Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Pete, Strong"'
Autor:
Lindsey Cass, Alison Murray, Amanda Davis, Kathy Woodward, Muna Albayaty, Kazuhiro Ito, Pete Strong, John Ayrton, Charlie Brindley, Jayne Prosser, John Murray, Eddie French, Phillip Haywood, Christopher Wallis, Garth Rapeport
Publikováno v:
Pharmacology Research & Perspectives, Vol 9, Iss 1, Pp n/a-n/a (2021)
Abstract PC945 is a novel antifungal triazole formulated for nebulized delivery to treat lung Aspergillus infections. Pharmacokinetic and safety profiles from nonclinical studies and clinical trials in healthy subjects, and subjects with mild asthma
Externí odkaz:
https://doaj.org/article/0bd3a72ad5fc4f21b9cbc8db0aa32460
Autor:
Alison Murray, Lindsey Cass, Kazuhiro Ito, Nicole Pagani, Darius Armstrong-James, Paras Dalal, Anna Reed, Pete Strong
Publikováno v:
Journal of Fungi, Vol 6, Iss 4, p 373 (2020)
Disease due to pulmonary Aspergillus infection remains a significant unmet need, particularly in immunocompromised patients, patients in critical care and those with underlying chronic lung diseases. To date, treatment using inhaled antifungal agents
Externí odkaz:
https://doaj.org/article/561997543a9b4e2f8952141bb890a0d3
Autor:
Matthew Coates, Alison Murray, Kathy Woodward, Vicky Wheeler, Meabh McCurdy, Lindsey Cass, Kazuhiro Ito, Bryan Murray, Amanda Davis, Julie Mori, Elizabeth A. Meals, Garth Rapeport, Charlie Brindley, John P. DeVincenzo, Pete Strong, Leah Daly
Publikováno v:
The Journal of Infectious Diseases. 225:2087-2096
Background PC786 is a nebulized nonnucleoside respiratory syncytial virus (RSV) polymerase inhibitor designed to treat RSV, which replicates in the superficial layer of epithelial cells lining the airways. Methods Fifty-six healthy volunteers inocula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d6525cc6578189ec94d7fed43e5587f
https://doi.org/10.1093/infdis/jiaa716
https://doi.org/10.1093/infdis/jiaa716
Autor:
Garth Rapeport, Jacques F. Meis, Yuki Nishimoto, Thomas Colley, Alexandre Alanio, Stéphane Bretagne, Kazuhiro Ito, Pete Strong, Anuradha Chowdhary, Genki Kimura, Leah Daly, Yasuo Kizawa, Cheshta Sharma, Takahiro Nakaoki
Publikováno v:
Journal of Antimicrobial Chemotherapy
Objectives The growing emergence of azole-resistant Aspergillus fumigatus strains worldwide is a major concern for current systemic antifungal treatment. Here we report antifungal activities of a novel inhaled triazole, PC1244, against a collection o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96b3282e4fc5c706fe37474d652d4c54
http://europepmc.org/articles/PMC6753496
http://europepmc.org/articles/PMC6753496
Autor:
Kazuhiro Ito, Kirstie Anya Lucas, Genki Kimura, Yuki Nishimoto, Yasuo Kizawa, Leah Daly, Pete Strong
Publikováno v:
Journal of Experimental Pathology. 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca5362e90c3cb4a6bf5abea76c8234f4
https://doi.org/10.33696/pathology.2.011
https://doi.org/10.33696/pathology.2.011
Autor:
John Ayrton, Muna Albayaty, Eddie French, Alison Murray, Charlie Brindley, Kathy Woodward, Lindsey Cass, Jayne Prosser, Pete Strong, Haywood Phillip A, Ito Kazuhiro, Christopher Wallis, John Murray, Amanda Davis, Garth Rapeport
Publikováno v:
Pharmacology Research & Perspectives, Vol 9, Iss 1, Pp n/a-n/a (2021)
Pharmacology Research & Perspectives
Pharmacology Research & Perspectives
PC945 is a novel antifungal triazole formulated for nebulized delivery to treat lung Aspergillus infections. Pharmacokinetic and safety profiles from nonclinical studies and clinical trials in healthy subjects, and subjects with mild asthma were char
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d6c303576ebff497c68f011ba5552aa
https://doaj.org/article/0bd3a72ad5fc4f21b9cbc8db0aa32460
https://doaj.org/article/0bd3a72ad5fc4f21b9cbc8db0aa32460
Autor:
Kazuhiro, Ito, Yasuo, Kizawa, Genki, Kimura, Yuki, Nishimoto, Leah, Daly, Ian, Knowles, Mark, Hows, John, Ayrton, Pete, Strong
Publikováno v:
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 163
PC945 is a novel antifungal agent, optimised for inhaled treatment. In this study, the relationship between antifungal effects of PC945 and its exposure in the lungs was investigated in Aspergillus fumigatus intranasally infected, temporarily neutrop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a253171a4c841a18ad8cdcad73747429
https://pubmed.ncbi.nlm.nih.gov/34015430
https://pubmed.ncbi.nlm.nih.gov/34015430
Autor:
Anna Reed, Lindsey Cass, Darius Armstrong-James, Kazuhiro Ito, Alison Murray, Nicole Pagani, Pete Strong, Paras Dalal
Publikováno v:
Journal of Fungi
Journal of Fungi, Vol 6, Iss 373, p 373 (2020)
Journal of Fungi, Vol 6, Iss 373, p 373 (2020)
Disease due to pulmonary Aspergillus infection remains a significant unmet need, particularly in immunocompromised patients, patients in critical care and those with underlying chronic lung diseases. To date, treatment using inhaled antifungal agents
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecd3fecf77031b241d73b339d3bd56f0
https://pubmed.ncbi.nlm.nih.gov/33348852
https://pubmed.ncbi.nlm.nih.gov/33348852
Publikováno v:
Respiratory infections.
Although Candida spp. are frequently detected in fungal cultures of respiratory secretions, their presence is normally assumed to reflect benign colonization. However, there is growing evidence that Candida spp. is involved in pathogenesis of respira
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::66543e460dc66fdfda292aba129f4bc4
https://doi.org/10.1183/13993003.congress-2020.2321
https://doi.org/10.1183/13993003.congress-2020.2321
Autor:
Genki Kimura, Nishimoto Yuki, Leah Daly, Kazuhiro Ito, Kirstie Anya Lucas, Pete Strong, Kizawa Yasuo
Although Candida spp. are frequently detected in fungal cultures of respiratory secretions, their presence is normally assumed to reflect benign colonization. However, there is growing evidence that Candida spp. are involved in the pathogenesis of re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ba5d56c9908ef32c91b1856ddb79b483
https://doi.org/10.1101/2020.07.27.222661
https://doi.org/10.1101/2020.07.27.222661
