónica Cabrera-Pasadas, Aleksey Lazarenkov, Blanca Urmeneta, Alvaro Alcalde-Merino, Emanuele M. Nola, Andrei L. Okorokov, Peter Fraser, Mariona Graupera, Sandra D. Castillo, Jose L. Sardina, Alfonso Valencia, Biola M. Javierre
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Activation of the p53 tumor suppressor triggers a transcriptional program to control cellular response to stress. However, the molecular mechanisms by which p53 controls gene transcription are not completely understood. Here, we uncover the
Externí odkaz:
https://doaj.org/article/0a358ee1ea5c43e4a2c5658e8409ffd6
Publikováno v:
BMC Biology, Vol 21, Iss 1, Pp 1-18 (2023)
Abstract Background Long-range interactions between promoters and cis-regulatory elements, such as enhancers, play critical roles in gene regulation. However, the role of three-dimensional (3D) chromatin structure in orchestrating changes in transcri
Externí odkaz:
https://doaj.org/article/8e7b8f44371a47dd947503c7a54a2bac
Autor:
Nimrod Rappoport, Elad Chomsky, Takashi Nagano, Charlie Seibert, Yaniv Lubling, Yael Baran, Aviezer Lifshitz, Wing Leung, Zohar Mukamel, Ron Shamir, Peter Fraser, Amos Tanay
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Embryonic development involves massive proliferation and differentiation of cell lineages. This must be supported by chromosome replication and epigenetic reprogramming, but how proliferation and cell fate acquisition are balanced in this pr
Externí odkaz:
https://doaj.org/article/9405487864e141ed95c600dc5cb8ef6e
Autor:
Olga Mielczarek, Carolyn H. Rogers, Yinxiu Zhan, Louise S. Matheson, Michael J.T. Stubbington, Stefan Schoenfelder, Daniel J. Bolland, Biola M. Javierre, Steven W. Wingett, Csilla Várnai, Anne Segonds-Pichon, Simon J. Conn, Felix Krueger, Simon Andrews, Peter Fraser, Luca Giorgetti, Anne E. Corcoran
Publikováno v:
Cell Reports, Vol 42, Iss 9, Pp 113074- (2023)
Summary: To produce a diverse antibody repertoire, immunoglobulin heavy-chain (Igh) loci undergo large-scale alterations in structure to facilitate juxtaposition and recombination of spatially separated variable (VH), diversity (DH), and joining (JH)
Externí odkaz:
https://doaj.org/article/125cbc8ecfba40ce99ab9245a423021d
Autor:
Danielle H. Oh, Xiao MA, Jackson He, Conor Kearney, Simon J. Hogg, Andrea Newbold, Peter Fraser, Ian G. Jennings, Daniella Brasacchio, Olivia Susanto, Chun Yew Fong, Mark A. Dawson, Emily Gruber, Lev Kats, Ricky W. Johnstone, Philip E. Thompson, Jake Shortt
Publikováno v:
HemaSphere, Vol 7, p e4369469 (2023)
Externí odkaz:
https://doaj.org/article/93d888a242994fae978e83427bf5bb01
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Genome sequencing has revealed over 300 million genetic variations in human populations. Over 90% of variants are single nucleotide polymorphisms (SNPs), the remainder include short deletions or insertions, and small numbers of structural variants. H
Externí odkaz:
https://doaj.org/article/a1a0157e13b7444a9022c9b749de2d9a
Autor:
Mayra Furlan-Magaril, Masami Ando-Kuri, Rodrigo G. Arzate-Mejía, Jörg Morf, Jonathan Cairns, Abraham Román-Figueroa, Luis Tenorio-Hernández, A. César Poot-Hernández, Simon Andrews, Csilla Várnai, Boo Virk, Steven W. Wingett, Peter Fraser
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-27 (2021)
Abstract Background Circadian gene expression is essential for organisms to adjust their physiology and anticipate daily changes in the environment. The molecular mechanisms controlling circadian gene transcription are still under investigation. In p
Externí odkaz:
https://doaj.org/article/9a210e18686b41e2bfd4786eebcb2e8a