Assay interference leading to erroneous pregnancy-associated plasma protein-A results.

Autor: Jones SL; Prenatal Screening Laboratory, King George's Hospital, London, UK., Mills I; Department of Clinical Biochemistry, Birmingham Women's Hospital, Birmingham, UK., Petchey M; Department of Clinical Biochemistry, University Hospital Coventry, Coventry, UK., Williams C; Department of Laboratory Medicine, Royal Bolton Hospital, Bolton, UK.

Publikováno v: Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology [Ultrasound Obstet Gynecol] 2023 Jun; Vol. 61 (6), pp. 776-777.

Biocatalysis in Drug Design: Engineered Reductive Aminases (RedAms) Are Used to Access Chiral Building Blocks with Multiple Stereocenters.

Autor: Casamajo AR; Department of Chemistry, University of Manchester, Manchester Institute of Biotechnology, 131 Princess Street, Manchester M1 7DN, United Kingdom., Yu Y; Department of Chemistry, University of Manchester, Manchester Institute of Biotechnology, 131 Princess Street, Manchester M1 7DN, United Kingdom., Schnepel C; School of Engineering Sciences in Chemistry, Biotechnology and Health, Department of Industrial Biotechnology, KTH Royal Institute of Technology, AlbaNova University Center, 11421 Stockholm, Sweden., Morrill C; Department of Chemistry, University of Manchester, Manchester Institute of Biotechnology, 131 Princess Street, Manchester M1 7DN, United Kingdom., Barker R; Department of Chemistry, University of Manchester, Manchester Institute of Biotechnology, 131 Princess Street, Manchester M1 7DN, United Kingdom., Levy CW; Department of Chemistry, University of Manchester, Manchester Institute of Biotechnology, 131 Princess Street, Manchester M1 7DN, United Kingdom., Finnigan J; Prozomix Ltd, Building 4, West End Ind. Estate, Haltwhistle NE49 9HA, United Kingdom., Spelling V; Early Chemical Development, Pharmaceutical Sciences, Biopharmaceuticals R&D, AstraZeneca, Mölndal, 431 50 Gothenburg, Sweden., Westerlund K; Medicinal Chemistry, Research and Early Development; Cardiovascular, Renal and Metabolism, Biopharmaceuticals R&D, AstraZeneca, Pepparedsleden 1, Mölndal, 431 50 Gothenburg Sweden., Petchey M; Compound Synthesis and Management, Discovery Sciences, Biopharmaceuticals R&D, AstraZeneca, Mölndal, 431 50 Gothenburg, Sweden., Sheppard RJ; Medicinal Chemistry, Research and Early Development; Cardiovascular, Renal and Metabolism, Biopharmaceuticals R&D, AstraZeneca, Pepparedsleden 1, Mölndal, 431 50 Gothenburg Sweden., Lewis RJ; Department of Medicinal Chemistry, Research and Early Development, Respiratory and Immunology (R&I), BioPharmaceuticals R&D, AstraZeneca, 43183 Mölndal, Sweden., Falcioni F; Early Chemical Development, Pharmaceutical Sciences, Biopharmaceuticals R&D, AstraZeneca, CB21 6GP Cambridge, United Kingdom., Hayes MA; Compound Synthesis and Management, Discovery Sciences, Biopharmaceuticals R&D, AstraZeneca, Mölndal, 431 50 Gothenburg, Sweden., Turner NJ; Department of Chemistry, University of Manchester, Manchester Institute of Biotechnology, 131 Princess Street, Manchester M1 7DN, United Kingdom.

Publikováno v: Journal of the American Chemical Society [J Am Chem Soc] 2023 Oct 11; Vol. 145 (40), pp. 22041-22046. Date of Electronic Publication: 2023 Oct 02.

Role of methylated septin 9 as an adjunct diagnostic and prognostic biomarker in hepatocellular carcinoma.

Autor: Bannaga AS; Department of Gastroenterology and Hepatology, University Hospital, Coventry UK; Warwick Medical School, University of Warwick, Coventry, UK. Electronic address: ayman.bannaga@warwick.ac.uk., Alvarez R; Department of Biomedical Sciences, Cedars-Sinai, Los Angeles CA, USA., Zhou L; Department of Biomedical Sciences, Cedars-Sinai, Los Angeles CA, USA., Petchey M; Department of Pathology, University Hospital, Coventry UK., Noufaily A; Warwick Medical School, University of Warwick, Coventry, UK., Hitchins MP; Department of Biomedical Sciences, Cedars-Sinai, Los Angeles CA, USA., Arasaradnam RP; Department of Gastroenterology and Hepatology, University Hospital, Coventry UK; Warwick Medical School, University of Warwick, Coventry, UK; Faculty of Health & Life Sciences, Coventry University, Coventry, UK; School of Biological Sciences, University of Leicester, Leicester, UK.

Publikováno v: HPB : the official journal of the International Hepato Pancreato Biliary Association [HPB (Oxford)] 2021 Oct; Vol. 23 (10), pp. 1595-1606. Date of Electronic Publication: 2021 Apr 20.

The Broad Aryl Acid Specificity of the Amide Bond Synthetase McbA Suggests Potential for the Biocatalytic Synthesis of Amides.

Autor: Petchey M; Department of Chemistry, University of York, York, YO10 5DD, UK., Cuetos A; Department of Chemistry, University of York, York, YO10 5DD, UK., Rowlinson B; Department of Chemistry, University of York, York, YO10 5DD, UK., Dannevald S; Department of Chemistry, University of York, York, YO10 5DD, UK., Frese A; Department of Chemistry, University of York, York, YO10 5DD, UK., Sutton PW; GSK Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NY, UK.; Current address: Department of Chemical, Biological and Environmental Engineering, Bioprocess Engineering and Applied Biocatalysis Group, Engineering School, Campus de la UAB, 08193 Bellaterra (Cerdanyola del Vallés), Barcelona, Spain., Lovelock S; GSK Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NY, UK.; Current address: School of Chemistry, University of Manchester, Manchester Institute of Biotechnology, 131 Princess Street, Manchester, M1 7DN, UK., Lloyd RC; GSK Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NY, UK., Fairlamb IJS; Department of Chemistry, University of York, York, YO10 5DD, UK., Grogan G; Department of Chemistry, University of York, York, YO10 5DD, UK.

Publikováno v: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2018 Sep 03; Vol. 57 (36), pp. 11584-11588. Date of Electronic Publication: 2018 Aug 07.

Human OX40L–CAR-Tregs target activated antigen-presenting cells and control T cell alloreactivity.

Autor: Rui, Xianliang, Alvarez Calderon, Francesca, Wobma, Holly, Gerdemann, Ulrike, Albanese, Alexandre, Cagnin, Lorenzo, McGuckin, Connor, Michaelis, Katherine A., Naqvi, Kisa, Blazar, Bruce R., Tkachev, Victor, Kean, Leslie S.

Publikováno v: Science Translational Medicine; 10/16/2024, Vol. 16 Issue 769, p1-16, 16p