Výsledky vyhledávání

Akademický článek

Cholesterol Regulates Syntaxin 6 Trafficking at trans-Golgi Network Endosomal Boundaries

Publikováno v: Cell Reports, Vol 7, Iss 3, Pp 883-897 (2014)

Inhibition of cholesterol export from late endosomes causes cellular cholesterol imbalance, including cholesterol depletion in the trans-Golgi network (TGN). Here, using Chinese hamster ovary (CHO) Niemann-Pick type C1 (NPC1) mutant cell lines and hu

Externí odkaz: https://doaj.org/article/06a91864d03547b39c978ce313decb26

Zobrazit plný text záznamu

Akademický článek

Inhibition of mitogen-activated protein kinase Erk1/2 promotes protein degradation of ATP binding cassette transporters A1 and G1 in CHO and HuH7 cells.

Autor: Vishwaroop Mulay, Peta Wood, Melanie Manetsch, Masoud Darabi, Rose Cairns, Monira Hoque, Karen Cecilia Chan, Meritxell Reverter, Anna Alvarez-Guaita, Kerry-Anne Rye, Carles Rentero, Joerg Heeren, Carlos Enrich, Thomas Grewal

Publikováno v: PLoS ONE, Vol 8, Iss 4, p e62667 (2013)

Signal transduction modulates expression and activity of cholesterol transporters. We recently demonstrated that the Ras/mitogen-activated protein kinase (MAPK) signaling cascade regulates protein stability of Scavenger Receptor BI (SR-BI) through Pr

Externí odkaz: https://doaj.org/article/84c70b55205c40c1ab31fa16bdb9987d

Zobrazit plný text záznamu

Annexin A6 is a scaffold for PKCa to promote EGFR inactivation

Autor: Katia Monastyrskaya, Rose Cairns, Meritxell Reverter, Carlos Enrich, Anna Alvarez-Guaita, Monira Hoque, William E. Hughes, Francesc Tebar, Peta Wood, Thomas Grewal, Alexander Swarbrick, Carles Rentero, S Vilá de Muga, Roger J. Daly, B P Kota, Meryem Koese

Publikováno v: Oncogene

Protein kinase Ca (PKCa) can phosphorylate the epidermal growth factor receptor (EGFR) at threonine 654 (T654) to inhibit EGFR tyrosine phosphorylation (pY EGFR) and the associated activation of downstream effectors. However upregulation of PKCa in a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a87b372142162d751f54c4775985478b

Zobrazit plný text záznamu

Cholesterol transport from late endosomes to the Golgi regulates t-SNARE trafficking, assembly, and function

Autor: Joan Blasi, Vishwaroop Mulay, Carles Rentero, Meritxell Reverter, Rose Cairns, Thomas Grewal, Peta Wood, Katia Monastyrskaya, Anna Alvarez-Guaita, Carlos Enrich, Albert Pol, Francesc Tebar, Sandra Vilà de Muga

Publikováno v: Molecular Biology of the Cell. 22:4108-4123

Cholesterol regulates plasma membrane (PM) association and functioning of syntaxin-4 and soluble N-ethylmaleimide-sensitive fusion protein 23 (SNAP23) in the secretory pathway. However, the molecular mechanism and cellular cholesterol pools that dete

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ce87f32a6701cf855e7246e29c4a29e7
https://doi.org/10.1091/mbc.e11-04-0332r

Zobrazit plný text záznamu

Annexin A6-Induced Alterations in Cholesterol Transport and Caveolin Export from the Golgi Complex

Autor: Albert Pol, Katharina Gaus, Mercedes Ingelmo-Torres, Rachael Evans, Laia Cubells, Sandra Vilà de Muga, Peta Wood, Thomas Grewal, Francesc Tebar, Maria Calvo, Carlos Enrich

Publikováno v: Traffic (Copenhagen, Denmark)

Annexin A6 (AnxA6) belongs to a family of Ca(2+)-dependent membrane-binding proteins and is involved in the regulation of endocytic and exocytic pathways. We previously demonstrated that AnxA6 regulates receptor-mediated endocytosis and lysosomal tar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9f5d05af46854cd22c46e14d923bbbb
http://europepmc.org/articles/PMC3003291

