Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Peter, De Rijk"'
Autor:
Charlotte Cautereels, Jolien Smets, Peter Bircham, Dries De Ruysscher, Anna Zimmermann, Peter De Rijk, Jan Steensels, Anton Gorkovskiy, Joleen Masschelein, Kevin J. Verstrepen
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Microbes are increasingly employed as cell factories to produce biomolecules. This often involves the expression of complex heterologous biosynthesis pathways in host strains. Achieving maximal product yields and avoiding build-up of (toxic)
Externí odkaz:
https://doaj.org/article/a9a3bd487d6a49dbb67d4a79f704b03b
Autor:
Archibold Mposhi, Fabian Cortés-Mancera, Janette Heegsma, Vincent E. de Meijer, Bart van de Sluis, Svenja Sydor, Lars P. Bechmann, Claudia Theys, Peter de Rijk, Tim De Pooter, Wim Vanden Berghe, İkbal Agah İnce, Klaas Nico Faber, Marianne G. Rots
Publikováno v:
Frontiers in Nutrition, Vol 10 (2023)
IntroductionHepatic lipid accumulation and mitochondrial dysfunction are hallmarks of metabolic associated fatty liver disease (MAFLD), yet molecular parameters underlying MAFLD progression are not well understood. Differential methylation within the
Externí odkaz:
https://doaj.org/article/1824ad711d384cc69785ea814dba5292
Autor:
Claudia Theys, Joe Ibrahim, Ligia Mateiu, Archibold Mposhi, Laura García-Pupo, Tim De Pooter, Peter De Rijk, Mojca Strazisar, İkbal Agah İnce, Iuliana Vintea, Marianne G. Rots, Wim Vanden Berghe
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 22, p 16412 (2023)
Metabolic dysfunction-associated steatotic liver disease (MASLD) is characterized by a constant accumulation of lipids in the liver. This hepatic lipotoxicity is associated with a dysregulation of the first step in lipid catabolism, known as beta oxi
Externí odkaz:
https://doaj.org/article/d89f86332a2e4178b0e6dfb6fc1cdb9c
Autor:
Arne De Roeck, Wouter De Coster, Liene Bossaerts, Rita Cacace, Tim De Pooter, Jasper Van Dongen, Svenn D’Hert, Peter De Rijk, Mojca Strazisar, Christine Van Broeckhoven, Kristel Sleegers
Publikováno v:
Genome Biology, Vol 20, Iss 1, Pp 1-16 (2019)
Abstract Technological limitations have hindered the large-scale genetic investigation of tandem repeats in disease. We show that long-read sequencing with a single Oxford Nanopore Technologies PromethION flow cell per individual achieves 30× human
Externí odkaz:
https://doaj.org/article/1d02fd4ea8c841ecbdd6acbde58630b6
Autor:
Giulia Ascari, Nanna D. Rendtorff, Marieke De Bruyne, Julie De Zaeytijd, Michel Van Lint, Miriam Bauwens, Mattias Van Heetvelde, Gavin Arno, Julie Jacob, David Creytens, Jo Van Dorpe, Thalia Van Laethem, Toon Rosseel, Tim De Pooter, Peter De Rijk, Wouter De Coster, Björn Menten, Alfredo Dueñas Rey, Mojca Strazisar, Mette Bertelsen, Lisbeth Tranebjaerg, Elfride De Baere
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Inactivating variants as well as a missense variant in the centrosomal CEP78 gene have been identified in autosomal recessive cone-rod dystrophy with hearing loss (CRDHL), a rare syndromic inherited retinal disease distinct from Usher syndrome. Apart
Externí odkaz:
https://doaj.org/article/483ae383a34a48e1a6bbe9032362f8b3
Autor:
Biljana Ermanoska, William W. Motley, Ricardo Leitão-Gonçalves, Bob Asselbergh, LaTasha H. Lee, Peter De Rijk, Kristel Sleegers, Tinne Ooms, Tanja A. Godenschwege, Vincent Timmerman, Kenneth H. Fischbeck, Albena Jordanova
