Zobrazeno 1 - 10
of 123
pro vyhledávání: '"Peter, Århem"'
Autor:
Hans Liljenström, Peter Århem
It was not long ago when the consciousness was not considered a problem for science. However, this has now changed and the problem of consciousness is considered the greatest challenge to science. In the last decade, a great number of books and artic
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 12 (2018)
Understanding the relationships between the rates and dynamics of current wave forms under voltage clamp conditions is essential for understanding phenomena such as state-dependence and use-dependence, which are fundamental for the action of drugs us
Externí odkaz:
https://doaj.org/article/167094c6fa424ab58247d5c90bbafc38
The main aim of this book is to raise and clear up the intriguing problems of noise and chaos in the nervous system. What functional role do fluctuations in neural systems play? Are there chaotic processes in the brain? What is the neural code, and h
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
Scientific Reports
Scientific Reports
Block of voltage-gated potassium (Kv) channels has been demonstrated to affect neuronal activity described as increasing excitability. The effect has been associated with a closed-state dependent block. However, the block of Kv channels in e.g. local
Autor:
Peter Århem, B. Ingemar B. Lindahl
Publikováno v:
Journal of Theoretical and Philosophical Psychology. 39:46-59
This article examines three aspects of the problem of understanding Benjamin Libet's idea of conscious will causally interacting with certain neural activities involved in generating overt bodily m ...
Autor:
Peter Århem
Publikováno v:
Karl Popper's Science and Philosophy ISBN: 9783030670351
This chapter examines the view of Popper on the mind-brain relation in the light of neuroscience. It is based on two interviews that Ingemar Lindahl and I made with him 1992 and 1994. In these interviews Popper presents an extension of his interactio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3e1e0f45fa6228e0bbabf7218a6c84bd
https://doi.org/10.1007/978-3-030-67036-8_15
https://doi.org/10.1007/978-3-030-67036-8_15
Autor:
Richard, Ågren, Hugo, Zeberg, Tomasz Maciej, Stępniewski, R Benjamin, Free, Sean W, Reilly, Robert R, Luedtke, Peter, Århem, Francisco, Ciruela, David R, Sibley, Robert H, Mach, Jana, Selent, Johanna, Nilsson, Kristoffer, Sahlholm
Publikováno v:
ACS Chemical Neuroscience
A solid understanding of the mechanisms governing ligand binding is crucial for rational design of therapeutics targeting the dopamine D2 receptor (D2R). Here, we use G protein-coupled inward rectifier potassium (GIRK) channel activation in Xenopus o
Autor:
Robert H. Mach, Tomasz Maciej Stepniewski, Richard Ågren, Peter Århem, Robert R. Luedtke, Jana Selent, David R. Sibley, Sean W. Reilly, Johanna Nilsson, Francisco Ciruela, Hugo Zeberg, R. Benjamin Free, Kristoffer Sahlholm
Publikováno v:
Dipòsit Digital de la UB
Universidad de Barcelona
Universidad de Barcelona
A solid understanding of the mechanisms governing ligand binding is crucial for rational design of therapeutics targeting the dopamine D2 receptor (D2R). Here, we use G protein-coupled inward rectifier potassium (GIRK) channel activation in Xenopus o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a591746e0f81981164b518b6e0dd292e
http://hdl.handle.net/2445/173716
http://hdl.handle.net/2445/173716
Publikováno v:
International Journal of Neuropsychopharmacology
Background Previous evidence suggests that UNC9994 is a beta-arrestin2-selective agonist at the dopamine D2 receptor, lacking ability both to activate and antagonize G protein-dependent signaling. However, this has only been reported by one laborator
Publikováno v:
Biochemical and Biophysical Research Communications. 496:101-104
The muscarinic M2 receptor (M2R) has been shown to display voltage-sensitive agonist binding, based on G protein-activated inward rectifier potassium channel (GIRK) opening and radioligand binding at different membrane voltages. A conserved aspartate