Zobrazeno 1 - 10
of 127
pro vyhledávání: '"Peter, Fedoročko"'
Autor:
Viktória Buľková, Jana Vargová, Marián Babinčák, Rastislav Jendželovský, Zbyněk Zdráhal, Pavel Roudnický, Ján Košuth, Peter Fedoročko
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 163, Iss , Pp 114829- (2023)
The presence of key hypoxia regulators, namely, hypoxia-inducible factor (HIF)-1α or HIF-2α, in tumors is associated with poor patient prognosis. Hypoxia massively activates several genes, including the one encoding the BCRP transporter that proffe
Externí odkaz:
https://doaj.org/article/19987f68c8654c6486eade0e3a6e5a2f
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 109, Iss , Pp 2173-2181 (2019)
Breast cancer resistance protein (BCRP) belongs to the family of ATP-binding cassette (ABC) transporters, overexpression of which can confer a multidrug-resistant phenotype in cancer cells and tumors. BCRP mediates efflux of numerous xenobiotics, inc
Externí odkaz:
https://doaj.org/article/eac53d45a83a4b4c92aaf84e0d02762a
Publikováno v:
Pharmaceutics, Vol 14, Iss 5, p 1075 (2022)
It is more than sixty years since the era of modern photodynamic therapy (PDT) for cancer began. Enhanced selectivity for malignant cells with a reduced selectivity for non-malignant cells and good biocompatibility along with the limited occurrence o
Externí odkaz:
https://doaj.org/article/e63aa1a21ecf4a61a249e5e97710d241
Autor:
Mária Vilková, Monika Hudáčová, Nikola Palušeková, Rastislav Jendželovský, Miroslav Almáši, Tibor Béres, Peter Fedoročko, Mária Kožurková
Publikováno v:
Molecules, Vol 27, Iss 9, p 2883 (2022)
A series of novel acridine N-acylhydrazone derivatives have been synthesized as potential topoisomerase I/II inhibitors, and their binding (calf thymus DNA—ctDNA and human serum albumin—HSA) and biological activities as potential anticancer agent
Externí odkaz:
https://doaj.org/article/932a9bc5dce349ac90117b51b1de90d1
Autor:
Andrea Halaburková, Rastislav Jendželovský, Ján Kovaľ, Zdenko Herceg, Peter Fedoročko, Akram Ghantous
Publikováno v:
Clinical Epigenetics, Vol 9, Iss 1, Pp 1-16 (2017)
Abstract Background Hypericin-mediated photodynamic therapy (HY-PDT) has recently captured increased attention as an alternative minimally invasive anticancer treatment, although cancer cells may acquire resistance. Therefore, combination treatments
Externí odkaz:
https://doaj.org/article/0740fe4e26644ce4843521bd12441fcd
Autor:
Monika Hudáčová, Slávka Hamuľaková, Eva Konkoľová, Rastislav Jendželovský, Jana Vargová, Juraj Ševc, Peter Fedoročko, Ondrej Soukup, Jana Janočková, Veronika Ihnatova, Tomáš Kučera, Petr Bzonek, Nikola Novakova, Daniel Jun, Lucie Junova, Jan Korábečný, Kamil Kuča, Mária Kožurková
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 8, p 3830 (2021)
A series of novel C4-C7-tethered biscoumarin derivatives (12a–e) linked through piperazine moiety was designed, synthesized, and evaluated biological/therapeutic potential. Biscoumarin 12d was found to be the most effective inhibitor of both acetyl
Externí odkaz:
https://doaj.org/article/8c388bb7284d4588979e48d7f965924d
Autor:
Eva Konkoľová, Monika Hudáčová, Slávka Hamuľaková, Rastislav Jendželovský, Jana Vargová, Juraj Ševc, Peter Fedoročko, Mária Kožurková
Publikováno v:
Molecules, Vol 26, Iss 4, p 1133 (2021)
A549 human lung carcinoma cell lines were treated with a series of new drugs with both tacrine and coumarin pharmacophores (derivatives 1a–2c) in order to test the compounds’ ability to inhibit both cancer cell growth and topoisomerase I and II a
Externí odkaz:
https://doaj.org/article/0af2efc10a534d30b4ed3b66d04503a4
Autor:
Martin Majerník, Rastislav Jendželovský, Marián Babinčák, Ján Košuth, Juraj Ševc, Zuzana Tonelli Gombalová, Zuzana Jendželovská, Monika Buríková, Peter Fedoročko
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 12, p 3004 (2019)
Photodynamic therapy with hypericin (HY-PDT) and hyperforin (HP) could be treatment modalities for colorectal cancer (CRC), but evidence of their effect on angiogenic factors in CRC is missing. Convenient experimental model utilization is essential f
Externí odkaz:
https://doaj.org/article/a10c25120deb4b28b8709c2bf29a3819
Autor:
Mária, Vilková, Monika, Hudáčová, Nikola, Palušeková, Rastislav, Jendželovský, Miroslav, Almáši, Tibor, Béres, Peter, Fedoročko, Mária, Kožurková
Publikováno v:
Molecules (Basel, Switzerland). 27(9)
A series of novel acridine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::826e647382f70594d50175fcc03f2429
https://pubmed.ncbi.nlm.nih.gov/35566236
https://pubmed.ncbi.nlm.nih.gov/35566236
Publikováno v:
Pharmaceuticals, Vol 4, Iss 11, Pp 1488-1502 (2011)
In this study we have focused on the response of SKBR-3 cells to both single 17-DMAG treatment as well as its combination with photodynamic therapy with hypericin. Low concentrations of 17-DMAG without any effect on survival of SKBR-3 cells significa
Externí odkaz:
https://doaj.org/article/1f0624eceb354cdba01aea3f5584d5f0