Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Pete A. Williams"'
Autor:
Alessio Canovai, Pete A. Williams
Publikováno v:
Neural Regeneration Research, Vol 20, Iss 1, Pp 41-53 (2025)
Pyrroloquinoline quinone is a quinone described as a cofactor for many bacterial dehydrogenases and is reported to exert an effect on metabolism in mammalian cells/tissues. Pyrroloquinoline quinone is present in the diet being available in foodstuffs
Externí odkaz:
https://doaj.org/article/8d3f6a9b19014f6da82ca259e018a949
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-17 (2024)
Abstract A compromised capacity to maintain NAD pools is recognized as a key underlying pathophysiological feature of neurodegenerative diseases. NAD acts as a substrate in major cell functions including mitochondrial homeostasis, cell signalling, ax
Externí odkaz:
https://doaj.org/article/c62d4651bc754691a932e223690ee151
Autor:
James R. Tribble, Melissa Jöe, Carmine Varricchio, Amin Otmani, Alessio Canovai, Baninia Habchi, Evangelia Daskalakis, Romanas Chaleckis, Andrea Loreto, Jonathan Gilley, Craig E. Wheelock, Gauti Jóhannesson, Raymond C. B. Wong, Michael P. Coleman, Andrea Brancale, Pete A. Williams
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Maintenance of NAD pools is critical for neuronal survival. The capacity to maintain NAD pools declines in neurodegenerative disease. We identify that low NMNAT2, the critical neuronal NAD producing enzyme, drives retinal susceptibility to n
Externí odkaz:
https://doaj.org/article/752e0ceae3fe4a6387d7e708ced0fe15
Autor:
Anne Rombaut, Danica Jovancevic, Raymond Ching-Bong Wong, Alan Nicol, Rune Brautaset, David I. Finkelstein, Christine T. O. Nguyen, James R. Tribble, Pete A. Williams
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-16 (2024)
Abstract Neurodegenerative diseases have common underlying pathological mechanisms including progressive neuronal dysfunction, axonal and dendritic retraction, and mitochondrial dysfunction resulting in neuronal death. The retina is often affected in
Externí odkaz:
https://doaj.org/article/ce457f07715247b08e1d0a372c5df54f
Autor:
Myungjin Kim, Jun Yong Kim, Won-Kyu Rhim, Gloria Cimaglia, Andrew Want, James E. Morgan, Pete A. Williams, Chun Gwon Park, Dong Keun Han, Seungsoo Rho
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-16 (2024)
Abstract The progressive and irreversible degeneration of retinal ganglion cells (RGCs) and their axons is the major characteristic of glaucoma, a leading cause of irreversible blindness worldwide. Nicotinamide adenine dinucleotide (NAD) is a cofacto
Externí odkaz:
https://doaj.org/article/26e41b9264f445c88f07e8d5e2066399
Autor:
Jonas E. Svensson, Martin Bolin, Daniel Thor, Pete A. Williams, Rune Brautaset, Marcus Carlsson, Peder Sörensson, David Marlevi, Rubens Spin-Neto, Monika Probst, Göran Hagman, Anton Forsberg Morén, Miia Kivipelto, Pontus Plavén-Sigray
Publikováno v:
BMC Neurology, Vol 24, Iss 1, Pp 1-10 (2024)
Abstract Background Rapamycin is an inhibitor of the mechanistic target of rapamycin (mTOR) protein kinase, and preclinical data demonstrate that it is a promising candidate for a general gero- and neuroprotective treatment in humans. Results from mo
Externí odkaz:
https://doaj.org/article/6432726833fc4d12a5cd09fe328089f3
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-12 (2024)
Abstract Leber’s hereditary optic neuropathy (LHON) is driven by mtDNA mutations affecting Complex I presenting as progressive retinal ganglion cell dysfunction usually in the absence of extra-ophthalmic symptoms. There are no long-term neuroprotec
Externí odkaz:
https://doaj.org/article/c38a73fa7f8049deb758ef1af5f2a4a5
Autor:
James R. Tribble, Melissa Jöe, Carmine Varricchio, Amin Otmani, Alessio Canovai, Baninia Habchi, Evangelia Daskalakis, Romanas Chaleckis, Andrea Loreto, Jonathan Gilley, Craig E. Wheelock, Gauti Jóhannesson, Raymond C. B. Wong, Michael P. Coleman, Andrea Brancale, Pete A. Williams
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-2 (2024)
Externí odkaz:
https://doaj.org/article/26dff57e67d64561bc637003537e66aa
Autor:
Alessio Canovai, James R. Tribble, Melissa Jöe, Daniela Y. Westerlund, Rosario Amato, Ian A. Trounce, Massimo Dal Monte, Pete A. Williams
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-23 (2023)
Abstract Retinal ganglion cells are highly metabolically active requiring strictly regulated metabolism and functional mitochondria to keep ATP levels in physiological range. Imbalances in metabolism and mitochondrial mechanisms can be sufficient to
Externí odkaz:
https://doaj.org/article/9b0fb1fc29404f1ebda176ae9e7a591f
Autor:
Christina Herrspiegel, Flavia Plastino, Emma Lardner, Stefan Seregard, Pete A. Williams, Helder André, Gustav Stålhammar
Publikováno v:
BMC Cancer, Vol 23, Iss 1, Pp 1-15 (2023)
Abstract Purpose To develop a prognostic test based on a single blood sample obtained at the time of uveal melanoma diagnosis. Methods 83 patients diagnosed with posterior uveal melanoma between 1996 and 2000 were included. Peripheral serum samples w
Externí odkaz:
https://doaj.org/article/dfb5ef89f6d14bec8ec1dc4e25f047dc