Zobrazit plný text záznamu

Identification of dual PPARα/γ agonists and their effects on lipid metabolism

Autor: Andrew J. Hoy, Vivian Wan Yu Liao, Rose Cairns, Hsuan-Yu Jennifer Lin, David E. Hibbs, Jennifer Ong, Paul W. Groundwater, Thomas Grewal, Helena Sjöström, Quanqing Gao, Linda Váradi, Felcia Lai, Jacky Hanh, Seher Balaban, Peta Wood

Publikováno v: Bioorganicmedicinal chemistry. 23(24)

The three peroxisome proliferator-activated receptor (PPAR) isoforms; PPARα, PPARγ and PPARδ, play central roles in lipid metabolism and glucose homeostasis. Dual PPARα/γ agonists, which stimulate both PPARα and PPARγ isoforms to similar exten

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::664b8298bfe47ed3f1e497fd28e1c11f
https://pubmed.ncbi.nlm.nih.gov/26616289

Zobrazit plný text záznamu

Inhibition of H-Ras and MAPK is compensated by PKC-dependent pathways in annexin A6 expressing cells

Autor: Carlos Enrich, William E. Hughes, Francesc Tebar, Laia Cubells, Iñaki de Diego, Rachael Evans, Peta Wood, Thomas Grewal, Toni E. Hayes, Albert Pol, Sandra Vilà de Muga, Carles Rentero, Kerry-Anne Rye

Publikováno v: Cellular Signalling. 18:1006-1016

High-density lipoprotein (HDL)-induced activation of the Ras/MAPK pathway can be mediated by protein kinase C (PKC)-dependent and independent pathways. Although both pathways co-exist in cells, we showed that binding of HDL to scavenger receptor BI (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb94e487a27c3a18672472a2573ce5fe
https://doi.org/10.1016/j.cellsig.2005.08.008

Zobrazit plný text záznamu

Inhibition of Mitogen-Activated Protein Kinase Erk1/2 Promotes Protein Degradation of ATP Binding Cassette Transporters A1 and G1 in CHO and in HuH7 cells

Autor: Masoud Darabi, Karen Cecilia Chan, Vishwaroop Mulay, Thomas Grewal, Meritxell Reverter, Carles Rentero, Carlos Enrich, Anna Alvarez-Guaita, Monira Hoque, Kerry-Anne Rye, Peta Wood, Rose Cairns, Melanie Manetsch, Joerg Heeren

Publikováno v: Recercat. Dipósit de la Recerca de Catalunya
instname
PLoS ONE, Vol 8, Iss 4, p e62667 (2013)
Dipòsit Digital de la UB
Universidad de Barcelona
PLoS ONE

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::061798c17a6ba3417650825630e3d6f6
http://hdl.handle.net/2445/42447

Zobrazit plný text záznamu

Ras/Mitogen-activated Protein Kinase (MAPK) Signaling Modulates Protein Stability and Cell Surface Expression of Scavenger Receptor SR-BI*

Autor: Carlos Enrich, Albert Pol, Masoud Darabi, Gilles Lambert, Peta Wood, Joerg Heeren, Kerry-Anne Rye, Thomas Grewal, Karen Cecilia Chan, Vishwaroop Mulay

The mitogen-activated protein kinase (MAPK) Erk1/2 has been implicated to modulate the activity of nuclear receptors, including peroxisome proliferator activator receptors (PPARs) and liver X receptor, to alter the ability of cells to export choleste

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa6582c9a20a0b7586535697fc06a764
https://europepmc.org/articles/PMC3123075/

Zobrazit plný text záznamu

Annexin A6-Linking Ca(2+) signaling with cholesterol transport

Autor: Meritxell Reverter, Thomas Grewal, Meryem Koese, Peta Wood, Carlos Enrich, Sandra Vilà de Muga, Vishwaroop Mulay, Carles Rentero

Publikováno v: Biochimica et biophysica acta. 1813(5)

Annexin A6 (AnxA6) belongs to a conserved family of Ca2+-dependent membrane-binding proteins. Like other annexins, the function of AnxA6 is linked to its ability to bind phospholipids in cellular membranes in a dynamic and reversible fashion, in part

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e6ba09cee9faf27e38ff727ff27a33d
https://pubmed.ncbi.nlm.nih.gov/20888375

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání