Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Pete Heinzelman"'
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Machine learning (ML) has transformed protein engineering by constructing models of the underlying sequence-function landscape to accelerate the discovery of new biomolecules. ML-guided protein design requires models, trained on local sequen
Externí odkaz:
https://doaj.org/article/e8bffe7bf25249adbc51981c2451ec5c
Publikováno v:
Journal of Biological Engineering, Vol 13, Iss 1, Pp 1-14 (2019)
Abstract Background The promise of biopharmaceuticals comprising one or more binding domains motivates the development of novel methods for de novo isolation and affinity maturation of virion-binding domains. Identifying avenues for overcoming the ch
Externí odkaz:
https://doaj.org/article/8a285cc7d440451697a7eacd573c5aed
Autor:
Pete Heinzelman, Philip A Romero
Publikováno v:
PLoS ONE, Vol 16, Iss 5, p e0251585 (2021)
Understanding how human ACE2 genetic variants differ in their recognition by SARS-CoV-2 can facilitate the leveraging of ACE2 as an axis for treating and preventing COVID-19. In this work, we experimentally interrogate thousands of ACE2 mutants to id
Externí odkaz:
https://doaj.org/article/cb7b93fff865441cad352a40c395de2e
Publikováno v:
International Journal of Alzheimer's Disease, Vol 2016 (2016)
Diagnostic assays that leverage bloodborne neuron-derived (neuronal) nanoscale extracellular vesicles (nsEVs) as “windows into the brain” can predict incidence of Alzheimer’s Disease (AD) many years prior to onset. Beyond diagnostics, bloodborn
Externí odkaz:
https://doaj.org/article/b6c63f6cf9da4a69929c0f02e66889ca
Autor:
Pete Heinzelman, Philip A. Romero
Publikováno v:
Protein Science. 32
Publikováno v:
Journal of Biological Chemistry. 299:103276
Autor:
Pete Heinzelman, Philip A. Romero
Angiotensin Converting-Enzyme 2 (ACE2) is currently being investigated for its ability to beneficially modulate the Angiotensin receptor (ATR) therapeutic axis to treat multiple human diseases, but its broad substrate scope and diverse physiological
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f315378e958559e6b7c04b35a9a52d28
https://doi.org/10.1101/2022.01.03.474817
https://doi.org/10.1101/2022.01.03.474817
Publikováno v:
Protein Eng Des Sel
Understanding how SARS-CoV-2 interacts with different mammalian angiotensin-converting enzyme II (ACE2) cell entry receptors will help elucidate determinants of intra- and cross-species virus transmission, facilitate development of effective new vacc
Publikováno v:
Journal of Biological Engineering, Vol 13, Iss 1, Pp 1-14 (2019)
Journal of Biological Engineering
Journal of Biological Engineering
Background The promise of biopharmaceuticals comprising one or more binding domains motivates the development of novel methods for de novo isolation and affinity maturation of virion-binding domains. Identifying avenues for overcoming the challenges
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Understanding the relationship between protein sequence and function is necessary to design new and useful proteins with applications in bioenergy, medicine, and agriculture. The mapping from sequence to function is tremendously complex