Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Petar-Bogomil Kanev"'
Autor:
Georgi Danovski, Greta Panova, Bradley Keister, Georgi Georgiev, Aleksandar Atemin, Sonya Uzunova, Rumen Stamatov, Petar-Bogomil Kanev, Radoslav Aleksandrov, Krastan B. Blagoev, Stoyno S. Stoynov
Publikováno v:
iScience, Vol 27, Iss 9, Pp 110826- (2024)
Summary: During DNA repair, ATM-induced H2AX histone phosphorylation and MDC1 recruitment spread megabases beyond the damage site. While loop extrusion has been suggested to drive this spread, the underlying mechanism remains unclear. Herein, we prov
Externí odkaz:
https://doaj.org/article/14a8058a4f0c4a75968a8af700c246cf
Autor:
Petar-Bogomil Kanev, Sylvia Varhoshkova, Irina Georgieva, Maria Lukarska, Dilyana Kirova, Georgi Danovski, Stoyno Stoynov, Radoslav Aleksandrov
Publikováno v:
Cell Reports, Vol 43, Iss 5, Pp 114234- (2024)
Summary: Poly(ADP-ribose) polymerase (PARP) inhibitors (PARPis) not only suppress PARP1 catalytic activity but also prolong its association to damaged chromatin. Here, through live-cell imaging, we quantify the alterations in PARP1 dynamics and activ
Externí odkaz:
https://doaj.org/article/9e46a1e28703485d886e5375514f41e8
Autor:
Aleksandar Atemin, Aneliya Ivanova, Petar-Bogomil Kanev, Sonya Uzunova, Marina Nedelcheva-Veleva, Stoyno Stoynov
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 15, p 8230 (2024)
The measurement of dynamic changes in protein level and localization throughout the cell cycle is of major relevance to studies of cellular processes tightly coordinated with the cycle, such as replication, transcription, DNA repair, and checkpoint c
Externí odkaz:
https://doaj.org/article/14114fdc32b84f8781206016431d0c27
Autor:
Georgi Danovski, Teodora Dyankova-Danovska, Rumen Stamatov, Radoslav Aleksandrov, Petar-Bogomil Kanev, Stoyno Stoynov
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 23, p 16784 (2023)
Elucidating the dynamics of DNA repair proteins is essential to understanding the mechanisms that preserve genomic stability and prevent carcinogenesis. However, the measurement and modeling of protein dynamics at DNA lesions via currently available
Externí odkaz:
https://doaj.org/article/0c56d27aea7747c0ab8b361a1566f0fc