Publikováno v:
Neurobiology of Disease, Vol 68, Iss , Pp 180-189 (2014)
Aminoacyl-tRNA synthetases are ubiquitously expressed proteins that charge tRNAs with their cognate amino acids. By ensuring the fidelity of protein synthesis, these enzymes are essential for the viability of every cell. Yet, mutations in six tRNA sy
Externí odkaz:
https://doaj.org/article/1c8ff5a5c8544ffba3587694d672656c
Autor:
Karen Verstraete, Els Van Coillie, Hadewig Werbrouck, Stephanie Van Weyenberg, Lieve Herman, Jurgen Del-Favero, Peter De Rijk, Lieven De Zutter, Maria-Adelheid Joris, Marc Heyndrickx, Koen DeReu
Publikováno v:
Toxins, Vol 6, Iss 4, Pp 1201-1221 (2014)
Shiga toxin-producing E. coli (STEC), of various serogroups harboring the intimin gene, form a serious threat to human health. They are asymptomatically carried by cattle. In this study, a quantitative real-time PCR (qPCR) method was developed as a m
Externí odkaz:
https://doaj.org/article/1c29d1678313439ba1ced749d53094bb
Autor:
Kris Laukens, Geert Joris, Wim Vanden Berghe, Peter De Rijk, Mojca Strazisar, Louis Maes, Joris Van Meenen, Bart Cuypers, Emilie Logie
Ferroptosis is a lipid peroxidation-dependent mechanism of regulated cell death known to suppress tumor proliferation and progression. Although several genetic and protein hallmarks have been identified in ferroptotic cell death, it remains challengi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6cbcbadf0bda76886e6eb6e08fdc2b0b
https://doi.org/10.1101/2021.10.13.461056
https://doi.org/10.1101/2021.10.13.461056
Autor:
Sophia Cammaerts, Mojca Strazisar, Bart Smets, Sarah Weckhuysen, Annelie Nordin, Peter De Jonghe, Rolf Adolfsson, Peter De Rijk, Jurgen Del Favero
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0144428 (2015)
As regulators of gene expression, microRNAs (miRNAs) are likely to play an important role in the development of disease. In this study we present a large-scale strategy to identify miRNAs with a role in the regulation of neuronal processes. Thereby w
Externí odkaz:
https://doaj.org/article/5421c2f777ad41dfa992b9c6bea8db3d
Autor:
Alexander, Neumann, Fahri, Küçükali, Isabelle, Bos, Stephanie J B, Vos, Sebastiaan, Engelborghs, Tim, De Pooter, Geert, Joris, Peter, De Rijk, Ellen, De Roeck, Magda, Tsolaki, Frans, Verhey, Pablo, Martinez-Lage, Mikel, Tainta, Giovanni, Frisoni, Oliver, Blin, Jill, Richardson, Régis, Bordet, Philip, Scheltens, Julius, Popp, Gwendoline, Peyratout, Peter, Johannsen, Lutz, Frölich, Rik, Vandenberghe, Yvonne, Freund-Levi, Johannes, Streffer, Simon, Lovestone, Cristina, Legido-Quigley, Mara, Ten Kate, Frederik, Barkhof, Mojca, Strazisar, Henrik, Zetterberg, Lars, Bertram, Pieter Jelle, Visser, Christine, van Broeckhoven, Kristel, Sleegers
Publikováno v:
Molecular psychiatry. 27(4)
Alzheimer's disease (AD) biomarkers represent several neurodegenerative processes, such as synaptic dysfunction, neuronal inflammation and injury, as well as amyloid pathology. We performed an exome-wide rare variant analysis of six AD biomarkers (β
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bee78aac0b6859414f0159ed240be4ed
https://pubmed.ncbi.nlm.nih.gov/35173266
https://pubmed.ncbi.nlm.nih.gov/35173266