Výsledky vyhledávání - "Petar, Brlek"

Akademický článek

Implementing Whole Genome Sequencing (WGS) in Clinical Practice: Advantages, Challenges, and Future Perspectives

Autor: Petar Brlek, Luka Bulić, Matea Bračić, Petar Projić, Vedrana Škaro, Nidhi Shah, Parth Shah, Dragan Primorac

Publikováno v: Cells, Vol 13, Iss 6, p 504 (2024)

The integration of whole genome sequencing (WGS) into all aspects of modern medicine represents the next step in the evolution of healthcare. Using this technology, scientists and physicians can observe the entire human genome comprehensively, genera

Externí odkaz: https://doaj.org/article/a8285cdfccbd49caadde7557f6b368aa

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Akademický článek

Case report: State-of-the-art risk-modifying treatment of sudden cardiac death in an asymptomatic patient with a mutation in the SCN5A gene and a review of the literature

Autor: Petar Brlek, Eduard Stjepan Pavelić, Jana Mešić, Kristijan Vrdoljak, Andrea Skelin, Šime Manola, Nikola Pavlović, Jasmina Ćatić, Gordana Matijević, Josep Brugada, Dragan Primorac

Publikováno v: Frontiers in Cardiovascular Medicine, Vol 10 (2023)

Brugada syndrome is a rare hereditary disorder characterized by distinct ECG findings, complex genetics, and a high risk of sudden cardiac death. Recognition of the syndrome is crucial as it represents a paradigm of sudden death tragedy in individual

Externí odkaz: https://doaj.org/article/ea25581b808c47029ec73fd3b69dce39

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Akademický článek

Budućnost cjelogenomskog sekvenciranja u pedijatriji

Autor: Petar Brlek, Dragan Primorac

Publikováno v: Liječnički vjesnik, Vol 145, Iss Supp 5, Pp 51-58 (2023)

Sekvenciranje cijeloga genoma (eng. Whole genome sequencing – WGS) postaje sve zastupljeniji genetički dijagnostički test u svakodnevnoj kliničkoj praksi. Inicijativa za medicinski genom (eng. Medical Genome Initiative – MGI), prepoznala je WG

Externí odkaz: https://doaj.org/article/a8e807f42491427c8c9e50a89aa36c1c

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Akademický článek

Novel Approach in Rectovaginal Fistula Treatment: Combination of Modified Martius Flap and Autologous Micro-Fragmented Adipose Tissue

Autor: Ana Dimova, Ivana Erceg Ivkošić, Petar Brlek, Stefan Dimov, Tomislav Pavlović, Tomislav Bokun, Dragan Primorac

Publikováno v: Biomedicines, Vol 11, Iss 9, p 2509 (2023)

In this paper, we introduce an innovative therapeutic approach for managing rectovaginal fistulas (RVF), by combining the modified Martius flap and micro-fragmented adipose tissue (MFAT) enriched with mesenchymal stem cells (MSC). This novel approach

Externí odkaz: https://doaj.org/article/f705c403716e449e88eab2bf7344401d

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Akademický článek

Successful Treatment of a Rare Cholesterol Homeostasis Disorder Due to CYP27A1 Gene Mutation with Chenodeoxycholic Acid Therapy

Autor: Petar Brlek, Luka Bulić, David Glavaš Weinberger, Jelena Bošnjak, Tomislav Pavlović, Svetlana Tomić, Zdravka Krivdić Dupan, Igor Borić, Dragan Primorac

Publikováno v: Biomedicines, Vol 11, Iss 5, p 1430 (2023)

Cerebrotendinous xanthomatosis (CTX) is a genetic disorder of the cholesterol metabolic pathway, most often associated with variants in the CYP27A1 gene. The dysregulation of cholesterol metabolism results in the accumulation of metabolites such as c

Externí odkaz: https://doaj.org/article/bd3056ac8d5241c1ab3f8d20cc3e8c74

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Akademický článek

Importance of Cellular Immunity and IFN-γ Concentration in Preventing SARS-CoV-2 Infection and Reinfection: A Cohort Study

Autor: Dragan Primorac, Petar Brlek, Eduard Stjepan Pavelić, Jana Mešić, David Glavaš Weinberger, Vid Matišić, Vilim Molnar, Saša Srića, Renata Zadro

Publikováno v: Viruses, Vol 15, Iss 3, p 792 (2023)

Recent studies have highlighted the underestimated importance of the cellular immune response after the emergence of variants of concern (VOCs) of SARS-CoV-2, and the significantly reduced neutralizing power of antibody titers in individuals with pre

Externí odkaz: https://doaj.org/article/55d381e3d91848b7aacd05c98e6f540a

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Akademický článek

Adaptive Immune Responses and Immunity to SARS-CoV-2

Autor: Dragan Primorac, Kristijan Vrdoljak, Petar Brlek, Eduard Pavelić, Vilim Molnar, Vid Matišić, Ivana Erceg Ivkošić, Marijo Parčina

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

Since the onset of the COVID-19 pandemic, the medical field has been forced to apply the basic knowledge of immunology with the most up-to-date SARS-CoV-2 findings and translate it to the population of the whole world in record time. Following the in

Externí odkaz: https://doaj.org/article/c862d32ab7404da9895cf5547424e1c5

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Akademický článek

Cellular Immunity—The Key to Long-Term Protection in Individuals Recovered from SARS-CoV-2 and after Vaccination

Autor: Dragan Primorac, Petar Brlek, Vid Matišić, Vilim Molnar, Kristijan Vrdoljak, Renata Zadro, Marijo Parčina

Publikováno v: Vaccines, Vol 10, Iss 3, p 442 (2022)

Previous clinical and epidemiological studies have shown that over time antibody titers decrease, and they do not provide long-term mucosa protection against SARS-CoV-2 infection. Additionally, the increase in breakthrough infections that occur more

Externí odkaz: https://doaj.org/article/c6c84d164af34dbe84610509099f9334

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