Zobrazeno 1 - 10
of 406
pro vyhledávání: '"Peter, Canoll"'
Autor:
Hairong Wang, Michael G. Argenziano, Hyunsoo Yoon, Deborah Boyett, Akshay Save, Petros Petridis, William Savage, Pamela Jackson, Andrea Hawkins-Daarud, Nhan Tran, Leland Hu, Kyle W. Singleton, Lisa Paulson, Osama Al Dalahmah, Jeffrey N. Bruce, Jack Grinband, Kristin R. Swanson, Peter Canoll, Jing Li
Publikováno v:
npj Digital Medicine, Vol 7, Iss 1, Pp 1-14 (2024)
Abstract Intratumoral heterogeneity poses a significant challenge to the diagnosis and treatment of recurrent glioblastoma. This study addresses the need for non-invasive approaches to map heterogeneous landscape of histopathological alterations thro
Externí odkaz:
https://doaj.org/article/d5dad2992549480bb73b3faa28c1de97
Autor:
Xu Hua, Hui Zhou, Hui-Chen Wu, Julia Furnari, Corina P. Kotidis, Raul Rabadan, Jeanine M. Genkinger, Jeffrey N. Bruce, Peter Canoll, Regina M. Santella, Zhiguo Zhang
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Aberrant DNA methylation patterns have been used for cancer detection. However, DNA hemi-methylation, present at about 10% CpG dinucleotides, has been less well studied. Here we show that a majority of differentially hemi-methylated regions
Externí odkaz:
https://doaj.org/article/50798e554b5e4411b46deb180e2635df
Autor:
Dennis Huang, Angeliki Mela, Natarajan V. Bhanu, Benjamin A. Garcia, Peter Canoll, Patrizia Casaccia
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 57, Iss , Pp 101042- (2024)
Proneural gliomas are brain tumors characterized by enrichment of oligodendrocyte progenitor cell (OPC) transcripts and genetic alterations. In this study we sought to identify transcriptional and epigenetic differences between OPCs with Trp53 deleti
Externí odkaz:
https://doaj.org/article/6db1d6b7c3b943999a65b9f97ac8f027
Autor:
Natanael Zarco, Athanassios Dovas, Virginea de Araujo Farias, Naveen K.H. Nagaiah, Ashley Haddock, Peter A. Sims, Dolores Hambardzumyan, Christian T. Meyer, Peter Canoll, Steven S. Rosenfeld, Rajappa S. Kenchappa
Publikováno v:
iScience, Vol 27, Iss 12, Pp 111311- (2024)
Summary: While mitotic spindle inhibitors specifically kill proliferating tumor cells without the toxicities of microtubule poisons, resistance has limited their clinical utility. Treating glioblastomas with the spindle inhibitors ispinesib, aliserti
Externí odkaz:
https://doaj.org/article/fff89d0ebc074d0d9a058fe324ae3cb5
Publikováno v:
Pharmaceuticals, Vol 17, Iss 8, p 973 (2024)
Glioblastoma remains a devastating disease with a bleak prognosis despite continued research and numerous clinical trials. Convection-enhanced delivery offers researchers and clinicians a platform to bypass the blood–brain barrier and administer dr
Externí odkaz:
https://doaj.org/article/b94e5f7c13ac4ce7a69df87e089fbd3b
Publikováno v:
Frontiers in Aging Neuroscience, Vol 16 (2024)
Alzheimer’s disease (AD) is the most frequent form of dementia. It is characterized by pronounced neuronal degeneration with formation of neurofibrillary tangles and deposition of amyloid β throughout the central nervous system. Animal models have
Externí odkaz:
https://doaj.org/article/916d114859f74b4a88719425c2630917
Autor:
Osama Al-Dalahmah, Michael G. Argenziano, Adithya Kannan, Aayushi Mahajan, Julia Furnari, Fahad Paryani, Deborah Boyett, Akshay Save, Nelson Humala, Fatima Khan, Juncheng Li, Hong Lu, Yu Sun, John F. Tuddenham, Alexander R. Goldberg, Athanassios Dovas, Matei A. Banu, Tejaswi Sudhakar, Erin Bush, Andrew B. Lassman, Guy M. McKhann, Brian J. A. Gill, Brett Youngerman, Michael B. Sisti, Jeffrey N. Bruce, Peter A. Sims, Vilas Menon, Peter Canoll
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Glioblastoma (GBM) diffusely infiltrates the brain and intermingles with non-neoplastic brain cells, including astrocytes, neurons and microglia/myeloid cells. This complex mixture of cell types forms the biological context for therapeutic r
Externí odkaz:
https://doaj.org/article/84706af8be0f4cffa61c89d018e75e54
Autor:
Pavan S. Upadhyayula, Dominique M. Higgins, Angeliki Mela, Matei Banu, Athanassios Dovas, Fereshteh Zandkarimi, Purvi Patel, Aayushi Mahajan, Nelson Humala, Trang T. T. Nguyen, Kunal R. Chaudhary, Lillian Liao, Michael Argenziano, Tejaswi Sudhakar, Colin P. Sperring, Benjamin L. Shapiro, Eman R. Ahmed, Connor Kinslow, Ling F. Ye, Markus D. Siegelin, Simon Cheng, Rajesh Soni, Jeffrey N. Bruce, Brent R. Stockwell, Peter Canoll
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Diet intervention is emerging as an option to improve cancer therapy. Here, the authors show that a diet with restrictive cysteine and methionine synergizes with a ferroptosis inducer to increase cell death and survival in glioma preclinical models.
Externí odkaz:
https://doaj.org/article/d887ba793f1142b985b1d97d66d45514
Autor:
Xu Zhang, Zhiguo Zhang, Raul Rabadan, Peter Canoll, Claire Vanpouille-Box, Hanna Minns, Oscar Padilla, Hong-Jian Wei, Robyn D Gartrell, Andrea Webster-Carrion, Masih Tazhibi, Nicholas McQuillan, Matthew Gallitto, Rebecca Yeh, Tom Hei, Luca Szalontay, Jovana Pavisic, Guy Garty, James Garvin, Vilas Menon, Marta Olah, Cheng-Chia Wu
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/a99f5d9f84394dd9a7b25cbed6dd61d0
Autor:
Lisa Sprinzen, Franklin Garcia, Angeliki Mela, Liang Lei, Pavan Upadhyayula, Aayushi Mahajan, Nelson Humala, Lisa Manier, Richard Caprioli, Alfredo Quiñones-Hinojosa, Patrizia Casaccia, Peter Canoll
Publikováno v:
Cells, Vol 13, Iss 3, p 219 (2024)
Isocitrate Dehydrogenase-1 (IDH1) is commonly mutated in lower-grade diffuse gliomas. The IDH1R132H mutation is an important diagnostic tool for tumor diagnosis and prognosis; however, its role in glioma development, and its impact on response to the
Externí odkaz:
https://doaj.org/article/29984ddfb1b640858558c0a9d472a605